| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $2,017,169 | -43.5% | 219 | +4 | $9,210 | $8,547,705 | 2 | Warner Bros. | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $911,240 | -31.2% | 241 | - | $3,781 | $8,465,913 | 4 | 20th Century Fox International | false | false |
| 3 | 3 | Brüno | $282,269 | -43.1% | 94 | - | $3,002 | $2,299,270 | 3 | Universal Pictures International (UPI) | false | false |
| 4 | - | Ghosts of Girlfriends Past | $209,893 | - | 50 | - | $4,197 | $384,620 | 1 | RCV Film Distribution | true | false |
| 5 | 5 | The Proposal | $207,385 | -19.7% | 82 | -1 | $2,529 | $3,003,048 | 6 | Walt Disney Pictures | false | false |
| 6 | 6 | The Hangover | $206,762 | -17.5% | 66 | - | $3,132 | $3,792,332 | 7 | Warner Bros. | false | false |
| 7 | 4 | Het geheim van Mega Mindy | $179,028 | -35% | 107 | - | $1,673 | $1,258,969 | 3 | Independent Films | false | false |
| 8 | - | Luke and Lucy: The Texas Rangers | $123,594 | - | 87 | - | $1,420 | $134,321 | 1 | RCV Film Distribution | true | false |
| 9 | 7 | Transformers: Revenge of the Fallen | $95,583 | -46% | 63 | -25 | $1,517 | $3,534,364 | 5 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Drag Me to Hell | $54,574 | -31.1% | 19 | -9 | $2,872 | $624,041 | 4 | RCV Film Distribution | false | false |
| 11 | 8 | Angels & Demons | $54,037 | -34% | 43 | -4 | $1,256 | $7,773,453 | 11 | Sony Pictures Releasing | false | false |
| 12 | 10 | Coco Before Chanel | $26,549 | -25.1% | 26 | -3 | $1,021 | $900,714 | 9 | RCV Film Distribution | false | false |
| 13 | - | Ponyo | $17,885 | - | 42 | - | $425 | $19,390 | 1 | Wild Bunch Distribution | true | false |
| 14 | 16 | Disgrace | $13,029 | -9.6% | 9 | - | $1,447 | $249,981 | 8 | A-Film Distribution | false | false |
| 15 | 11 | A Summer in Genoa | $12,949 | -33.9% | 7 | - | $1,849 | $80,505 | 3 | A-Film Distribution | false | false |
| 16 | - | The Escapist | $12,528 | - | 3 | - | $4,176 | $24,893 | 1 | Cinéart | true | false |
| 17 | 13 | 35 Shots of Rum | $12,004 | -23.9% | 6 | - | $2,000 | $48,868 | 2 | Cinéart | false | false |
| 18 | 17 | The Reader | $10,963 | -23.4% | 16 | -2 | $685 | $2,000,700 | 17 | Benelux Film Distributors | false | false |
| 19 | 12 | In the Electric Mist | $10,442 | -42.4% | 11 | - | $949 | $40,137 | 2 | Benelux Film Distributors | false | false |
| 20 | 15 | State of Play | $10,009 | -33.8% | 6 | -2 | $1,668 | $381,660 | 6 | Universal Pictures International (UPI) | false | false |
| 21 | - | Terminator Salvation | $2,232 | - | 3 | - | $744 | $2,114,310 | 8 | Sony Pictures Releasing | false | false |
