| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $2,653,327 | -60.2% | 1,009 | - | $2,629 | $16,400,281 | 2 | Warner Bros. | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $2,129,112 | -38.7% | 467 | -176 | $4,559 | $35,086,217 | 4 | 20th Century Fox International | false | false |
| 3 | - | The Uninvited | $458,190 | - | 249 | - | $1,840 | $464,251 | 1 | Paramount Pictures International | true | false |
| 4 | 3 | Transformers: Revenge of the Fallen | $342,697 | -38.4% | 375 | -72 | $913 | $18,290,978 | 5 | Paramount Pictures International | false | false |
| 5 | 4 | Public Enemies | $314,617 | -36.5% | 274 | -91 | $1,148 | $4,678,174 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | - | Crossing Over | $275,080 | - | 192 | - | $1,432 | $275,080 | 1 | N/A | true | false |
| 7 | - | G-Force | $254,690 | - | 160 | - | $1,591 | $254,690 | - | Walt Disney Pictures | - | false |
| 8 | 7 | My Sister's Keeper | $196,277 | +21.6% | 131 | +6 | $1,498 | $2,095,405 | 5 | Warner Bros. | false | false |
| 9 | 6 | All Inclusive | $119,168 | -36% | 138 | -89 | $863 | $1,208,028 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 5 | The Proposal | $118,287 | -43.1% | 100 | -99 | $1,182 | $6,398,515 | 6 | Walt Disney Pictures | false | false |
| 11 | - | How to Lose Friends & Alienate People | $91,531 | - | 99 | - | $924 | $91,531 | 1 | N/A | true | false |
| 12 | 8 | The Code | $85,948 | -22.7% | 89 | -78 | $965 | $723,204 | 3 | Gussi Films | false | false |
| 13 | 10 | 17 Again | $62,191 | +37% | 75 | -8 | $829 | $2,469,930 | 6 | Gussi Films | false | false |
| 14 | 13 | Smother | $22,690 | +10.7% | 23 | -34 | $986 | $190,928 | 3 | Videocine | false | false |
| 15 | - | Reprise | $17,225 | - | 12 | - | $1,435 | $17,225 | 1 | N/A | true | false |
| 16 | 11 | Up | $13,431 | -68.6% | 34 | -64 | $395 | $14,154,057 | 8 | Walt Disney Pictures | false | false |
| 17 | 28 | Personal Effects | $11,465 | +723.6% | 18 | +14 | $636 | $106,897 | 9 | Gussi Films | false | false |
| 18 | 12 | Night at the Museum: Battle of the Smithsonian | $9,439 | -77.1% | 27 | -64 | $349 | $10,060,637 | 7 | 20th Century Fox International | false | false |
| 19 | 9 | It's Alive | $9,437 | -81.2% | 34 | -26 | $277 | $124,644 | 2 | Gussi Films | false | false |
| 20 | 18 | State of Play | $9,407 | +30.8% | 20 | +5 | $470 | $1,620,557 | 8 | Universal Pictures International (UPI) | false | false |
| 21 | 14 | Gomorrah | $8,764 | -49.3% | 8 | -1 | $1,095 | $70,984 | 3 | N/A | false | false |
| 22 | 17 | Happy-Go-Lucky | $7,928 | -14.9% | 9 | - | $880 | $104,655 | 5 | N/A | false | false |
| 23 | 15 | Waltz with Bashir | $7,627 | -38.6% | 10 | - | $762 | $31,118 | 2 | N/A | false | false |
| 24 | 21 | Three Monkeys | $4,258 | +54.1% | 4 | +3 | $1,064 | $43,366 | 7 | N/A | false | false |
| 25 | 26 | I'm Gonna Explode | $2,212 | +18.4% | 17 | -2 | $130 | $56,566 | 115 | Videocine | false | false |
| 26 | 23 | Blame it on Fidel | $2,033 | -13.6% | 5 | - | $406 | $40,648 | 5 | N/A | false | false |
| 27 | 19 | Angels & Demons | $1,872 | -55.3% | 4 | -10 | $468 | $13,379,208 | 11 | Sony Pictures Releasing | false | false |
| 28 | 29 | The Band's Visit | $1,385 | +82.2% | 5 | +2 | $277 | $64,526 | 8 | N/A | false | false |
| 29 | 22 | Religulous | $1,322 | -51.6% | 2 | -3 | $661 | $30,038 | 3 | N/A | false | false |
| 30 | 24 | Rachel Getting Married | $716 | -63.4% | 2 | -3 | $358 | $156,370 | 19 | Sony Pictures Releasing | false | false |
| 31 | 30 | Star Trek | $80 | -76.2% | 2 | -3 | $40 | $3,415,764 | 12 | Paramount Pictures International | false | false |
