| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $2,249,226 | -66.9% | 870 | -20 | $2,585 | $19,881,085 | 2 | Warner Bros. | false | false |
| 2 | 2 | Transformers: Revenge of the Fallen | $187,183 | -39% | 205 | -80 | $913 | $10,814,210 | 5 | United International Pictures | false | false |
| 3 | 4 | The Hangover | $185,242 | -17.2% | 143 | -19 | $1,295 | $4,200,497 | 6 | Warner Bros. | false | false |
| 4 | 3 | Ghosts of Girlfriends Past | $171,367 | -24.9% | 171 | -24 | $1,002 | $1,857,072 | 4 | Warner Bros. | false | false |
| 5 | 6 | Outlander | $88,668 | -20.4% | 115 | -39 | $771 | $1,299,997 | 4 | Eagle Pictures | false | false |
| 6 | 5 | Coraline | $83,290 | -27.2% | 100 | -32 | $832 | $4,483,864 | 6 | United International Pictures | false | false |
| 7 | 9 | Soul Men | $46,206 | -11.6% | 9 | -1 | $5,134 | $144,362 | 2 | 01 Distribution | false | false |
| 8 | - | Baby Mama | $44,886 | - | 102 | - | $440 | $44,886 | 1 | United International Pictures | true | false |
| 9 | 12 | The Girl with the Dragon Tattoo | $37,226 | +18.7% | 37 | +2 | $1,006 | $4,967,367 | 9 | BIM Distribuzione | false | false |
| 10 | 8 | Un'estate ai Caraibi | $36,755 | -32.2% | 57 | -12 | $644 | $5,077,973 | 7 | Medusa Distribuzione | false | false |
| 11 | 10 | The Boat That Rocked | $33,024 | -5% | 37 | +6 | $892 | $885,014 | 7 | United International Pictures | false | false |
| 12 | 7 | Notorious | $32,175 | -45.8% | 82 | -21 | $392 | $137,876 | 2 | 20th Century Fox International | false | false |
| 13 | 14 | Angels & Demons | $19,544 | -18.1% | 15 | -51 | $1,302 | $26,375,930 | 11 | Sony Pictures Releasing | false | false |
| 14 | 17 | Towelhead | $17,452 | -8.5% | 20 | +1 | $872 | $47,546 | 2 | N/A | false | false |
| 15 | 15 | My Best Friend's Girl | $14,498 | -34.2% | 29 | -14 | $499 | $1,461,672 | 6 | Eagle Pictures | false | false |
| 16 | 16 | Obsessed | $12,495 | -35.7% | 12 | - | $1,041 | $41,589 | 2 | Sony Pictures Releasing | false | false |
| 17 | 11 | Ghost Town | $12,478 | -63.1% | 24 | -26 | $519 | $66,655 | 2 | United International Pictures | false | false |
| 18 | 18 | Gran Torino | $11,217 | -12.4% | 19 | +3 | $590 | $12,763,360 | 20 | Warner Bros. | false | false |
| 19 | - | Jonas Brothers: The 3D Concert Experience | $9,976 | - | 15 | - | $665 | $9,976 | 1 | Walt Disney Pictures | true | false |
| 20 | 34 | Giovanna's Father | $8,997 | +104.4% | 29 | +25 | $310 | $4,846,636 | 46 | Medusa Distribuzione | false | false |
| 21 | 20 | Vincere | $8,696 | -7.8% | 12 | -1 | $724 | $2,882,048 | 10 | 01 Distribution | false | false |
| 22 | 19 | Night at the Museum: Battle of the Smithsonian | $7,842 | -26.7% | 15 | -8 | $522 | $9,729,320 | 10 | 20th Century Fox International | false | false |
| 23 | 31 | Slumdog Millionaire | $6,840 | +44.3% | 14 | +8 | $488 | $8,656,931 | 34 | Lucky Red | false | false |
| 24 | 33 | State of Play | $6,063 | +35.1% | 5 | +3 | $1,212 | $3,440,693 | 13 | United International Pictures | false | false |
| 25 | - | Monsters vs. Aliens | $5,309 | - | 9 | - | $589 | $10,307,309 | 17 | United International Pictures | false | false |
| 26 | 32 | Two Lovers | $5,189 | +15.5% | 5 | +3 | $1,037 | $1,288,036 | 18 | BIM Distribuzione | false | false |
| 27 | - | Adventureland | $5,119 | - | 6 | - | $853 | $15,593 | 3 | Walt Disney Pictures | false | false |
| 28 | 23 | The Friends at the Margherita Cafe | $4,711 | -41.2% | 7 | -22 | $673 | $4,208,029 | 17 | 01 Distribution | false | false |
| 29 | - | Journey to the Center of the Earth | $4,650 | - | 5 | - | $930 | $11,376,686 | 28 | 01 Distribution | false | false |
| 30 | - | The Reader | $4,528 | - | 8 | - | $566 | $3,549,858 | 23 | 01 Distribution | false | false |
| 31 | 26 | Louise hires a contract killer | $4,428 | -26.6% | 4 | -1 | $1,107 | $778,377 | 17 | Fandango | false | false |
| 32 | - | Frozen River | $4,132 | - | 2 | - | $2,066 | $253,490 | 20 | Archibald | false | false |
| 33 | 22 | Crossing Over | $3,767 | -53.3% | 13 | -5 | $289 | $156,371 | 5 | 01 Distribution | false | false |
| 34 | 30 | The Great Alibi | $3,675 | -22.9% | 3 | +1 | $1,225 | $72,513 | 8 | Medusa Distribuzione | false | false |
| 35 | - | Love and Other Crimes | $3,646 | - | 6 | - | $607 | $114,745 | 6 | N/A | false | false |
