| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ice Age: Dawn of the Dinosaurs | $750,071 | - | 100 | - | $7,500 | $12,540,974 | 5 | 20th Century Fox International | false | false |
| 2 | - | Harry Potter and the Half-Blood Prince | $516,431 | - | 112 | - | $4,610 | $5,079,766 | 3 | Warner Bros. | false | false |
| 3 | - | The Proposal | $447,808 | - | 55 | - | $8,141 | $543,716 | 1 | Walt Disney Pictures | true | false |
| 4 | - | The Hangover | $429,730 | - | 48 | - | $8,952 | $1,673,000 | 6 | Warner Bros. | false | false |
| 5 | - | Up | $355,661 | - | 31 | - | $11,472 | $399,150 | 1 | Walt Disney Pictures | true | false |
| 6 | - | Public Enemies | $261,315 | - | 48 | - | $5,444 | $613,688 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | - | Brüno | $123,575 | - | 59 | - | $2,094 | $2,167,745 | 2 | N/A | false | false |
| 8 | - | The Taking of Pelham 123 | $85,111 | - | 14 | - | $6,079 | $112,003 | 1 | Sony Pictures Releasing | true | false |
| 9 | - | Everyone Else | $19,285 | - | 9 | - | $2,142 | $216,361 | 5 | N/A | false | false |
| 10 | - | Crossing Over | $14,364 | - | 1 | - | $14,364 | $173,844 | 9 | N/A | false | false |
| 11 | - | Friends Forever | $14,246 | - | 10 | - | $1,424 | $24,694 | 2 | N/A | false | false |
| 12 | - | Angels & Demons | $6,372 | - | 1 | - | $6,372 | $1,251,218 | 12 | Sony Pictures Releasing | false | false |
| 13 | - | Transformers: Revenge of the Fallen | $3,781 | - | 4 | - | $945 | $1,956,597 | 6 | Universal Pictures International (UPI) | false | false |
| 14 | - | Hannah Montana: The Movie | $2,780 | - | 4 | - | $695 | $1,039,358 | 6 | Walt Disney Pictures | false | false |
| 15 | - | State of Play | $2,769 | - | 2 | - | $1,384 | $1,119,060 | 7 | Universal Pictures International (UPI) | false | false |
