| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $6,795,959 | - | 890 | - | $7,635 | $13,058,743 | 1 | Warner Bros. | true | false |
| 2 | 1 | Transformers: Revenge of the Fallen | $306,754 | -55% | 285 | -210 | $1,076 | $10,331,209 | 4 | United International Pictures | false | false |
| 3 | 2 | Ghosts of Girlfriends Past | $228,204 | -36.8% | 195 | -20 | $1,170 | $1,525,961 | 3 | Warner Bros. | false | false |
| 4 | 3 | The Hangover | $223,657 | -31.2% | 162 | -64 | $1,380 | $3,832,924 | 5 | Warner Bros. | false | false |
| 5 | 5 | Coraline | $114,401 | -55.8% | 132 | -58 | $866 | $4,273,571 | 5 | United International Pictures | false | false |
| 6 | 4 | Outlander | $111,443 | -57.1% | 154 | -42 | $723 | $1,126,009 | 3 | Eagle Pictures | false | false |
| 7 | - | Notorious | $59,328 | - | 103 | - | $576 | $59,328 | 1 | 20th Century Fox International | true | false |
| 8 | 6 | Un'estate ai Caraibi | $54,204 | -60.5% | 69 | -102 | $785 | $4,971,253 | 6 | Medusa Distribuzione | false | false |
| 9 | - | Soul Men | $52,247 | - | 10 | - | $5,224 | $52,247 | 1 | 01 Distribution | true | false |
| 10 | 11 | The Boat That Rocked | $34,777 | -38.6% | 31 | -16 | $1,121 | $817,870 | 6 | United International Pictures | false | false |
| 11 | - | Ghost Town | $33,857 | - | 50 | - | $677 | $33,857 | 1 | United International Pictures | true | false |
| 12 | 10 | The Girl with the Dragon Tattoo | $31,360 | -44.9% | 35 | -22 | $896 | $4,867,739 | 8 | BIM Distribuzione | false | false |
| 13 | 13 | Under the Same Moon | $29,796 | -37% | 10 | - | $2,979 | $194,383 | 3 | 01 Distribution | false | false |
| 14 | 8 | Angels & Demons | $23,877 | -66.3% | 66 | -31 | $361 | $26,157,088 | 10 | Sony Pictures Releasing | false | false |
| 15 | 7 | My Best Friend's Girl | $22,044 | -70.8% | 43 | -64 | $512 | $1,422,014 | 5 | Eagle Pictures | false | false |
| 16 | - | Obsessed | $19,433 | - | 12 | - | $1,619 | $19,433 | 1 | Sony Pictures Releasing | true | false |
| 17 | - | Towelhead | $19,067 | - | 19 | - | $1,003 | $19,067 | 1 | N/A | true | false |
| 18 | 18 | Gran Torino | $12,798 | -0.2% | 16 | - | $799 | $12,650,805 | 19 | Warner Bros. | false | false |
| 19 | 12 | Night at the Museum: Battle of the Smithsonian | $10,699 | -78.3% | 23 | -49 | $465 | $9,679,897 | 9 | 20th Century Fox International | false | false |
| 20 | 16 | Vincere | $9,436 | -50.1% | 13 | -14 | $725 | $2,856,039 | 9 | 01 Distribution | false | false |
| 21 | 21 | My Bloody Valentine | $8,662 | -22.1% | 7 | -1 | $1,237 | $8,518,427 | 11 | Medusa Distribuzione | false | false |
| 22 | 17 | Crossing Over | $8,068 | -49.4% | 18 | -10 | $448 | $148,124 | 4 | 01 Distribution | false | false |
| 23 | - | The Friends at the Margherita Cafe | $8,015 | - | 29 | - | $276 | $4,197,192 | 16 | 01 Distribution | false | false |
| 24 | 9 | St. Trinian's | $7,621 | -88.8% | 35 | -106 | $217 | $111,166 | 2 | Warner Bros. | false | false |
| 25 | 22 | O'Horten | $7,052 | -26.1% | 7 | -4 | $1,007 | $106,699 | 5 | N/A | false | false |
| 26 | 27 | Louise hires a contract killer | $6,030 | -22.4% | 5 | -1 | $1,206 | $769,549 | 16 | Fandango | false | false |
| 27 | 20 | Coco Before Chanel | $5,883 | -48.3% | 15 | -3 | $392 | $1,707,175 | 8 | Warner Bros. | false | false |
| 28 | - | Harry Potter and the Chamber of Secrets | $5,241 | - | 1 | - | $5,241 | $29,583,661 | 346 | Warner Bros. | false | false |
| 29 | - | Mid-August Lunch | $4,941 | - | 1 | - | $4,941 | $3,008,972 | 46 | Fandango | false | false |
| 30 | 32 | The Great Alibi | $4,769 | -5.2% | 2 | +1 | $2,384 | $68,280 | 7 | Medusa Distribuzione | false | false |
| 31 | 31 | Slumdog Millionaire | $4,740 | -5.8% | 6 | -4 | $790 | $8,640,480 | 33 | Lucky Red | false | false |
| 32 | - | Two Lovers | $4,491 | - | 2 | - | $2,245 | $1,278,518 | 17 | BIM Distribuzione | false | false |
| 33 | 25 | State of Play | $4,489 | -51.3% | 2 | -5 | $2,244 | $3,431,026 | 12 | United International Pictures | false | false |
| 34 | - | Giovanna's Father | $4,402 | - | 4 | - | $1,100 | $4,812,362 | 45 | Medusa Distribuzione | false | false |
| 35 | 15 | Terminator Salvation | $1,614 | -91.5% | 16 | -24 | $100 | $4,952,079 | 7 | Sony Pictures Releasing | false | false |
