| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $32,308,774 | - | 584 | - | $55,323 | $32,308,774 | 1 | Warner Bros. | true | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $4,654,018 | -39.6% | 503 | -19 | $9,252 | $33,122,431 | 3 | 20th Century Fox International | false | false |
| 3 | 1 | Brüno | $3,758,238 | -53.6% | 457 | +1 | $8,223 | $16,913,786 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | The Hangover | $1,439,512 | - | 359 | - | $4,009 | $29,626,015 | - | Warner Bros. | - | false |
| 5 | 3 | Transformers: Revenge of the Fallen | $1,108,387 | -52.8% | 405 | -64 | $2,736 | $40,694,314 | 5 | Paramount Pictures International | false | false |
| 6 | 5 | Public Enemies | $768,573 | -54.8% | 360 | -95 | $2,134 | $9,354,492 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | My Sister's Keeper | $618,384 | -43.6% | 311 | -40 | $1,988 | $8,092,397 | 4 | Entertainment Film Distributors | false | false |
| 8 | - | Moon | $257,797 | - | 57 | - | $4,522 | $257,797 | 1 | Warner Bros. | true | false |
| 9 | 7 | Year One | $86,603 | -78% | 168 | -131 | $515 | $4,533,592 | 5 | Sony Pictures Releasing | false | false |
| 10 | 8 | Night at the Museum: Battle of the Smithsonian | $80,948 | -53.1% | 203 | -80 | $398 | $31,942,376 | 9 | 20th Century Fox International | false | false |
| 11 | 9 | Kambakkht Ishq | $54,870 | -67.7% | 25 | -27 | $2,194 | $1,041,367 | 3 | Eros Worldwide | false | false |
| 12 | - | Burma VJ: Reporting from a Closed Country | $51,475 | - | 6 | - | $8,579 | $51,475 | 1 | Periscoop Film | true | false |
| 13 | 16 | 35 Shots of Rum | $49,841 | +14.2% | 20 | +5 | $2,492 | $127,986 | 2 | New Wave Films | false | false |
| 14 | 12 | The Private Lives of Pippa Lee | $46,635 | -35.4% | 26 | +1 | $1,793 | $176,625 | 2 | Icon Film Distribution | false | false |
| 15 | 10 | Shortkut - The Con Is On | $39,030 | -70.1% | 23 | -11 | $1,696 | $235,031 | 2 | Studio 18 | false | false |
| 16 | 28 | Monsters vs. Aliens | $35,444 | +532.5% | 91 | +62 | $389 | $34,467,072 | 16 | Paramount Pictures International | false | false |
| 17 | - | Frozen River | $30,364 | - | 7 | - | $4,337 | $30,364 | 1 | Axiom Films | true | false |
| 18 | 11 | Terminator Salvation | $29,381 | -73.6% | 47 | -78 | $625 | $23,123,360 | 7 | Sony Pictures Releasing | false | false |
| 19 | 18 | New York | $26,272 | -23.3% | 26 | +13 | $1,010 | $617,403 | 4 | Yash Raj Films | false | false |
| 20 | 15 | Looking for Eric | $20,030 | -54.1% | 18 | -37 | $1,112 | $1,991,672 | 6 | Entertainment Film Distributors | false | false |
| 21 | 14 | Angels & Demons | $19,798 | -56.9% | 8 | -27 | $2,474 | $30,277,496 | 10 | Sony Pictures Releasing | false | false |
| 22 | 13 | Fired Up! | $19,349 | -61.1% | 56 | -26 | $345 | $118,059 | 2 | Sony Pictures Releasing | false | false |
| 23 | 17 | Sunshine Cleaning | $15,473 | -57.2% | 8 | -17 | $1,934 | $597,567 | 4 | N/A | false | false |
| 24 | 19 | Hannah Montana: The Movie | $14,297 | -48.6% | 46 | -30 | $310 | $13,660,532 | 12 | Walt Disney Pictures | false | false |
| 25 | 20 | Star Trek | $11,913 | -55% | 14 | -9 | $850 | $34,586,422 | 11 | Paramount Pictures International | false | false |
| 26 | 21 | Rudo y Cursi | $10,394 | -43.7% | 8 | -3 | $1,299 | $232,239 | 4 | Optimum Releasing | false | false |
| 27 | - | The Informers | $10,041 | - | 4 | - | $2,510 | $10,041 | 1 | N/A | true | false |
| 28 | - | Wide Open Spaces | $9,674 | - | 9 | - | $1,074 | $9,674 | 1 | Element Films | true | false |
| 29 | 25 | Katyn | $8,518 | -27.6% | 6 | -5 | $1,419 | $188,138 | 5 | Artificial Eye | false | false |
| 30 | 24 | Last Chance Harvey | $7,807 | -50.1% | 5 | -17 | $1,561 | $3,288,473 | 7 | Momentum Pictures | false | false |
| 31 | 23 | Drag Me to Hell | $7,291 | -53.4% | 8 | -20 | $911 | $10,354,559 | 8 | Lionsgate | false | false |
| 32 | - | Kisses | $6,534 | - | 6 | - | $1,089 | $226,377 | 35 | Element Films | false | false |
| 33 | 26 | Coraline | $4,710 | -59.2% | 27 | -12 | $174 | $11,907,383 | 11 | Universal Pictures International (UPI) | false | false |
| 34 | 22 | Blood: The Last Vampire | $3,516 | -79.3% | 7 | -21 | $502 | $821,356 | 6 | Warner Bros. | false | false |
| 35 | 30 | Synecdoche, New York | $3,455 | -23.2% | 4 | - | $863 | $852,994 | 10 | Revolver Entertainment | false | false |
| 36 | 27 | Cloud 9 | $2,820 | -51.8% | 3 | -3 | $940 | $14,561 | 2 | Soda Pictures | false | false |
| 37 | 37 | The Last House on the Left | $2,381 | +16.9% | 4 | -5 | $595 | $1,844,970 | 6 | Universal Pictures International (UPI) | false | false |
| 38 | 35 | Shirin | $2,309 | -6.9% | 3 | +2 | $769 | $20,950 | 4 | British Film Institute (BFI) | false | false |
| 39 | 36 | Let the Right One In | $2,152 | +5.6% | 1 | -8 | $2,152 | $1,776,429 | 15 | Momentum Pictures | false | false |
| 40 | 31 | Soul Power | $1,891 | -48.7% | 2 | -4 | $945 | $9,800 | 2 | Eureka Entertainment | false | false |
| 41 | 33 | Sleep Furiously | $1,708 | -40.5% | 6 | +1 | $284 | $118,451 | 8 | New Wave Films | false | false |
| 42 | 43 | A Girl Cut in Two | $1,528 | +7.2% | 3 | -1 | $509 | $118,032 | 9 | Artificial Eye | false | false |
| 43 | 50 | Mishima: A Life in Four Chapters 2009 Re-release | $1,475 | +169.2% | 1 | - | $1,475 | $2,027 | 2 | ICA Films | false | false |
| 44 | 29 | Anything for Her | $1,367 | -72.4% | 3 | -4 | $455 | $439,497 | 7 | - | false | false |
| 45 | 34 | In the Loop | $1,174 | -57.1% | 2 | -1 | $587 | $3,494,085 | 14 | Optimum Releasing | false | false |
| 46 | 47 | The End of the Line | $1,079 | +6% | 4 | - | $269 | $84,065 | 6 | Periscoop Film | false | false |
| 47 | 38 | Gigantic | $998 | -50.3% | 4 | -1 | $249 | $22,934 | 4 | The Works UK Distribution | false | false |
| 48 | 32 | State of Play | $753 | -76.7% | 1 | -3 | $753 | $9,153,197 | 13 | Universal Pictures International (UPI) | false | false |
| 49 | 42 | Telstar: The Joe Meek Story | $746 | -54.3% | 4 | - | $186 | $96,532 | 5 | N/A | false | false |
| 50 | 39 | Sugar | $732 | -61.2% | 3 | - | $244 | $37,110 | 7 | Axiom Films | false | false |
| 51 | 40 | Chéri | $696 | -61.3% | 1 | -5 | $696 | $673,008 | 11 | Warner Bros. | false | false |
| 52 | - | Is Anybody There? | $509 | - | 2 | - | $254 | $754,297 | 12 | Optimum Releasing | false | false |
| 53 | - | New Town Killers | $495 | - | 1 | - | $495 | $10,776 | 6 | N/A | false | false |
| 54 | - | The Young Victoria | $359 | - | 1 | - | $359 | $8,084,565 | 20 | Momentum Pictures | false | false |
