| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Transformers: Revenge of the Fallen | $682,159 | -51.1% | 495 | -70 | $1,378 | $9,553,508 | 3 | United International Pictures | false | false |
| 2 | 2 | Ghosts of Girlfriends Past | $361,005 | -20.8% | 215 | -1 | $1,679 | $1,098,750 | 2 | Warner Bros. | false | false |
| 3 | 4 | The Hangover | $325,157 | -16.5% | 226 | -40 | $1,438 | $3,373,992 | 4 | Warner Bros. | false | false |
| 4 | 3 | Outlander | $259,585 | -36.5% | 196 | -1 | $1,324 | $890,836 | 2 | Eagle Pictures | false | false |
| 5 | 5 | Coraline | $258,678 | -32.3% | 190 | -12 | $1,361 | $3,975,045 | 4 | United International Pictures | false | false |
| 6 | 6 | Un'estate ai Caraibi | $137,120 | -38.2% | 171 | -48 | $801 | $4,809,024 | 5 | Medusa Distribuzione | false | false |
| 7 | 7 | My Best Friend's Girl | $75,536 | -27.3% | 107 | -33 | $705 | $1,353,486 | 4 | Eagle Pictures | false | false |
| 8 | 8 | Angels & Demons | $70,856 | -22.1% | 97 | -1 | $730 | $25,793,888 | 9 | Sony Pictures Releasing | false | false |
| 9 | - | St. Trinian's | $67,882 | - | 141 | - | $481 | $67,882 | 1 | Warner Bros. | true | false |
| 10 | 9 | The Girl with the Dragon Tattoo | $56,951 | -22.2% | 57 | -8 | $999 | $4,748,727 | 7 | BIM Distribuzione | false | false |
| 11 | 11 | The Boat That Rocked | $56,615 | -5.1% | 47 | +1 | $1,204 | $742,356 | 5 | United International Pictures | false | false |
| 12 | 10 | Night at the Museum: Battle of the Smithsonian | $49,322 | -25.1% | 72 | -13 | $685 | $9,540,646 | 8 | 20th Century Fox International | false | false |
| 13 | 12 | Under the Same Moon | $47,317 | +13.4% | 10 | - | $4,731 | $121,624 | 2 | 01 Distribution | false | false |
| 14 | 13 | Anamorph | $35,937 | +3.9% | 8 | -1 | $4,492 | $131,277 | 3 | Eagle Pictures | false | false |
| 15 | 14 | Terminator Salvation | $18,945 | -40.5% | 40 | -26 | $473 | $4,851,553 | 6 | Sony Pictures Releasing | false | false |
| 16 | 15 | Vincere | $18,914 | -30.7% | 27 | -17 | $700 | $2,802,533 | 8 | 01 Distribution | false | false |
| 17 | 16 | Crossing Over | $15,942 | -35.9% | 28 | -1 | $569 | $131,232 | 3 | 01 Distribution | false | false |
| 18 | 24 | Gran Torino | $12,819 | +44.6% | 16 | +4 | $801 | $12,481,786 | 18 | Warner Bros. | false | false |
| 19 | 29 | Questione di cuore | $12,597 | +147.9% | 34 | +18 | $370 | $3,745,914 | 13 | 01 Distribution | false | false |
| 20 | 35 | Coco Before Chanel | $11,385 | +583.4% | 18 | -9 | $632 | $1,670,109 | 7 | Warner Bros. | false | false |
| 21 | 28 | My Bloody Valentine | $11,122 | +70.1% | 8 | +3 | $1,390 | $8,498,622 | 10 | Medusa Distribuzione | false | false |
| 22 | 17 | O'Horten | $9,546 | -22.8% | 11 | - | $867 | $94,260 | 4 | N/A | false | false |
| 23 | 23 | Look Both Ways 2009 Re-release | $9,423 | +4.4% | 12 | - | $785 | $96,022 | 4 | Fandango | false | false |
| 24 | 27 | Brideshead Revisited | $9,358 | +16.8% | 9 | +4 | $1,039 | $51,935 | 3 | Walt Disney Pictures | false | false |
| 25 | 26 | State of Play | $9,215 | +14.4% | 7 | +2 | $1,316 | $3,422,874 | 11 | United International Pictures | false | false |
| 26 | - | Paul Blart: Mall Cop | $7,881 | - | 9 | - | $875 | $25,473 | - | Sony Pictures Releasing | - | false |
| 27 | 30 | Louise hires a contract killer | $7,775 | +66.2% | 6 | +3 | $1,295 | $759,527 | 15 | Fandango | false | false |
| 28 | - | Adventureland | $7,618 | - | 15 | - | $507 | $7,618 | 1 | Walt Disney Pictures | true | false |
| 29 | 20 | The Secret of Moonacre | $7,536 | -31.6% | 20 | -10 | $376 | $817,253 | 5 | N/A | false | false |
| 30 | - | Garage | $6,125 | - | 7 | - | $875 | $63,984 | 6 | N/A | false | false |
| 31 | - | Slumdog Millionaire | $5,032 | - | 10 | - | $503 | $8,631,099 | 32 | Lucky Red | false | false |
| 32 | 31 | The Great Alibi | $5,030 | +10.3% | 1 | -1 | $5,030 | $60,057 | 6 | Medusa Distribuzione | false | false |
| 33 | - | I Love You, Beth Cooper | $4,569 | - | 10 | - | $456 | $4,569 | 1 | 20th Century Fox International | true | false |
| 34 | - | Different from Whom | $4,558 | - | 6 | - | $759 | $4,514,200 | 17 | United International Pictures | false | false |
| 35 | - | L'amour | $4,538 | - | 7 | - | $648 | $115,874 | 6 | N/A | false | false |
