| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Transformers: Revenge of the Fallen | $1,395,103 | -67.7% | 565 | -13 | $2,469 | $8,082,579 | 2 | United International Pictures | false | false |
| 2 | - | Ghosts of Girlfriends Past | $456,008 | - | 216 | - | $2,111 | $456,008 | 1 | Warner Bros. | true | false |
| 3 | - | Outlander | $408,576 | - | 197 | - | $2,073 | $408,576 | 1 | Eagle Pictures | true | false |
| 4 | 3 | The Hangover | $389,312 | -40% | 266 | -23 | $1,463 | $2,806,808 | 3 | Warner Bros. | false | false |
| 5 | 2 | Coraline | $382,295 | -45% | 202 | -2 | $1,892 | $3,476,265 | 3 | United International Pictures | false | false |
| 6 | 4 | Un'estate ai Caraibi | $221,939 | -60.8% | 219 | -106 | $1,013 | $4,575,094 | 4 | Medusa Distribuzione | false | false |
| 7 | 5 | My Best Friend's Girl | $103,923 | -64.4% | 140 | -10 | $742 | $1,222,248 | 3 | Eagle Pictures | false | false |
| 8 | 6 | Angels & Demons | $90,949 | -49.4% | 98 | -41 | $928 | $25,747,865 | 8 | Sony Pictures Releasing | false | false |
| 9 | 9 | The Girl with the Dragon Tattoo | $73,167 | -33% | 65 | -18 | $1,125 | $4,661,528 | 6 | BIM Distribuzione | false | false |
| 10 | 7 | Night at the Museum: Battle of the Smithsonian | $65,864 | -62.7% | 85 | -67 | $774 | $9,481,274 | 7 | 20th Century Fox International | false | false |
| 11 | 10 | The Boat That Rocked | $59,631 | -35.2% | 46 | -12 | $1,296 | $647,915 | 4 | United International Pictures | false | false |
| 12 | - | Under the Same Moon | $41,723 | - | 10 | - | $4,172 | $41,723 | 1 | 01 Distribution | true | false |
| 13 | 25 | Anamorph | $34,585 | +266.7% | 9 | -2 | $3,842 | $48,372 | 2 | Eagle Pictures | false | false |
| 14 | 8 | Terminator Salvation | $31,861 | -76.2% | 66 | -101 | $482 | $4,824,340 | 5 | Sony Pictures Releasing | false | false |
| 15 | 16 | Vincere | $27,298 | -22.8% | 44 | +14 | $620 | $2,775,203 | 7 | 01 Distribution | false | false |
| 16 | 12 | Crossing Over | $24,867 | -56% | 29 | -1 | $857 | $104,852 | 2 | 01 Distribution | false | false |
| 17 | 19 | O'Horten | $12,361 | -21.8% | 11 | -2 | $1,123 | $76,161 | 3 | N/A | false | false |
| 18 | - | Samsara | $11,554 | - | 1 | - | $11,554 | $957,003 | 370 | Fandango | false | false |
| 19 | - | Paul Blart: Mall Cop | $11,339 | - | 14 | - | $809 | $11,339 | - | Sony Pictures Releasing | - | false |
| 20 | 11 | The Secret of Moonacre | $11,011 | -81.5% | 30 | -89 | $367 | $794,402 | 4 | N/A | false | false |
| 21 | 17 | Love and Other Crimes | $10,333 | -53.9% | 15 | -8 | $688 | $97,235 | 3 | N/A | false | false |
| 22 | 22 | Filth and Wisdom | $9,167 | -29.2% | 11 | -4 | $833 | $159,288 | 4 | Sacher Distribuzione | false | false |
| 23 | 21 | Look Both Ways 2009 Re-release | $9,027 | -39.5% | 12 | -5 | $752 | $80,592 | 3 | Fandango | false | false |
| 24 | 20 | Gran Torino | $8,865 | -41.9% | 12 | -2 | $738 | $12,647,373 | 17 | Warner Bros. | false | false |
| 25 | - | The Friends at the Margherita Cafe | $8,822 | - | 7 | - | $1,260 | $4,178,115 | 14 | 01 Distribution | false | false |
| 26 | 24 | State of Play | $8,052 | -20.3% | 5 | -1 | $1,610 | $3,408,918 | 10 | United International Pictures | false | false |
| 27 | 18 | Brideshead Revisited | $8,013 | -56.7% | 5 | -10 | $1,602 | $37,248 | 2 | Walt Disney Pictures | false | false |
| 28 | - | My Bloody Valentine | $6,540 | - | 5 | - | $1,308 | $8,480,660 | 9 | Medusa Distribuzione | false | false |
| 29 | 26 | Questione di cuore | $5,081 | -36.5% | 16 | +5 | $317 | $3,786,829 | 12 | 01 Distribution | false | false |
| 30 | 32 | Louise hires a contract killer | $4,679 | -12.6% | 3 | -1 | $1,559 | $747,137 | 14 | Fandango | false | false |
| 31 | - | The Great Alibi | $4,562 | - | 2 | - | $2,281 | $51,549 | 5 | Medusa Distribuzione | false | false |
| 32 | 29 | Two Lovers | $4,500 | -29.8% | 2 | -3 | $2,250 | $1,268,558 | 15 | BIM Distribuzione | false | false |
| 33 | 23 | Cloud 9 | $4,201 | -58.4% | 6 | -3 | $700 | $145,980 | 6 | Warner Bros. | false | false |
| 34 | 15 | Borderland | $1,926 | -94.9% | 6 | -78 | $321 | $238,952 | 3 | Sony Pictures Releasing | false | false |
| 35 | 14 | Coco Before Chanel | $1,666 | -96.2% | 27 | -26 | $61 | $1,675,546 | 6 | Warner Bros. | false | false |
