| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $774,133 | - | 42 | - | $18,431 | $1,297,480 | 1 | United International Pictures | true | false |
| 2 | 1 | Up | $620,580 | -14.4% | 77 | -3 | $8,059 | $5,115,118 | 4 | Walt Disney Pictures | false | false |
| 3 | 2 | Terminator Salvation | $169,557 | -36.7% | 61 | -18 | $2,779 | $2,329,693 | 4 | Sony Pictures Releasing | false | false |
| 4 | 3 | The Unborn | $163,932 | -19.7% | 37 | -8 | $4,430 | $1,053,168 | 3 | United International Pictures | false | false |
| 5 | 4 | Night at the Museum: Battle of the Smithsonian | $134,553 | -31% | 43 | -15 | $3,129 | $4,065,716 | 6 | 20th Century Fox International | false | false |
| 6 | 5 | Duplicity | $103,533 | -19.2% | 34 | -2 | $3,045 | $357,335 | 2 | United International Pictures | false | false |
| 7 | 6 | Angels & Demons | $75,207 | -34.3% | 32 | -20 | $2,350 | $4,291,182 | 7 | Sony Pictures Releasing | false | false |
| 8 | - | Impy's Island | $48,483 | - | 17 | - | $2,851 | $73,645 | 1 | N/A | true | false |
| 9 | 8 | Knowing | $31,518 | -31.7% | 13 | -7 | $2,424 | $781,575 | 5 | N/A | false | false |
| 10 | 9 | In Bruges | $26,849 | +0.2% | 8 | -2 | $3,356 | $69,721 | 2 | N/A | false | false |
| 11 | - | The Air I Breathe | $24,145 | - | 8 | - | $3,018 | $35,898 | 1 | N/A | true | false |
| 12 | 7 | War | $24,087 | -61.1% | 12 | -8 | $2,007 | $132,874 | 2 | N/A | false | false |
| 13 | 11 | Race to Witch Mountain | $8,036 | -44.2% | 9 | -8 | $892 | $1,829,376 | 9 | Walt Disney Pictures | false | false |
| 14 | 12 | Solstice | $6,547 | -39.5% | 3 | -1 | $2,182 | $238,787 | 6 | N/A | false | false |
| 15 | 10 | Flawless | $4,278 | -77.6% | 4 | -5 | $1,069 | $213,503 | 5 | N/A | false | false |
| 16 | 14 | Traitor | $3,795 | -43.3% | 5 | -1 | $759 | $129,054 | 3 | N/A | false | false |
| 17 | 13 | Swing Vote | $2,390 | -77.8% | 5 | -3 | $478 | $92,837 | 5 | N/A | false | false |
| 18 | 15 | Paris, Je T'aime | $1,821 | -72.2% | 1 | -1 | $1,821 | $135,749 | 7 | N/A | false | false |
