| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $47,215 | - | 10 | - | $4,721 | $98,335 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | The Proposal | $19,207 | -34.5% | 7 | - | $2,743 | $78,570 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | The Hangover | $19,103 | -28.7% | 7 | - | $2,729 | $181,014 | 3 | - | false | false |
| 4 | 4 | Drag Me to Hell | $4,779 | -30.1% | 5 | - | $955 | $60,559 | 3 | ACME | false | false |
| 5 | 3 | Terminator Salvation | $3,540 | -57.7% | 9 | +2 | $393 | $169,053 | 4 | Sony Pictures Releasing | false | false |
| 6 | - | Ultimate Heist | $2,853 | - | 2 | - | $1,426 | $2,853 | 1 | ACME | true | false |
| 7 | 5 | Angels & Demons | $1,883 | -50.9% | 5 | -1 | $376 | $292,315 | 7 | Sony Pictures Releasing | false | false |
| 8 | 11 | State of Play | $1,775 | +80.9% | 1 | - | $1,775 | $3,793 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Night at the Museum: Battle of the Smithsonian | $1,459 | -42.4% | 7 | -1 | $208 | $101,166 | 6 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Monsters vs. Aliens | $1,413 | -39.5% | 5 | -1 | $282 | $223,827 | 13 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Fighting | $1,140 | -39.5% | 4 | -3 | $285 | $77,680 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 6 | New in Town | $1,128 | -57.4% | 5 | - | $225 | $48,515 | 4 | ACME | false | false |
| 13 | 12 | Coraline | $593 | -36.3% | 2 | - | $296 | $49,158 | 8 | Universal Pictures International (UPI) | false | false |
| 14 | 13 | My Bloody Valentine | $502 | -20.6% | 1 | - | $502 | $124,231 | 10 | ACME | false | false |
| 15 | 10 | Ghosts of Girlfriends Past | $490 | -67.1% | 2 | -3 | $245 | $65,958 | 5 | - | false | false |
| 16 | 15 | Jonas Brothers: The 3D Concert Experience | $220 | -13.4% | 2 | - | $110 | $4,566 | 3 | Universal Pictures International (UPI) | false | false |
| 17 | 14 | The Tale of Despereaux | $140 | -72.4% | 3 | -2 | $46 | $283,814 | 27 | Universal Pictures International (UPI) | false | false |
| 18 | 26 | Hotel for Dogs | $88 | +137.8% | 1 | - | $88 | $50,053 | 15 | Universal Pictures International (UPI) | false | false |
| 19 | 20 | 17 Again | $63 | -63.4% | 1 | -1 | $63 | $132,047 | 8 | - | false | false |
| 20 | 29 | Star Trek | $60 | +233.3% | 1 | - | $60 | $24,981 | 8 | Universal Pictures International (UPI) | false | false |
| 21 | 27 | I Love You, Man | $41 | +41.4% | 1 | - | $41 | $37,227 | 10 | Universal Pictures International (UPI) | false | false |
| 22 | 23 | Kung Fu Panda | $34 | -66.3% | 1 | - | $34 | $483,946 | 56 | Universal Pictures International (UPI) | false | false |
| 23 | 22 | Madagascar: Escape 2 Africa | $27 | -79.2% | 1 | - | $27 | $754,461 | 31 | Universal Pictures International (UPI) | false | false |
| 24 | 18 | Observe and Report | $16 | -91.4% | 1 | -2 | $16 | $22,996 | 7 | - | false | false |
| 25 | - | Marley & Me | $15 | - | 1 | - | $15 | $139,599 | 16 | Universal Pictures International (UPI) | false | false |
| 26 | 16 | Bolt | $10 | -95.8% | 1 | -2 | $10 | $329,911 | 18 | Universal Pictures International (UPI) | false | false |
