| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Transformers: Revenge of the Fallen | $7,215,700 | -47.9% | 521 | +8 | $13,849 | $27,232,267 | 2 | Paramount Pictures International | false | false |
| 2 | - | The Hangover | $3,155,241 | - | 425 | - | $7,424 | $18,489,661 | - | Warner Bros. | - | false |
| 3 | - | Year One | $1,615,607 | - | 382 | - | $4,229 | $1,615,607 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | My Sister's Keeper | $1,524,650 | - | 355 | - | $4,294 | $1,524,650 | 1 | Entertainment Film Distributors | true | false |
| 5 | 3 | Night at the Museum: Battle of the Smithsonian | $814,388 | -39.6% | 456 | -25 | $1,785 | $31,390,564 | 6 | 20th Century Fox International | false | false |
| 6 | 4 | Terminator Salvation | $700,879 | -47.1% | 393 | -63 | $1,783 | $22,462,636 | 4 | Sony Pictures Releasing | false | false |
| 7 | - | Blood: The Last Vampire | $383,563 | - | 269 | - | $1,425 | $383,563 | 3 | Warner Bros. | false | false |
| 8 | 5 | Angels & Demons | $274,639 | -52.9% | 196 | -127 | $1,401 | $30,234,735 | 7 | Sony Pictures Releasing | false | false |
| 9 | - | New York | $260,220 | - | 34 | - | $7,653 | $260,220 | 1 | Yash Raj Films | true | false |
| 10 | - | Sunshine Cleaning | $207,805 | - | 104 | - | $1,998 | $207,805 | 1 | N/A | true | false |
| 11 | 6 | Drag Me to Hell | $182,701 | -59.8% | 173 | -143 | $1,056 | $10,461,204 | 5 | Lionsgate | false | false |
| 12 | 7 | Star Trek | $157,448 | -60.2% | 146 | -136 | $1,078 | $34,775,226 | 8 | Paramount Pictures International | false | false |
| 13 | 8 | Looking for Eric | $118,206 | -66.7% | 121 | -104 | $976 | $1,726,991 | 3 | Entertainment Film Distributors | false | false |
| 14 | 11 | Coraline | $116,267 | -44.9% | 225 | -70 | $516 | $11,968,270 | 8 | Universal Pictures International (UPI) | false | false |
| 15 | 12 | Hannah Montana: The Movie | $93,944 | -38.5% | 244 | -83 | $385 | $13,652,555 | 9 | Walt Disney Pictures | false | false |
| 16 | 9 | The Last House on the Left | $83,806 | -73.2% | 126 | -159 | $665 | $1,795,252 | 3 | Universal Pictures International (UPI) | false | false |
| 17 | - | Rudo y Cursi | $78,771 | - | 35 | - | $2,250 | $78,771 | 1 | Optimum Releasing | true | false |
| 18 | 10 | Last Chance Harvey | $74,241 | -71.8% | 115 | -127 | $645 | $3,199,656 | 4 | Momentum Pictures | false | false |
| 19 | 14 | Katyn | $22,537 | -45.6% | 13 | +1 | $1,733 | $96,253 | 2 | Artificial Eye | false | false |
| 20 | 13 | Red Cliff | $18,723 | -78.9% | 19 | -114 | $985 | $604,060 | 3 | Entertainment Film Distributors | false | false |
| 21 | 16 | Anything for Her | $12,241 | -65.6% | 13 | -10 | $941 | $410,645 | 4 | - | false | false |
| 22 | - | On Her Majesty's Secret Service 2009 Re-release | $9,923 | - | 32 | - | $310 | $9,923 | 1 | Park Circus | true | false |
| 23 | 19 | Monsters vs. Aliens | $9,756 | -29.5% | 53 | -7 | $184 | $34,933,939 | 13 | Paramount Pictures International | false | false |
| 24 | 17 | Synecdoche, New York | $9,659 | -45.6% | 11 | -4 | $878 | $828,889 | 7 | Revolver Entertainment | false | false |
| 25 | 15 | Telstar: The Joe Meek Story | $9,145 | -75.2% | 13 | -20 | $703 | $76,602 | 2 | N/A | false | false |
| 26 | 23 | In the Loop | $7,378 | -25.7% | 7 | -1 | $1,054 | $3,507,938 | 11 | Optimum Releasing | false | false |
| 27 | 22 | State of Play | $6,669 | -39.9% | 8 | -4 | $833 | $9,229,816 | 10 | Universal Pictures International (UPI) | false | false |
| 28 | - | Shirin | $6,487 | - | 2 | - | $3,243 | $6,487 | 1 | British Film Institute (BFI) | true | false |
| 29 | 18 | North by Northwest 2009 Re-release | $6,081 | -56.3% | 1 | -1 | $6,081 | $27,909 | 2 | British Film Institute (BFI) | false | false |
| 30 | 25 | X-Men Origins: Wolverine | $4,948 | -47.6% | 15 | -17 | $329 | $26,884,047 | 9 | 20th Century Fox International | false | false |
| 31 | 30 | 17 Again | $4,399 | -36.4% | 10 | -2 | $439 | $18,572,416 | 12 | Entertainment Film Distributors | false | false |
| 32 | 36 | Everlasting Moments | $3,813 | -1.6% | 6 | +1 | $635 | $95,487 | 6 | Icon Film Distribution | false | false |
| 33 | 21 | Obsessed | $3,677 | -68.8% | 6 | -11 | $612 | $854,917 | 5 | Sony Pictures Releasing | false | false |
| 34 | 32 | Is Anybody There? | $3,507 | -29.8% | 5 | -6 | $701 | $739,166 | 9 | Optimum Releasing | false | false |
| 35 | 39 | Let the Right One In | $3,405 | +1.1% | 2 | -1 | $1,702 | $1,773,906 | 12 | Momentum Pictures | false | false |
| 36 | - | Lake Tahoe | $3,187 | - | 2 | - | $1,593 | $3,187 | 1 | - | true | false |
| 37 | 41 | The End of the Line | $3,149 | +17.9% | 5 | +3 | $629 | $75,005 | 3 | Periscoop Film | false | false |
| 38 | - | Under the Sea 3D | $2,759 | - | 1 | - | $2,759 | $345,798 | 20 | IMAX | false | false |
| 39 | 28 | A Girl Cut in Two | $2,485 | -68.5% | 4 | -3 | $621 | $105,992 | 6 | Artificial Eye | false | false |
| 40 | 34 | Fermat's Room 2009 Re-release | $2,228 | -49.6% | 4 | - | $557 | $39,719 | 5 | Revolver Entertainment | false | false |
| 41 | 37 | Munde U.K. De | $2,096 | -45.1% | 2 | -1 | $1,048 | $308,483 | 8 | - | false | false |
| 42 | 38 | Chéri | $1,815 | -52% | 7 | -3 | $259 | $667,696 | 8 | Warner Bros. | false | false |
| 43 | 24 | Sleep Furiously | $1,807 | -81% | 3 | -9 | $602 | $105,780 | 5 | New Wave Films | false | false |
| 44 | 40 | The Class | $1,634 | -45.5% | 2 | - | $817 | $1,447,050 | 18 | Artificial Eye | false | false |
| 45 | 44 | Fireflies in the Garden 2008 Re-release | $1,293 | -45.9% | 3 | -4 | $431 | $93,473 | 5 | The Works UK Distribution | false | false |
| 46 | 35 | Mark of an Angel | $1,184 | -72.5% | 4 | -2 | $296 | $129,205 | 6 | - | false | false |
| 47 | 53 | The Young Victoria | $1,084 | +182.3% | 1 | - | $1,084 | $8,147,226 | 17 | Momentum Pictures | false | false |
| 48 | - | Gigantic | $999 | - | 3 | - | $333 | $12,930 | 1 | The Works UK Distribution | true | false |
| 49 | 46 | New Town Killers | $999 | -27.1% | 2 | +1 | $499 | $8,950 | 3 | N/A | false | false |
| 50 | - | The 400 Blows 2009 Re-release | $961 | - | 1 | - | $961 | $112,057 | 12 | British Film Institute (BFI) | false | false |
| 51 | - | The Last Thakur | $578 | - | 1 | - | $578 | $578 | 1 | Artificial Eye | true | false |
| 52 | - | Tenderness | $433 | - | 1 | - | $433 | $433 | 1 | Lionsgate | true | false |
| 53 | 54 | Shadows in the Sun | $342 | +32% | 1 | - | $342 | $8,963 | 4 | Artificial Eye | false | false |
| 54 | - | Dummy | $307 | - | 1 | - | $307 | $307 | 1 | N/A | true | false |
| 55 | 55 | Fifty Dead Men Walking | $238 | +12.8% | 1 | -2 | $238 | $641,867 | 12 | - | false | false |
| 56 | 52 | Awaydays | $180 | -54.1% | 1 | -1 | $180 | $131,030 | 6 | Optimum Releasing | false | false |
| 57 | - | The Blue Tower | $155 | - | 1 | - | $155 | $155 | 1 | ICA Films | true | false |
