| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $863,164 | - | 97 | - | $8,898 | $1,004,625 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Up | $447,585 | -37% | 120 | +5 | $3,729 | $2,910,353 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | Terminator Salvation | $88,141 | -57.7% | 86 | -62 | $1,024 | $1,882,270 | 4 | Sony Pictures Releasing | false | false |
| 4 | 4 | Ghosts of Girlfriends Past | $67,856 | -34.9% | 42 | - | $1,615 | $415,587 | 3 | Distribution Company | false | false |
| 5 | - | Pride and Glory | $57,293 | - | 22 | - | $2,604 | $57,293 | 1 | Distribution Company | true | false |
| 6 | 6 | State of Play | $56,946 | -43.6% | 35 | - | $1,627 | $401,655 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 7 | Felicitas | $54,573 | -36.8% | 35 | - | $1,559 | $379,645 | 3 | Pachamama Cine | false | false |
| 8 | 5 | Angels & Demons | $52,393 | -48.5% | 62 | -34 | $845 | $3,294,505 | 7 | Sony Pictures Releasing | false | false |
| 9 | 3 | Night at the Museum: Battle of the Smithsonian | $40,826 | -63.1% | 71 | -42 | $575 | $2,583,980 | 6 | 20th Century Fox International | false | false |
| 10 | 8 | The Unborn | $36,964 | -34% | 36 | - | $1,026 | $746,140 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Happy-Go-Lucky | $31,676 | -35.1% | 17 | +1 | $1,863 | $92,864 | 2 | N/A | false | false |
| 12 | 11 | The Visitor | $26,158 | -38.7% | 15 | +1 | $1,743 | $78,820 | 2 | Impacto Cine | false | false |
| 13 | 9 | Last Chance Harvey | $24,741 | -52.6% | 21 | -1 | $1,178 | $401,926 | 4 | Distribution Company | false | false |
| 14 | 13 | New in Town | $9,105 | -53.8% | 24 | -6 | $379 | $263,171 | 5 | Distribution Company | false | false |
| 15 | 15 | Inspector Bellamy | $8,578 | +3.8% | 12 | +2 | $714 | $133,501 | 4 | Alfa Films | false | false |
| 16 | 12 | Che: Part Two | $8,107 | -69% | 14 | -5 | $579 | $41,973 | 2 | Alfa Films | false | false |
| 17 | 16 | The Reader | $6,718 | -15.1% | 20 | +2 | $335 | $579,092 | 8 | Pachamama Cine | false | false |
| 18 | 28 | Adventureland | $2,482 | +118.1% | 9 | +5 | $275 | $34,326 | 4 | Walt Disney Pictures | false | false |
| 19 | 18 | The Roses of the Desert 2009 Re-release | $2,282 | -23% | 3 | -1 | $760 | $16,616 | 3 | Primer Plano Film Group | false | false |
| 20 | 27 | Fast & Furious | $1,497 | +17.6% | 3 | - | $499 | $1,901,922 | 13 | Universal Pictures International (UPI) | false | false |
| 21 | 25 | Star Trek | $1,390 | -15.3% | 6 | -2 | $231 | $410,235 | 8 | Paramount Pictures International | false | false |
| 22 | 17 | A Week Alone | $1,301 | -61.9% | 4 | -1 | $325 | $17,295 | 3 | Primer Plano Film Group | false | false |
| 23 | 19 | Race to Witch Mountain | $1,138 | -60.6% | 15 | -3 | $75 | $982,998 | 12 | Walt Disney Pictures | false | false |
| 24 | 20 | Earth | $1,135 | -60.3% | 11 | -3 | $103 | $485,765 | 10 | Walt Disney Pictures | false | false |
| 25 | 22 | Duplicity | $1,087 | -61.5% | 5 | -3 | $217 | $595,092 | 10 | Universal Pictures International (UPI) | false | false |
| 26 | 35 | The Class | $844 | +158.1% | 4 | +1 | $211 | $305,113 | 11 | Primer Plano Film Group | false | false |
| 27 | 41 | Esperando la carroza 2: Se acabó la fiesta | $569 | +2,894.7% | 2 | +1 | $284 | $1,304,101 | 13 | Primer Plano Film Group | false | false |
| 28 | 14 | All the Lonely People | $541 | -94.5% | 2 | -11 | $270 | $13,114 | 2 | Primer Plano Film Group | false | false |
| 29 | 21 | Lorna's Silence | $465 | -83.6% | 3 | -5 | $155 | $91,538 | 7 | Distribution Company | false | false |
| 30 | 26 | The Artist | $384 | -72.7% | 3 | +1 | $128 | $26,139 | 5 | Primer Plano Film Group | false | false |
| 31 | 29 | Haroldo Conti, homo viator | $359 | -43.8% | 3 | +1 | $119 | $5,706 | 5 | N/A | false | false |
| 32 | 24 | 17 Again | $314 | -83.5% | 3 | -5 | $104 | $425,375 | 8 | Distribution Company | false | false |
| 33 | 23 | Gardens in Autumn 2008 Re-release | $243 | -88.1% | 1 | -1 | $243 | $83,658 | 9 | IFA | false | false |
| 34 | 31 | The Merry Widow | $231 | -45.5% | 1 | - | $231 | $153,522 | 11 | Alfa Films | false | false |
| 35 | 36 | The Edge of Heaven | $213 | -23.1% | 1 | - | $213 | $156,550 | 15 | Alfa Films | false | false |
| 36 | 38 | Dragonball Evolution | $168 | -28.2% | 1 | - | $168 | $578,542 | 12 | 20th Century Fox International | false | false |
| 37 | 34 | Blood Appears | $97 | -73.7% | 1 | - | $97 | $25,911 | 7 | N/A | false | false |
| 38 | 40 | Rumba | $48 | -18.6% | 1 | - | $48 | $68,083 | 13 | Distribution Company | false | false |
| 39 | 33 | Slumdog Millionaire | $11 | -97.2% | 1 | -1 | $11 | $1,543,469 | 20 | Distribution Company | false | false |
