| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Ghosts of Girlfriends Past | $227,192 | -29.4% | 26 | - | $8,738 | $686,228 | 2 | Warner Bros. | false | false |
| 2 | 1 | Drag Me to Hell | $220,790 | -37.3% | 25 | -1 | $8,831 | $816,437 | 2 | Golden Village Pictures | false | false |
| 3 | 3 | Land of the Lost | $199,723 | -27.1% | 25 | - | $7,988 | $577,069 | 3 | United International Pictures | false | false |
| 4 | 4 | The Taking of Pelham 123 | $184,045 | -27.8% | 27 | - | $6,816 | $521,662 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | I Love You, Man | $135,012 | - | 16 | - | $8,438 | $148,570 | 1 | United International Pictures | true | false |
| 6 | 5 | Monsters vs. Aliens | $123,031 | -27.5% | 28 | -3 | $4,393 | $1,835,528 | 4 | United International Pictures | false | false |
| 7 | 6 | Night at the Museum: Battle of the Smithsonian | $92,984 | -20.7% | 27 | -4 | $3,443 | $2,959,704 | 5 | 20th Century Fox International | false | false |
| 8 | 7 | Terminator Salvation | $78,632 | -32.3% | 28 | -8 | $2,808 | $2,040,789 | 4 | Sony Pictures Releasing | false | false |
| 9 | 8 | Blood: The Last Vampire | $28,752 | -56.4% | 6 | -9 | $4,792 | $376,115 | 3 | Cathay-Keris Films | false | false |
| 10 | 9 | Hannah Montana: The Movie | $26,920 | -54.3% | 21 | -3 | $1,281 | $307,460 | 3 | Walt Disney Pictures | false | false |
| 11 | 10 | State of Play | $24,262 | -45.5% | 12 | -2 | $2,021 | $231,543 | 2 | United International Pictures | false | false |
| 12 | 11 | Angels & Demons | $20,508 | +14.2% | 9 | -2 | $2,278 | $2,157,290 | 6 | Sony Pictures Releasing | false | false |
| 13 | - | Trail of the Panda | $16,689 | - | 5 | - | $3,337 | $16,689 | 110 | Walt Disney Pictures | false | false |
| 14 | 12 | Dance Subaru | $10,582 | -32.6% | 2 | - | $5,291 | $105,793 | 4 | Cathay-Keris Films | false | false |
| 15 | 15 | Star Trek | $3,133 | +19.8% | 2 | -1 | $1,566 | $1,195,561 | 7 | United International Pictures | false | false |
| 16 | 16 | Nobody to Watch Over Me | $2,489 | +11% | 1 | - | $2,489 | $6,001 | 2 | Cathay-Keris Films | false | false |
| 17 | 14 | Man on Wire | $2,198 | -21.6% | 1 | - | $2,198 | $11,755 | 3 | Golden Village Pictures | false | false |
| 18 | 18 | The Baader Meinhof Complex | $963 | +44.6% | 1 | - | $963 | $17,193 | 5 | Golden Village Pictures | false | false |
