| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Proposal | $29,339 | - | 7 | - | $4,191 | $32,410 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | The Hangover | $26,803 | -51% | 7 | - | $3,829 | $133,824 | 2 | - | false | false |
| 3 | 2 | Terminator Salvation | $8,378 | -63.8% | 7 | -3 | $1,196 | $158,678 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Drag Me to Hell | $6,839 | -69.6% | 5 | - | $1,367 | $49,120 | 2 | ACME | false | false |
| 5 | 4 | Angels & Demons | $3,833 | -66.3% | 6 | -1 | $638 | $286,037 | 6 | Sony Pictures Releasing | false | false |
| 6 | 5 | New in Town | $2,645 | -72.1% | 5 | - | $529 | $45,084 | 3 | ACME | false | false |
| 7 | 6 | Night at the Museum: Battle of the Smithsonian | $2,534 | -68.4% | 8 | - | $316 | $96,621 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 9 | Monsters vs. Aliens | $2,336 | -26.6% | 6 | - | $389 | $219,755 | 12 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Fighting | $1,884 | -71.1% | 7 | - | $269 | $74,698 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Ghosts of Girlfriends Past | $1,490 | -75.4% | 5 | -2 | $298 | $63,965 | 4 | - | false | false |
| 11 | - | State of Play | $981 | - | 1 | - | $981 | $1,205 | 1 | Universal Pictures International (UPI) | true | false |
| 12 | 11 | Coraline | $931 | -47.8% | 2 | - | $465 | $47,728 | 7 | Universal Pictures International (UPI) | false | false |
| 13 | 14 | My Bloody Valentine | $632 | -1.7% | 1 | - | $632 | $123,081 | 9 | ACME | false | false |
| 14 | 12 | The Tale of Despereaux | $508 | -38.4% | 5 | - | $101 | $281,954 | 26 | Universal Pictures International (UPI) | false | false |
| 15 | 10 | Jonas Brothers: The 3D Concert Experience | $254 | -86.3% | 2 | - | $127 | $3,849 | 2 | Universal Pictures International (UPI) | false | false |
| 16 | - | Bolt | $238 | - | 3 | - | $79 | $328,313 | 17 | Universal Pictures International (UPI) | false | false |
| 17 | 17 | The Uninvited | $222 | -45.3% | 1 | - | $222 | $20,302 | 5 | Universal Pictures International (UPI) | false | false |
| 18 | 21 | Observe and Report | $187 | -11% | 3 | +2 | $62 | $22,784 | 6 | - | false | false |
| 19 | 13 | Home | $179 | -74.4% | 1 | - | $179 | - | 3 | N/A | false | false |
| 20 | 20 | 17 Again | $172 | -47.4% | 2 | -3 | $86 | $131,370 | 7 | - | false | false |
| 21 | 18 | Delta | $155 | -60.1% | 1 | - | $155 | - | 4 | N/A | false | false |
| 22 | 22 | Madagascar: Escape 2 Africa | $130 | -38.1% | 1 | - | $130 | $751,492 | 30 | Universal Pictures International (UPI) | false | false |
| 23 | 27 | Kung Fu Panda | $101 | +42.3% | 1 | - | $101 | $482,075 | 55 | Universal Pictures International (UPI) | false | false |
| 24 | 19 | Ice Age: The Meltdown | $80 | -78.6% | 2 | - | $40 | $665,174 | 168 | Universal Pictures International (UPI) | false | false |
| 25 | 25 | X-Men Origins: Wolverine | $63 | -16% | 2 | -1 | $31 | $61,702 | 8 | Universal Pictures International (UPI) | false | false |
| 26 | - | Hotel for Dogs | $37 | - | 1 | - | $37 | $49,729 | 14 | Universal Pictures International (UPI) | false | false |
| 27 | 31 | I Love You, Man | $29 | -6.5% | 1 | - | $29 | $37,036 | 9 | Universal Pictures International (UPI) | false | false |
| 28 | 29 | Fast & Furious | $24 | -42.9% | 1 | - | $24 | $374,527 | 12 | Universal Pictures International (UPI) | false | false |
| 29 | 26 | Star Trek | $18 | -75.7% | 1 | - | $18 | $24,798 | 7 | Universal Pictures International (UPI) | false | false |
| 30 | - | The Crimson Wing: Mystery of the Flamingos | $11 | - | 1 | - | $11 | $23,572 | 15 | Universal Pictures International (UPI) | false | false |
| 31 | 32 | Newsmakers | $7 | -69.6% | 1 | - | $7 | $7,321 | 7 | N/A | false | false |
