| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $710,298 | -32.1% | 115 | +3 | $6,176 | $2,300,368 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | Terminator Salvation | $208,577 | -48.5% | 148 | - | $1,409 | $1,732,277 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | Night at the Museum: Battle of the Smithsonian | $110,688 | -44% | 113 | -2 | $979 | $2,543,154 | 5 | 20th Century Fox International | false | false |
| 4 | 6 | Ghosts of Girlfriends Past | $104,275 | -32.8% | 42 | - | $2,482 | $324,467 | 2 | Distribution Company | false | false |
| 5 | 4 | Angels & Demons | $101,770 | -47.4% | 96 | - | $1,060 | $3,216,752 | 6 | Sony Pictures Releasing | false | false |
| 6 | 5 | State of Play | $101,028 | -37% | 35 | - | $2,886 | $322,450 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 7 | Felicitas | $86,299 | -40.7% | 35 | - | $2,465 | $299,473 | 2 | Pachamama Cine | false | false |
| 8 | 9 | The Unborn | $55,966 | -7% | 36 | +5 | $1,554 | $696,748 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Last Chance Harvey | $52,231 | -49.4% | 22 | - | $2,374 | $365,552 | 3 | Distribution Company | false | false |
| 10 | - | Happy-Go-Lucky | $48,801 | - | 16 | - | $3,050 | $48,801 | 1 | N/A | true | false |
| 11 | - | The Visitor | $42,671 | - | 14 | - | $3,047 | $42,671 | 1 | Impacto Cine | true | false |
| 12 | - | Che: Part Two | $26,181 | - | 19 | - | $1,377 | $26,181 | 1 | Alfa Films | true | false |
| 13 | 12 | New in Town | $19,727 | +13.1% | 30 | +10 | $657 | $250,301 | 4 | Distribution Company | false | false |
| 14 | - | All the Lonely People | $9,833 | - | 13 | - | $756 | $9,833 | 1 | Primer Plano Film Group | true | false |
| 15 | 10 | Inspector Bellamy | $8,267 | -72.5% | 10 | -3 | $826 | $122,789 | 3 | Alfa Films | false | false |
| 16 | 11 | The Reader | $7,913 | -55.9% | 18 | - | $439 | $569,081 | 7 | Pachamama Cine | false | false |
| 17 | 13 | A Week Alone | $3,416 | -56.9% | 5 | - | $683 | $14,945 | 2 | Primer Plano Film Group | false | false |
| 18 | 14 | The Roses of the Desert 2009 Re-release | $2,965 | -55.7% | 4 | - | $741 | $13,213 | 2 | Primer Plano Film Group | false | false |
| 19 | 16 | Race to Witch Mountain | $2,886 | -45.2% | 18 | -13 | $160 | $981,174 | 11 | Walt Disney Pictures | false | false |
| 20 | 15 | Earth | $2,856 | -55.4% | 14 | -7 | $204 | $483,001 | 9 | Walt Disney Pictures | false | false |
| 21 | 28 | Lorna's Silence | $2,836 | +288.5% | 8 | +5 | $354 | $90,379 | 6 | Distribution Company | false | false |
| 22 | 18 | Duplicity | $2,824 | -4.6% | 8 | +3 | $353 | $593,456 | 9 | Universal Pictures International (UPI) | false | false |
| 23 | 19 | Gardens in Autumn 2008 Re-release | $2,039 | -15.2% | 2 | -1 | $1,019 | $83,138 | 8 | IFA | false | false |
| 24 | 27 | 17 Again | $1,898 | +155.5% | 8 | +5 | $237 | $424,517 | 7 | Distribution Company | false | false |
| 25 | 34 | Star Trek | $1,641 | +378.4% | 8 | +6 | $205 | $408,327 | 7 | Paramount Pictures International | false | false |
| 26 | 21 | The Artist | $1,409 | +6% | 2 | - | $704 | $25,349 | 4 | Primer Plano Film Group | false | false |
| 27 | 22 | Fast & Furious | $1,273 | -2.3% | 3 | -3 | $424 | $1,900,053 | 12 | Universal Pictures International (UPI) | false | false |
| 28 | 17 | Adventureland | $1,138 | -64.2% | 4 | +2 | $284 | $31,706 | 3 | Walt Disney Pictures | false | false |
| 29 | 20 | Haroldo Conti, homo viator | $639 | -58.3% | 2 | -1 | $319 | $5,068 | 4 | N/A | false | false |
| 30 | 26 | X-Men Origins: Wolverine | $608 | -21.8% | 2 | -1 | $304 | $1,725,740 | 8 | 20th Century Fox International | false | false |
| 31 | 24 | The Merry Widow | $424 | -47.2% | 1 | -1 | $424 | $153,109 | 10 | Alfa Films | false | false |
| 32 | 33 | Luisa | $410 | +15.2% | 3 | +2 | $136 | $14,253 | 7 | Primer Plano Film Group | false | false |
| 33 | 37 | Slumdog Millionaire | $391 | +287.1% | 2 | +1 | $195 | $1,543,429 | 19 | Distribution Company | false | false |
| 34 | 25 | Blood Appears | $369 | -53.9% | 1 | - | $369 | $25,661 | 6 | N/A | false | false |
| 35 | 23 | The Class | $327 | -68.1% | 3 | +1 | $109 | $304,142 | 10 | Primer Plano Film Group | false | false |
| 36 | 32 | The Edge of Heaven | $277 | -23.7% | 1 | - | $277 | $156,284 | 14 | Alfa Films | false | false |
| 37 | 35 | Monsters vs. Aliens | $276 | -19.1% | 3 | +1 | $92 | $1,596,237 | 12 | Paramount Pictures International | false | false |
| 38 | 31 | Dragonball Evolution | $234 | -52.7% | 1 | -2 | $234 | $578,325 | 11 | 20th Century Fox International | false | false |
| 39 | 42 | Gomorrah | $67 | +219% | 2 | +1 | $33 | $254,128 | 15 | Alfa Films | false | false |
| 40 | 38 | Rumba | $59 | -26.2% | 1 | - | $59 | $68,021 | 12 | Distribution Company | false | false |
| 41 | 30 | Esperando la carroza 2: Se acabó la fiesta | $19 | -97% | 1 | -2 | $19 | $1,303,532 | 12 | Primer Plano Film Group | false | false |
| 42 | 40 | Vicky Cristina Barcelona | $16 | -72.9% | 1 | - | $16 | $772,228 | 20 | Pachamama Cine | false | false |
| 43 | 29 | The Accidental Husband | $13 | -98.1% | 1 | -3 | $13 | $225,379 | 8 | Walt Disney Pictures | false | false |
