| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Hangover | $2,795,349 | - | 226 | - | $12,368 | $2,826,821 | 1 | Warner Bros. | true | false |
| 2 | 1 | Terminator Salvation | $1,889,599 | -63.3% | 386 | - | $4,895 | $9,049,503 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Land of the Lost | $1,241,136 | - | 219 | - | $5,667 | $1,339,592 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Night at the Museum: Battle of the Smithsonian | $971,046 | -47% | 318 | -61 | $3,053 | $11,690,948 | 4 | 20th Century Fox International | false | false |
| 5 | 3 | I Love You, Man | $590,821 | -52.4% | 187 | +1 | $3,159 | $2,819,398 | 2 | Paramount Pictures International | false | false |
| 6 | 4 | State of Play | $580,145 | -43.1% | 223 | -22 | $2,601 | $4,377,826 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 5 | Angels & Demons | $545,429 | -44.3% | 290 | -58 | $1,880 | $13,514,836 | 5 | Sony Pictures Releasing | false | false |
| 8 | 6 | Star Trek | $279,050 | -47.6% | 169 | -60 | $1,651 | $12,366,950 | 6 | Paramount Pictures International | false | false |
| 9 | 7 | Samson & Delilah | $167,902 | -28.5% | 38 | - | $4,418 | $1,624,278 | 6 | Paramount Pictures International | false | false |
| 10 | - | Sunshine Cleaning | $159,589 | - | 55 | - | $2,901 | $212,719 | 1 | Madman Entertainment | true | false |
| 11 | 8 | Ghosts of Girlfriends Past | $97,628 | -57.4% | 96 | -41 | $1,016 | $5,208,483 | 6 | Roadshow Films | false | false |
| 12 | 11 | Is Anybody There? | $80,957 | -27.3% | 32 | - | $2,529 | $298,377 | 2 | Hopscotch Films | false | false |
| 13 | 10 | My Year Without Sex | $78,465 | -36.6% | 25 | - | $3,138 | $510,526 | 4 | Paramount Pictures International | false | false |
| 14 | 9 | X-Men Origins: Wolverine | $69,514 | -68.2% | 86 | -74 | $808 | $14,977,846 | 7 | 20th Century Fox International | false | false |
| 15 | 12 | The Boy in the Striped Pajamas | $37,002 | -46.2% | 54 | -17 | $685 | $2,910,845 | 8 | Walt Disney Pictures | false | false |
| 16 | 17 | Under the Sea 3D | $26,187 | -9.8% | 2 | - | $13,093 | $678,717 | 16 | IMAX | false | false |
| 17 | 18 | Two Lovers | $24,146 | -15.8% | 3 | - | $8,048 | $70,572 | 2 | Roadshow Films | false | false |
| 18 | 13 | Defiance | $18,693 | -58.2% | 38 | -23 | $491 | $2,934,207 | 7 | Roadshow Films | false | false |
| 19 | 15 | Gomorrah | $16,928 | -49.8% | 15 | -4 | $1,128 | $354,349 | 5 | Madman Entertainment | false | false |
| 20 | - | The Merchant of Venice 2009 Re-release | $13,828 | - | 7 | - | $1,975 | $16,527 | 1 | Arkles Entertainment | true | false |
| 21 | - | Shall We Kiss? | $10,938 | - | 8 | - | $1,367 | $10,938 | 1 | N/A | true | false |
| 22 | - | Noodle | $1,569 | - | 4 | - | $392 | $1,569 | - | Potential Films | - | false |
