| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $958,811 | - | 89 | - | $10,773 | $1,184,736 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Terminator Salvation | $596,253 | - | 85 | - | $7,014 | $596,253 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Night at the Museum: Battle of the Smithsonian | $426,864 | -45.8% | 66 | -16 | $6,467 | $2,953,748 | 3 | 20th Century Fox International | false | false |
| 4 | 2 | Angels & Demons | $311,537 | -39.5% | 71 | -13 | $4,387 | $3,423,416 | 4 | Sony Pictures Releasing | false | false |
| 5 | 3 | Knowing | $120,737 | -40% | 38 | -3 | $3,177 | $454,444 | 2 | N/A | false | false |
| 6 | 4 | Race to Witch Mountain | $28,243 | -64.8% | 24 | -11 | $1,176 | $1,741,423 | 6 | Walt Disney Pictures | false | false |
| 7 | 6 | Flawless | $20,026 | -59.2% | 7 | -5 | $2,860 | $135,965 | 2 | N/A | false | false |
| 8 | 12 | Paris, Je T'aime | $13,828 | -2.6% | 3 | - | $4,609 | $104,742 | 4 | N/A | false | false |
| 9 | 7 | The Accidental Husband | $8,356 | -81.3% | 6 | -17 | $1,392 | $480,058 | 4 | Walt Disney Pictures | false | false |
| 10 | 14 | The Diving Bell and the Butterfly | $8,141 | -18.9% | 1 | -1 | $8,141 | $53,831 | 3 | N/A | false | false |
| 11 | 5 | X-Men Origins: Wolverine | $6,416 | -89% | 6 | -39 | $1,069 | $2,516,584 | 6 | 20th Century Fox International | false | false |
| 12 | 10 | Coraline | $4,476 | -79% | 12 | -16 | $373 | $540,518 | 5 | United International Pictures | false | false |
| 13 | 11 | Star Trek | $3,580 | -80.9% | 13 | +6 | $275 | $568,721 | 5 | United International Pictures | false | false |
| 14 | 13 | Earth | $3,528 | -73.3% | 6 | -4 | $588 | $362,798 | 7 | Walt Disney Pictures | false | false |
| 15 | 23 | Slumdog Millionaire | $947 | -30.9% | 1 | -3 | $947 | $1,748,182 | 15 | N/A | false | false |
| 16 | 21 | The Pope's Toilet | $910 | -55.8% | 1 | -2 | $910 | $4,366 | 2 | N/A | false | false |
| 17 | 16 | The Strangers | $599 | -92.7% | 2 | -6 | $299 | $482,590 | 7 | N/A | false | false |
| 18 | 20 | Monsters vs. Aliens | $408 | -84.9% | 3 | -3 | $136 | $3,033,291 | 10 | United International Pictures | false | false |
| 19 | 15 | Fast & Furious | $315 | -96.3% | 3 | -11 | $105 | $4,603,220 | 10 | United International Pictures | false | false |
| 20 | 18 | He's Just Not That Into You | $238 | -95.8% | 1 | -5 | $238 | $513,386 | 6 | N/A | false | false |
| 21 | 19 | Inkheart | $63 | -98% | 1 | -9 | $63 | $953,627 | 11 | N/A | false | false |
| 22 | 22 | Swing con son | $36 | -98.2% | 1 | -3 | $36 | $71,452 | 7 | N/A | false | false |
