| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $370,027 | - | 55 | - | $6,727 | $384,665 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Night at the Museum: Battle of the Smithsonian | $155,280 | -45.7% | 60 | - | $2,588 | $1,071,488 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | The Unborn | $99,501 | -46.7% | 32 | - | $3,109 | $365,263 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Angels & Demons | $62,687 | -53.3% | 42 | -10 | $1,492 | $1,267,020 | 4 | Sony Pictures Releasing | false | false |
| 5 | - | Sex Drive | $46,429 | - | 22 | - | $2,110 | $46,429 | 1 | N/A | true | false |
| 6 | 4 | The Accidental Husband | $34,438 | -54.6% | 24 | - | $1,434 | $141,533 | 2 | Walt Disney Pictures | false | false |
| 7 | - | Dan in Real Life | $29,738 | - | 12 | - | $2,478 | $29,738 | 1 | N/A | true | false |
| 8 | 6 | Hannah Montana: The Movie | $23,033 | -18.6% | 26 | - | $885 | $510,102 | 5 | Walt Disney Pictures | false | false |
| 9 | 20 | 17 Again | $13,683 | +918.8% | 20 | - | $684 | $295,493 | 6 | Warner Bros. | false | false |
| 10 | 7 | Fireflies in the Garden 2008 Re-release | $9,630 | -24.3% | 5 | - | $1,926 | $28,051 | 2 | N/A | false | false |
| 11 | 5 | Ghosts of Girlfriends Past | $8,200 | -74.5% | 22 | - | $372 | $266,194 | 4 | Warner Bros. | false | false |
| 12 | 12 | The Ugly Duckling and Me! | $5,212 | -24.7% | 20 | - | $260 | $132,033 | 13 | N/A | false | false |
| 13 | - | The Boy in the Striped Pajamas | $3,699 | - | 8 | - | $462 | $108,093 | 14 | Walt Disney Pictures | false | false |
| 14 | 8 | Star Trek | $1,892 | -81.6% | 40 | - | $47 | $418,859 | 5 | Paramount Pictures International | false | false |
| 15 | - | Death Defying Acts | $1,532 | - | 14 | - | $109 | $72,544 | 7 | N/A | false | false |
| 16 | 16 | Fast & Furious | $1,388 | -37.9% | 25 | - | $55 | $668,172 | 10 | Universal Pictures International (UPI) | false | false |
| 17 | 9 | My Bloody Valentine | $1,040 | -89.4% | 25 | - | $41 | $477,345 | 6 | N/A | false | false |
| 18 | 22 | Confessions of a Shopaholic | $1,021 | +114% | 24 | - | $42 | $225,410 | 11 | Walt Disney Pictures | false | false |
| 19 | 13 | The Prize | $65 | -98.8% | 20 | - | $3 | $118,410 | 6 | N/A | false | false |
| 20 | 11 | Funny Games | $55 | -99.2% | 15 | - | $3 | $49,970 | 3 | N/A | false | false |
