| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $7,636,415 | - | 489 | - | $15,616 | $11,081,955 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Night at the Museum: Battle of the Smithsonian | $3,857,601 | +16% | 509 | -11 | $7,578 | $24,672,757 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Drag Me to Hell | $2,054,963 | -33.4% | 408 | +11 | $5,036 | $6,507,991 | 2 | Lionsgate | false | false |
| 4 | 3 | Angels & Demons | $1,712,672 | +1% | 454 | -58 | $3,772 | $25,756,093 | 4 | Sony Pictures Releasing | false | false |
| 5 | 4 | Star Trek | $1,363,079 | -2.8% | 423 | -36 | $3,222 | $31,095,889 | 5 | Paramount Pictures International | false | false |
| 6 | - | Last Chance Harvey | $1,023,102 | - | 302 | - | $3,387 | $1,023,102 | 1 | Momentum Pictures | true | false |
| 7 | 6 | Coraline | $591,207 | +29.8% | 392 | -40 | $1,508 | $10,783,016 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Hannah Montana: The Movie | $411,843 | +0.9% | 419 | -30 | $982 | $12,664,990 | 6 | Walt Disney Pictures | false | false |
| 9 | 5 | 12 Rounds | $234,243 | -55.7% | 291 | -9 | $804 | $979,269 | 2 | 20th Century Fox International | false | false |
| 10 | 8 | X-Men Origins: Wolverine | $211,201 | -40.7% | 208 | -106 | $1,015 | $25,828,649 | 6 | 20th Century Fox International | false | false |
| 11 | 9 | Obsessed | $203,994 | -18.3% | 131 | -18 | $1,557 | $629,230 | 2 | Sony Pictures Releasing | false | false |
| 12 | - | Anything for Her | $142,935 | - | 43 | - | $3,324 | $142,935 | 1 | Metrodome Distribution | true | false |
| 13 | 10 | Jonas Brothers: The 3D Concert Experience | $108,932 | -42.5% | 161 | -8 | $676 | $356,313 | 2 | Walt Disney Pictures | false | false |
| 14 | 14 | Synecdoche, New York | $52,362 | -8% | 28 | -12 | $1,870 | $694,515 | 4 | Revolver Entertainment | false | false |
| 15 | 15 | Monsters vs. Aliens | $50,828 | -5.8% | 110 | -108 | $462 | $33,731,182 | 10 | Paramount Pictures International | false | false |
| 16 | 17 | In the Loop | $28,411 | +13.3% | 18 | -13 | $1,578 | $3,316,401 | 8 | Optimum Releasing | false | false |
| 17 | 11 | Tormented | $24,851 | -75.2% | 59 | -158 | $421 | $1,100,729 | 3 | Warner Bros. | false | false |
| 18 | 18 | Sleep Furiously | $18,109 | -4.2% | 10 | +1 | $1,810 | $54,399 | 2 | New Wave Films | false | false |
| 19 | 22 | Is Anybody There? | $15,205 | +143.7% | 22 | +5 | $691 | $666,883 | 6 | Optimum Releasing | false | false |
| 20 | - | Sugar | $12,669 | - | 1 | - | $12,669 | $12,669 | 1 | Axiom Films | true | false |
| 21 | 19 | Chéri | $10,236 | -11.2% | 17 | -5 | $602 | $601,304 | 5 | Warner Bros. | false | false |
| 22 | - | Accident | $8,779 | - | 1 | - | $8,779 | $8,779 | 1 | British Film Institute (BFI) | true | false |
| 23 | 27 | The Boat That Rocked | $7,538 | +127.5% | 4 | +1 | $1,884 | $9,784,855 | 10 | Universal Pictures International (UPI) | false | false |
| 24 | 23 | The Young Victoria | $5,173 | -8.6% | 3 | -1 | $1,724 | $7,874,742 | 14 | Momentum Pictures | false | false |
| 25 | 20 | Awaydays | $3,876 | -45.8% | 10 | -12 | $387 | $121,609 | 3 | Optimum Releasing | false | false |
| 26 | 26 | The Damned United | $2,440 | -38.2% | 5 | - | $488 | $3,478,600 | 11 | Sony Pictures Releasing | false | false |
| 27 | - | Shadows in the Sun | $2,219 | - | 2 | - | $1,109 | $2,219 | 1 | Artificial Eye | true | false |
| 28 | 21 | Slumdog Millionaire | $2,139 | -66.9% | 2 | -4 | $1,069 | $50,585,521 | 22 | Pathé | false | false |
| 29 | 32 | Fifty Dead Men Walking | $1,019 | +113.6% | 4 | +2 | $254 | $615,540 | 9 | Metrodome Distribution | false | false |
| 30 | - | The Hide | $891 | - | 1 | - | $891 | $891 | 1 | ICA Films | true | false |
| 31 | 31 | Shifty | $832 | +43.2% | 3 | +1 | $277 | $229,158 | 7 | Metrodome Distribution | false | false |
| 32 | - | This Sporting Life | $813 | - | 2 | - | $406 | $813 | - | Park Circus | - | false |
| 33 | 28 | Sounds Like Teen Spirit | $633 | -78.7% | 6 | -3 | $105 | $35,768 | 5 | - | false | false |
