| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $787,730 | -11.9% | 82 | - | $9,606 | $2,145,936 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Angels & Demons | $514,690 | -16.2% | 84 | +1 | $6,127 | $2,781,346 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | Knowing | $201,212 | - | 41 | - | $4,907 | $203,501 | 1 | N/A | true | false |
| 4 | 4 | Race to Witch Mountain | $80,319 | -41.8% | 35 | -4 | $2,294 | $1,637,336 | 5 | Walt Disney Pictures | false | false |
| 5 | 3 | X-Men Origins: Wolverine | $58,302 | -61% | 45 | +3 | $1,295 | $2,474,400 | 5 | 20th Century Fox International | false | false |
| 6 | - | Flawless | $49,033 | - | 12 | - | $4,086 | $82,188 | 1 | N/A | true | false |
| 7 | 5 | The Accidental Husband | $44,784 | -46.6% | 23 | -3 | $1,947 | $436,223 | 3 | Walt Disney Pictures | false | false |
| 8 | 7 | Solstice | $44,359 | -28.1% | 14 | -1 | $3,168 | $143,564 | 2 | N/A | false | false |
| 9 | - | Swing Vote | $26,889 | - | 10 | - | $2,688 | $32,994 | 1 | N/A | true | false |
| 10 | 6 | Coraline | $21,363 | -71.5% | 28 | -1 | $762 | $523,794 | 4 | United International Pictures | false | false |
| 11 | 8 | Star Trek | $18,772 | -53.4% | 7 | -6 | $2,681 | $552,893 | 4 | United International Pictures | false | false |
| 12 | 11 | Paris, Je T'aime | $14,196 | -15% | 3 | - | $4,732 | $81,859 | 3 | N/A | false | false |
| 13 | 12 | Earth | $13,231 | -13.8% | 10 | - | $1,323 | $352,109 | 6 | Walt Disney Pictures | false | false |
| 14 | 13 | The Diving Bell and the Butterfly | $10,034 | -31.8% | 2 | -1 | $5,017 | $41,212 | 2 | N/A | false | false |
| 15 | 9 | Fast & Furious | $8,490 | -77.5% | 14 | -14 | $606 | $4,592,606 | 9 | United International Pictures | false | false |
| 16 | 14 | The Strangers | $8,252 | -26.9% | 8 | - | $1,031 | $477,300 | 6 | N/A | false | false |
| 17 | 19 | Catacombs | $7,328 | +74.6% | 6 | +2 | $1,221 | $216,775 | 6 | N/A | false | false |
| 18 | 10 | He's Just Not That Into You | $5,605 | -77.8% | 6 | -7 | $934 | $507,083 | 5 | N/A | false | false |
| 19 | 16 | Inkheart | $3,135 | -55.1% | 10 | -2 | $313 | $951,499 | 10 | N/A | false | false |
| 20 | 15 | Monsters vs. Aliens | $2,710 | -63.1% | 6 | -7 | $451 | $3,031,475 | 9 | United International Pictures | false | false |
| 21 | - | The Pope's Toilet | $2,060 | - | 3 | - | $686 | $2,060 | 1 | N/A | true | false |
| 22 | 18 | Swing con son | $1,971 | -53.9% | 4 | - | $492 | $68,894 | 6 | N/A | false | false |
| 23 | 20 | Slumdog Millionaire | $1,371 | -32.3% | 4 | -1 | $342 | $1,744,127 | 14 | N/A | false | false |
| 24 | 23 | Sex Drive | $1,297 | +117.3% | 2 | - | $648 | $212,030 | 7 | N/A | false | false |
| 25 | 17 | Balls of Fury | $966 | -83.5% | 4 | -3 | $241 | $238,255 | 7 | N/A | false | false |
| 26 | 21 | Underworld: Rise of the Lycans | $503 | -72.9% | 2 | - | $251 | $1,033,059 | 10 | Sony Pictures Releasing | false | false |
| 27 | 22 | Milk | $430 | -75.3% | 2 | -2 | $215 | $65,571 | 4 | United International Pictures | false | false |
