| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $285,826 | -32% | 60 | - | $4,763 | $831,327 | 2 | 20th Century Fox International | false | false |
| 2 | - | The Unborn | $186,539 | - | 32 | - | $5,829 | $186,539 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | Angels & Demons | $134,194 | -46.3% | 52 | - | $2,580 | $1,153,595 | 3 | Sony Pictures Releasing | false | false |
| 4 | - | The Accidental Husband | $75,860 | - | 24 | - | $3,160 | $75,860 | 1 | Walt Disney Pictures | true | false |
| 5 | 3 | Ghosts of Girlfriends Past | $32,094 | -41.8% | 22 | - | $1,458 | $245,544 | 3 | Warner Bros. | false | false |
| 6 | 4 | Hannah Montana: The Movie | $28,311 | -44.8% | 26 | - | $1,088 | $479,333 | 4 | Walt Disney Pictures | false | false |
| 7 | - | Fireflies in the Garden 2008 Re-release | $12,721 | - | 5 | - | $2,544 | $12,721 | 1 | N/A | true | false |
| 8 | 5 | Star Trek | $10,289 | -64.2% | 40 | - | $257 | $414,281 | 4 | Paramount Pictures International | false | false |
| 9 | 8 | My Bloody Valentine | $9,808 | -58.8% | 25 | - | $392 | $473,038 | 5 | N/A | false | false |
| 10 | 6 | The Wrestler | $9,680 | -64.2% | 14 | - | $691 | $48,496 | 2 | N/A | false | false |
| 11 | 7 | Funny Games | $7,273 | -72.7% | 15 | - | $484 | $46,104 | 2 | N/A | false | false |
| 12 | - | The Ugly Duckling and Me! | $6,925 | - | 20 | - | $346 | $123,483 | 12 | N/A | false | false |
| 13 | 22 | The Prize | $5,421 | +1,377.1% | 20 | - | $271 | $115,551 | 5 | N/A | false | false |
| 14 | - | Mad Money | $4,474 | - | 8 | - | $559 | $70,106 | 15 | N/A | false | false |
| 15 | 9 | X-Men Origins: Wolverine | $3,457 | -80.7% | 60 | - | $57 | $867,258 | 5 | 20th Century Fox International | false | false |
| 16 | 10 | Fast & Furious | $2,235 | -85.4% | 25 | - | $89 | $657,945 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | 12 | The Women | $1,622 | -46.3% | 14 | - | $115 | $105,118 | 11 | N/A | false | false |
| 18 | 17 | Race to Witch Mountain | $1,399 | -0.1% | 36 | - | $38 | $867,052 | 8 | Walt Disney Pictures | false | false |
| 19 | 13 | Flawless | $1,390 | -51.4% | 12 | - | $115 | $71,958 | 4 | N/A | false | false |
| 20 | 14 | 17 Again | $1,343 | -49.6% | 20 | - | $67 | $276,390 | 5 | Warner Bros. | false | false |
| 21 | 20 | The Counterfeiters | $598 | -1.2% | 7 | - | $85 | $41,851 | 5 | N/A | false | false |
| 22 | 21 | Confessions of a Shopaholic | $477 | -20.9% | 24 | - | $19 | $224,164 | 10 | Walt Disney Pictures | false | false |
| 23 | - | Space Chimps | $205 | - | 25 | - | $8 | $207,357 | 14 | N/A | false | false |
| 24 | 11 | Monsters vs. Aliens | $55 | -98.9% | 48 | - | $1 | $964,561 | 9 | Paramount Pictures International | false | false |
