| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $2,529,082 | -21.8% | 811 | -7 | $3,118 | $20,752,731 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Night at the Museum: Battle of the Smithsonian | $2,100,342 | +15.5% | 492 | -26 | $4,268 | $4,605,356 | 2 | 20th Century Fox International | false | false |
| 3 | - | The Girl with the Dragon Tattoo | $1,304,955 | - | 437 | - | $2,986 | $1,331,588 | 1 | BIM Distribuzione | true | false |
| 4 | 4 | Vincere | $546,968 | -8.8% | 291 | -11 | $1,879 | $1,562,119 | 2 | 01 Distribution | false | false |
| 5 | - | Coco Before Chanel | $434,623 | - | 163 | - | $2,666 | $434,623 | 1 | Warner Bros. | true | false |
| 6 | 3 | My Bloody Valentine | $396,853 | -37% | 95 | -85 | $4,177 | $7,717,455 | 4 | Medusa Distribuzione | false | false |
| 7 | 5 | 17 Again | $262,817 | -26.9% | 166 | -137 | $1,583 | $1,812,249 | 3 | Warner Bros. | false | false |
| 8 | 7 | Antichrist | $149,002 | -13.4% | 115 | -6 | $1,295 | $442,195 | 2 | Lucky Red | false | false |
| 9 | - | Battle for Terra | $118,638 | - | 130 | - | $912 | $118,638 | 1 | Sony Pictures Releasing | true | false |
| 10 | 6 | Star Trek | $107,587 | -42.9% | 69 | -94 | $1,559 | $3,013,373 | 4 | United International Pictures | false | false |
| 11 | - | The Uninvited | $73,717 | - | 50 | - | $1,474 | $73,717 | 1 | United International Pictures | true | false |
| 12 | 9 | State of Play | $55,316 | -39.5% | 33 | -46 | $1,676 | $3,250,998 | 5 | United International Pictures | false | false |
| 13 | 8 | X-Men Origins: Wolverine | $44,470 | -62.1% | 37 | -87 | $1,201 | $6,945,272 | 5 | 20th Century Fox International | false | false |
| 14 | 12 | Questione di cuore | $32,367 | -27.9% | 18 | -12 | $1,798 | $3,647,434 | 7 | 01 Distribution | false | false |
| 15 | 14 | Gran Torino | $29,882 | +11.2% | 18 | -5 | $1,660 | $12,510,260 | 12 | Warner Bros. | false | false |
| 16 | - | Cloud 9 | $27,919 | - | 17 | - | $1,642 | $27,919 | 1 | Warner Bros. | true | false |
| 17 | 10 | Hannah Montana: The Movie | $22,605 | -57.7% | 30 | -85 | $753 | $3,279,336 | 5 | Walt Disney Pictures | false | false |
| 18 | 19 | Earth | $14,805 | -14% | 24 | -21 | $616 | $1,014,045 | 6 | Walt Disney Pictures | false | false |
| 19 | 17 | Terra madre | $14,444 | -26.1% | - | - | - | $192,935 | 4 | BIM Distribuzione | false | false |
| 20 | 13 | The Milk of Sorrow | $13,812 | -50.1% | 12 | -22 | $1,151 | $213,467 | 4 | N/A | false | false |
