| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $3,325,353 | -49.8% | 520 | +5 | $6,394 | $19,632,929 | 2 | 20th Century Fox International | false | false |
| 2 | - | Drag Me to Hell | $3,087,393 | - | 397 | - | $7,776 | $3,087,393 | 1 | Lionsgate | true | false |
| 3 | 2 | Angels & Demons | $1,696,063 | -56.6% | 512 | +6 | $3,312 | $23,225,135 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Star Trek | $1,401,973 | -46.5% | 459 | -15 | $3,054 | $29,186,820 | 4 | Paramount Pictures International | false | false |
| 5 | - | 12 Rounds | $528,886 | - | 300 | - | $1,762 | $528,886 | 1 | 20th Century Fox International | true | false |
| 6 | 5 | Coraline | $455,438 | -37.6% | 432 | -8 | $1,054 | $10,174,676 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Hannah Montana: The Movie | $408,199 | -38% | 449 | - | $909 | $12,312,503 | 5 | Walt Disney Pictures | false | false |
| 8 | 4 | X-Men Origins: Wolverine | $356,037 | -51.3% | 314 | -93 | $1,133 | $25,797,004 | 5 | 20th Century Fox International | false | false |
| 9 | - | Obsessed | $249,784 | - | 149 | - | $1,676 | $249,784 | 1 | Sony Pictures Releasing | true | false |
| 10 | - | Jonas Brothers: The 3D Concert Experience | $189,445 | - | 169 | - | $1,120 | $189,445 | 1 | Walt Disney Pictures | true | false |
| 11 | 8 | Tormented | $100,172 | -77.9% | 217 | -17 | $461 | $1,033,909 | 2 | Warner Bros. | false | false |
| 12 | 7 | Fighting | $97,276 | -79.6% | 168 | -123 | $579 | $3,163,551 | 3 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | Ghosts of Girlfriends Past | $66,005 | -74.6% | 104 | -133 | $634 | $6,596,665 | 5 | Entertainment Film Distributors | false | false |
| 14 | 11 | Synecdoche, New York | $56,914 | -49% | 40 | +1 | $1,422 | $605,397 | 3 | Revolver Entertainment | false | false |
| 15 | 12 | Monsters vs. Aliens | $53,937 | -51.2% | 218 | -114 | $247 | $33,991,428 | 9 | Paramount Pictures International | false | false |
| 16 | - | Fireflies in the Garden 2008 Re-release | $33,707 | - | 27 | - | $1,248 | $33,707 | 1 | The Works UK Distribution | true | false |
| 17 | 15 | In the Loop | $25,078 | -52.8% | 31 | -1 | $808 | $3,311,248 | 7 | Optimum Releasing | false | false |
| 18 | - | Sleep Furiously | $18,906 | - | 9 | - | $2,100 | $18,906 | 1 | New Wave Films | true | false |
| 19 | 17 | Chéri | $11,524 | -58% | 22 | -3 | $523 | $585,995 | 4 | Warner Bros. | false | false |
| 20 | 14 | Awaydays | $7,150 | -88.5% | 22 | -24 | $325 | $112,194 | 2 | Optimum Releasing | false | false |
| 21 | 26 | Slumdog Millionaire | $6,465 | +80.8% | 6 | +3 | $1,077 | $51,237,305 | 21 | Pathé | false | false |
| 22 | 20 | Is Anybody There? | $6,239 | -50.9% | 17 | -1 | $367 | $648,514 | 5 | Optimum Releasing | false | false |
| 23 | 25 | The Young Victoria | $5,658 | +53.3% | 4 | +2 | $1,414 | $7,964,822 | 13 | Momentum Pictures | false | false |
| 24 | - | Fugitive Pieces | $5,407 | - | 6 | - | $901 | $5,407 | 1 | Soda Pictures | true | false |
| 25 | - | Fermat's Room 2009 Re-release | $4,792 | - | 1 | - | $4,792 | $4,792 | 1 | Revolver Entertainment | true | false |
| 26 | 22 | The Damned United | $3,949 | -47.9% | 5 | -3 | $789 | $3,517,041 | 10 | Sony Pictures Releasing | false | false |
| 27 | 23 | The Boat That Rocked | $3,314 | -56.2% | 3 | -2 | $1,104 | $9,892,535 | 9 | Universal Pictures International (UPI) | false | false |
| 28 | 30 | Sounds Like Teen Spirit | $2,971 | +138.3% | 9 | +6 | $330 | $31,608 | 4 | - | false | false |
| 29 | - | The Age of Stupid | $1,741 | - | 4 | - | $435 | $302,619 | 11 | Periscoop Film | false | false |
| 30 | - | A Summer in Genoa | $984 | - | 2 | - | $492 | $199,714 | 10 | - | false | false |
| 31 | 27 | Shifty | $581 | -76.5% | 2 | -2 | $290 | $229,762 | 6 | - | false | false |
| 32 | 29 | Fifty Dead Men Walking | $477 | -61.7% | 2 | -1 | $238 | $621,807 | 8 | - | false | false |
