| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $663,037 | - | 77 | - | $8,610 | $698,359 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Angels & Demons | $425,484 | -11.9% | 98 | - | $4,341 | $3,378,641 | 4 | Sony Pictures Releasing | false | false |
| 3 | 2 | Night at the Museum: Battle of the Smithsonian | $355,929 | -4.6% | 85 | - | $4,187 | $1,594,160 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | 17 Again | $113,079 | +3.9% | 36 | - | $3,141 | $1,017,831 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 5 | 6 | The Girl with the Dragon Tattoo | $81,672 | +7.2% | 41 | -1 | $1,992 | $377,791 | 3 | Benelux Film Distributors | false | false |
| 6 | 4 | X-Men Origins: Wolverine | $78,230 | -24.6% | 70 | -30 | $1,117 | $2,223,157 | 6 | 20th Century Fox International | false | false |
| 7 | 5 | Star Trek | $53,867 | -33.5% | 42 | -1 | $1,282 | $937,520 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | He's Just Not That Into You | $51,756 | +19.5% | 22 | -2 | $2,352 | $1,094,588 | 7 | Paradiso Entertainment | false | false |
| 9 | 13 | Beverly Hills Chihuahua | $50,304 | +131.1% | 39 | -1 | $1,289 | $1,233,045 | 10 | Walt Disney Pictures | false | false |
| 10 | - | Sunshine Cleaning | $42,569 | - | 10 | - | $4,256 | $67,289 | 1 | A-Film Distribution | true | false |
| 11 | 9 | Sister Smile | $39,849 | +16.3% | 33 | - | $1,207 | $517,178 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 12 | 16 | Monsters vs. Aliens | $38,956 | +127.2% | 41 | -15 | $950 | $1,714,890 | 10 | Universal Pictures International (UPI) | false | false |
| 13 | 8 | My Bloody Valentine | $38,620 | -10.3% | 14 | - | $2,758 | $526,444 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 14 | 10 | Knowing | $31,362 | +2.2% | 13 | -4 | $2,412 | $2,641,929 | 10 | Belga Films | false | false |
| 15 | - | Home | $29,466 | - | 12 | - | $2,455 | $29,466 | 1 | Belga Films | true | false |
| 16 | 11 | Fast & Furious | $23,054 | -18.5% | 27 | -6 | $853 | $3,322,090 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | 18 | Slumdog Millionaire | $23,029 | +61.8% | 21 | -2 | $1,096 | $3,763,910 | 21 | Cinéart | false | false |
| 18 | 12 | Bank Error in Your Favour | $22,232 | -16% | 14 | - | $1,588 | $59,163 | 2 | Cinéart | false | false |
| 19 | 14 | Coco Before Chanel | $19,663 | +7.1% | 27 | -2 | $728 | $613,075 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 20 | 15 | The Last House on the Left | $14,080 | -21.4% | 8 | -8 | $1,760 | $366,343 | 7 | Universal Pictures International (UPI) | false | false |
| 21 | 17 | Incognito | $12,504 | -26.4% | 12 | -3 | $1,042 | $299,790 | 6 | Alternative Films | false | false |
| 22 | 19 | Je l'aimais | $10,771 | -18.5% | 11 | -3 | $979 | $150,664 | 5 | N/A | false | false |
| 23 | 23 | S&M Judge | $8,479 | +28.9% | 11 | -1 | $770 | $1,121,303 | 13 | Kinepolis Film Distribution (KFD) | false | false |
| 24 | 32 | Ponyo | $8,256 | +310.7% | 6 | -1 | $1,376 | $113,055 | 9 | Cinéart | false | false |
| 25 | 21 | OSS 117: Lost in Rio | $7,980 | -17.1% | 9 | -3 | $886 | $761,071 | 8 | Belga Films | false | false |
| 26 | 20 | Vengeance | $6,886 | -33.8% | 13 | -3 | $529 | $24,469 | 2 | N/A | false | false |
| 27 | - | Villa Amalia 2009 Re-release | $5,885 | - | 2 | - | $2,942 | $5,885 | 1 | N/A | true | false |
| 28 | 37 | Hotel for Dogs | $5,022 | +382.9% | 3 | -1 | $1,674 | $1,292,617 | 16 | Universal Pictures International (UPI) | false | false |
| 29 | 34 | Bolt | $4,949 | +205.3% | 3 | -1 | $1,649 | $3,271,622 | 17 | Walt Disney Pictures | false | false |
| 30 | 22 | The Boy in the Striped Pajamas | $4,902 | -47.2% | 10 | -1 | $490 | $127,503 | 6 | Walt Disney Pictures | false | false |
| 31 | 29 | The Reader | $3,935 | +61.7% | 9 | - | $437 | $879,171 | 14 | Benelux Film Distributors | false | false |
| 32 | 27 | London River | $3,738 | +24.6% | 10 | - | $373 | $73,176 | 6 | ABC Distribution | false | false |
| 33 | 26 | Duplicity | $3,594 | +17.8% | 2 | - | $1,797 | $952,243 | 11 | Universal Pictures International (UPI) | false | false |
| 34 | - | 35 Shots of Rum | $3,550 | - | 5 | - | $710 | $3,714 | 1 | Cinéart | true | false |
| 35 | 25 | The Boat That Rocked | $3,274 | -21.3% | 3 | -2 | $1,091 | $84,981 | 5 | Universal Pictures International (UPI) | false | false |
| 36 | 28 | Eden Is West | $3,092 | +8.2% | 3 | - | $1,030 | $9,889 | 2 | Alternative Films | false | false |
| 37 | 24 | In the Electric Mist | $2,968 | -40.9% | 5 | - | $593 | $245,561 | 7 | Benelux Film Distributors | false | false |
| 38 | 30 | Tokyo Sonata | $2,964 | +34.6% | 2 | - | $1,482 | $14,077 | 3 | A-Film Distribution | false | false |
| 39 | 33 | Synecdoche, New York | $1,933 | +10.8% | 3 | - | $644 | $16,341 | 4 | Paradiso Entertainment | false | false |
| 40 | - | Twilight | $620 | - | 1 | - | $620 | $3,576,657 | 28 | Belga Films | false | false |
| 41 | 35 | Make It Happen | $573 | -59.5% | 6 | - | $95 | $344,305 | 9 | Benelux Film Distributors | false | false |
| 42 | 36 | Chéri | $456 | -57.1% | 6 | - | $76 | $256,520 | 9 | Benelux Film Distributors | false | false |
