| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $574,906 | -20.2% | 92 | - | $6,248 | $1,646,012 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Angels & Demons | $446,907 | -27.2% | 160 | +1 | $2,793 | $2,389,799 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | The Unborn | $141,949 | -21.8% | 36 | - | $3,943 | $400,207 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | New in Town | $110,691 | - | 31 | - | $3,570 | $110,691 | 1 | Distribution Company | true | false |
| 5 | 5 | Jonas Brothers: The 3D Concert Experience | $88,115 | -3.2% | 14 | +1 | $6,293 | $219,732 | 2 | Walt Disney Pictures | false | false |
| 6 | 6 | The Reader | $62,895 | -24.8% | 31 | -1 | $2,028 | $475,996 | 4 | Pachamama Cine | false | false |
| 7 | 4 | X-Men Origins: Wolverine | $61,254 | -39.3% | 66 | -46 | $928 | $1,696,769 | 5 | 20th Century Fox International | false | false |
| 8 | 9 | Earth | $31,019 | +11.2% | 25 | -1 | $1,240 | $439,938 | 6 | Walt Disney Pictures | false | false |
| 9 | 7 | 17 Again | $30,830 | -41.1% | 47 | - | $655 | $406,868 | 4 | Distribution Company | false | false |
| 10 | 8 | Star Trek | $27,627 | -18.3% | 30 | -7 | $920 | $391,646 | 4 | Paramount Pictures International | false | false |
| 11 | 10 | Duplicity | $25,210 | +0.8% | 30 | +7 | $840 | $568,891 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 13 | Race to Witch Mountain | $21,532 | +0.1% | 41 | -4 | $525 | $959,930 | 8 | Walt Disney Pictures | false | false |
| 13 | 12 | Lorna's Silence | $14,176 | -35.3% | 8 | - | $1,772 | $76,799 | 3 | Distribution Company | false | false |
| 14 | 11 | Fast & Furious | $13,939 | -42.8% | 36 | -7 | $387 | $1,897,268 | 9 | Universal Pictures International (UPI) | false | false |
| 15 | - | Chef's Special 2009 Re-release | $13,250 | - | 13 | - | $1,019 | $13,250 | 1 | Alfa Films | true | false |
| 16 | - | The Artist | $13,233 | - | 5 | - | $2,646 | $13,233 | 1 | Primer Plano Film Group | true | false |
| 17 | 18 | The Class | $11,550 | +50.1% | 15 | +8 | $770 | $297,749 | 7 | Primer Plano Film Group | false | false |
| 18 | 30 | The Merry Widow | $10,854 | +791.1% | 8 | +4 | $1,356 | $144,478 | 7 | Alfa Films | false | false |
| 19 | 16 | Gardens in Autumn 2008 Re-release | $10,468 | +3.1% | 7 | +2 | $1,495 | $69,906 | 5 | IFA | false | false |
| 20 | 15 | The Accidental Husband | $9,279 | -11.8% | 15 | -3 | $618 | $217,944 | 5 | Walt Disney Pictures | false | false |
| 21 | 19 | Monsters vs. Aliens | $7,263 | +1.6% | 11 | -12 | $660 | $1,602,040 | 9 | Paramount Pictures International | false | false |
| 22 | 14 | Esperando la carroza 2: Se acabó la fiesta | $7,142 | -38.4% | 13 | -8 | $549 | $1,308,422 | 9 | Primer Plano Film Group | false | false |
| 23 | 17 | He's Just Not That Into You | $5,558 | -41.1% | 6 | -7 | $926 | $1,071,481 | 13 | Distribution Company | false | false |
| 24 | 25 | Then She Found Me | $5,370 | +153.7% | 10 | +3 | $537 | $74,960 | 5 | Distribution Company | false | false |
| 25 | 23 | Knowing | $5,246 | +20.2% | 15 | +1 | $349 | $1,086,580 | 9 | Alfa Films | false | false |
| 26 | 20 | Days of May | $4,400 | -37.4% | 5 | - | $880 | $14,606 | 2 | Primer Plano Film Group | false | false |
| 27 | 21 | Blood Appears | $3,040 | -45.4% | 2 | -4 | $1,520 | $21,421 | 3 | N/A | false | false |
| 28 | 31 | Live! | $2,725 | +149.3% | 3 | - | $908 | $231,439 | 7 | Distribution Company | false | false |
| 29 | 22 | A Thousand Years of Good Prayers | $2,159 | -58% | 5 | - | $431 | $9,403 | 2 | Primer Plano Film Group | false | false |
| 30 | 28 | Luisa | $1,728 | +34.1% | 5 | +3 | $345 | $12,167 | 4 | Primer Plano Film Group | false | false |
| 31 | 37 | Rumba | $1,714 | +1,228.7% | 6 | +5 | $285 | $67,645 | 9 | Distribution Company | false | false |
| 32 | 24 | Dragonball Evolution | $1,008 | -69.2% | 9 | -20 | $112 | $580,795 | 8 | 20th Century Fox International | false | false |
| 33 | 27 | The Edge of Heaven | $661 | -52.4% | 1 | -3 | $661 | $156,180 | 11 | Alfa Films | false | false |
| 34 | 33 | Slumdog Millionaire | $636 | +33.3% | 3 | - | $212 | $1,554,507 | 16 | Distribution Company | false | false |
| 35 | - | Porotos de soja | $302 | - | 1 | - | $302 | $748 | 2 | N/A | false | false |
| 36 | 32 | Belle toujours 2008 Re-release | $301 | -58.9% | 1 | -1 | $301 | $65,970 | 8 | Impacto Cine | false | false |
| 37 | 29 | The Fish Child | $205 | -83.6% | 2 | -1 | $102 | $152,209 | 8 | Distribution Company | false | false |
| 38 | 26 | Cloud 9 | $189 | -88.5% | 1 | -2 | $189 | $56,116 | 8 | Primer Plano Film Group | false | false |
| 39 | 36 | Pa-ra-da | $148 | -10.3% | 1 | - | $148 | $7,632 | 4 | Primer Plano Film Group | false | false |
| 40 | 38 | Mundo alas | $87 | -30.4% | 1 | -1 | $87 | $34,412 | 10 | Distribution Company | false | false |
| 41 | 40 | Vicky Cristina Barcelona | $81 | -16.5% | 1 | - | $81 | $777,971 | 17 | Pachamama Cine | false | false |
| 42 | 42 | Gomorrah | $59 | +37.2% | 1 | - | $59 | $255,789 | 12 | Alfa Films | false | false |
