| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $226,876 | -48.8% | 102 | - | $2,224 | $889,746 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Night at the Museum: Battle of the Smithsonian | $80,988 | - | 27 | - | $2,999 | $80,988 | 1 | 20th Century Fox International | true | false |
| 3 | - | Ghosts of Girlfriends Past | $22,166 | - | 13 | - | $1,705 | $22,166 | 1 | Warner Bros. | true | false |
| 4 | 2 | Hannah Montana: The Movie | $15,284 | -32.1% | 12 | - | $1,273 | $44,996 | 2 | Walt Disney Pictures | false | false |
| 5 | 3 | X-Men Origins: Wolverine | $7,434 | -61.7% | 14 | -4 | $531 | $241,665 | 4 | 20th Century Fox International | false | false |
| 6 | 4 | The Unborn | $7,050 | -56.2% | 13 | -2 | $542 | $81,975 | 3 | United International Pictures | false | false |
| 7 | 5 | Knowing | $7,014 | -36.3% | 6 | -3 | $1,169 | $52,234 | 3 | N/A | false | false |
| 8 | 6 | Star Trek | $3,215 | -66.9% | 2 | -6 | $1,607 | $47,953 | 3 | United International Pictures | false | false |
| 9 | 7 | Paul Blart: Mall Cop | $2,035 | -73.8% | 5 | -2 | $407 | $231,645 | 7 | Sony Pictures Releasing | false | false |
| 10 | 8 | Doubt | $1,715 | -63.5% | 2 | -4 | $857 | $9,281 | 2 | Walt Disney Pictures | false | false |
| 11 | 13 | Underworld: Rise of the Lycans | $425 | +49.6% | 1 | -1 | $425 | $310,431 | 9 | Sony Pictures Releasing | false | false |
| 12 | 12 | Earth | $185 | -47.7% | 1 | - | $185 | $24,513 | 5 | Walt Disney Pictures | false | false |
| 13 | 10 | Race to Witch Mountain | $141 | -89% | 1 | -3 | $141 | $132,877 | 6 | Walt Disney Pictures | false | false |
| 14 | 9 | 17 Again | $48 | -96.6% | 1 | -3 | $48 | $81,314 | 5 | Warner Bros. | false | false |
