| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum: Battle of the Smithsonian | $420,313 | - | 60 | - | $7,005 | $420,313 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Angels & Demons | $249,708 | -49.9% | 52 | - | $4,802 | $928,233 | 2 | Sony Pictures Releasing | false | false |
| 3 | 3 | Ghosts of Girlfriends Past | $55,164 | -41% | 22 | - | $2,507 | $188,791 | 2 | Warner Bros. | false | false |
| 4 | 2 | Hannah Montana: The Movie | $51,334 | -64.1% | 26 | - | $1,974 | $437,982 | 3 | Walt Disney Pictures | false | false |
| 5 | 4 | Star Trek | $28,703 | -67.9% | 40 | - | $717 | $391,891 | 3 | Paramount Pictures International | false | false |
| 6 | - | The Wrestler | $27,067 | - | 14 | - | $1,933 | $27,067 | 1 | N/A | true | false |
| 7 | - | Funny Games | $26,640 | - | 15 | - | $1,776 | $26,640 | 1 | N/A | true | false |
| 8 | 6 | My Bloody Valentine | $23,784 | -45.7% | 25 | - | $951 | $455,333 | 4 | N/A | false | false |
| 9 | 5 | X-Men Origins: Wolverine | $17,890 | -75.6% | 60 | - | $298 | $856,689 | 4 | 20th Century Fox International | false | false |
| 10 | 23 | Fast & Furious | $15,256 | +3,567.3% | 25 | - | $610 | $648,670 | 8 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Monsters vs. Aliens | $4,961 | -63.5% | 48 | - | $103 | $963,317 | 8 | Paramount Pictures International | false | false |
| 12 | - | The Women | $3,023 | - | 14 | - | $215 | $101,969 | 10 | N/A | false | false |
| 13 | 10 | Flawless | $2,858 | -72.8% | 12 | - | $238 | $69,483 | 3 | N/A | false | false |
| 14 | 7 | 17 Again | $2,665 | -87.9% | 20 | - | $133 | $261,894 | 4 | Warner Bros. | false | false |
| 15 | 8 | Paul Blart: Mall Cop | $2,280 | -83.6% | 4 | -5 | $570 | $383,632 | 5 | Sony Pictures Releasing | false | false |
| 16 | 11 | Unrest 2009 Re-release | $1,780 | -83% | 20 | - | $89 | $321,898 | 6 | N/A | false | false |
| 17 | 12 | Race to Witch Mountain | $1,401 | -86% | 36 | - | $38 | $865,415 | 7 | Walt Disney Pictures | false | false |
| 18 | 14 | Swing Vote | $1,207 | -81.2% | 12 | - | $100 | $61,424 | 8 | N/A | false | false |
| 19 | 18 | The Return | $856 | -73.8% | 10 | - | $85 | $67,396 | 24 | N/A | false | false |
| 20 | 20 | The Counterfeiters | $605 | -80.2% | 7 | - | $86 | $41,025 | 4 | N/A | false | false |
| 21 | 16 | Confessions of a Shopaholic | $603 | -86.8% | 24 | - | $25 | $222,501 | 9 | Walt Disney Pictures | false | false |
| 22 | 13 | The Prize | $367 | -95% | 20 | - | $18 | $110,007 | 4 | N/A | false | false |
| 23 | 19 | Wild Child | $223 | -92.7% | 12 | - | $18 | $69,668 | 13 | Universal Pictures International (UPI) | false | false |
