| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum: Battle of the Smithsonian | $391,362 | - | 73 | - | $5,361 | $391,362 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Angels & Demons | $320,724 | -38.5% | 80 | -1 | $4,009 | $1,046,143 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Star Trek | $193,794 | -40.6% | 53 | +1 | $3,656 | $1,313,753 | 3 | Paramount Pictures International | false | false |
| 4 | - | Knowing | $144,650 | - | 48 | - | $3,013 | $158,609 | 1 | Hoyts Distribution | true | false |
| 5 | 3 | X-Men Origins: Wolverine | $81,509 | -43.7% | 64 | -3 | $1,273 | $1,540,892 | 4 | 20th Century Fox International | false | false |
| 6 | 5 | The Topp Twins: Untouchable Girls | $55,904 | -23.6% | 57 | -1 | $980 | $933,975 | 7 | Rialto Distribution | false | false |
| 7 | 6 | Last Chance Harvey | $49,080 | -25.8% | 47 | -2 | $1,044 | $496,905 | 4 | Hoyts Distribution | false | false |
| 8 | 4 | Ghosts of Girlfriends Past | $37,320 | -52.3% | 42 | - | $888 | $311,074 | 3 | Roadshow Films | false | false |
| 9 | 10 | I've Loved You So Long | $31,560 | +35% | 9 | +1 | $3,506 | $78,712 | 2 | Palace Films | false | false |
| 10 | 7 | Defiance | $30,051 | -39.9% | 31 | -5 | $969 | $374,546 | 4 | Roadshow Films | false | false |
| 11 | 8 | The Reader | $20,465 | -33.9% | 19 | - | $1,077 | $683,948 | 7 | Roadshow Films | false | false |
| 12 | 13 | The Grocer's Son | $19,678 | +22.3% | 12 | - | $1,639 | $157,973 | 5 | Rialto Distribution | false | false |
| 13 | - | A Film with Me in It | $17,705 | - | 19 | - | $931 | $17,705 | 1 | Vendetta Films | true | false |
| 14 | 14 | In Search of Beethoven | $16,754 | +41.5% | 28 | +1 | $598 | $37,529 | 2 | - | false | false |
| 15 | - | Vampire Killers | $15,476 | - | 22 | - | $703 | $15,476 | 1 | Paramount Pictures International | true | false |
| 16 | 12 | Monsters vs. Aliens | $10,118 | -50.8% | 44 | -11 | $229 | $1,710,569 | 8 | Paramount Pictures International | false | false |
| 17 | 9 | Fast & Furious | $9,165 | -66.3% | 25 | -17 | $366 | $1,653,441 | 6 | Paramount Pictures International | false | false |
| 18 | - | Bottle Shock | $9,134 | - | 16 | - | $570 | $9,134 | 1 | Roadshow Films | true | false |
| 19 | 15 | Slumdog Millionaire | $8,237 | -25.9% | 25 | -10 | $329 | $3,090,135 | 16 | Hoyts Distribution | false | false |
| 20 | 11 | 17 Again | $7,171 | -65.1% | 26 | -10 | $275 | $833,566 | 6 | Roadshow Films | false | false |
| 21 | 20 | The Class | $4,571 | -10.9% | 3 | - | $1,523 | $42,096 | 5 | Sony Pictures Releasing | false | false |
| 22 | - | Obsessed | $2,635 | - | 1 | - | $2,635 | $2,635 | 1 | Sony Pictures Releasing | true | false |
| 23 | 21 | Crank: High Voltage | $584 | -81.4% | 1 | - | $584 | $4,834 | 2 | Sony Pictures Releasing | false | false |
| 24 | 23 | Rachel Getting Married | $299 | -78.9% | 1 | -1 | $299 | $12,340 | 2 | Sony Pictures Releasing | false | false |
