| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum: Battle of the Smithsonian | $720,399 | - | 92 | - | $7,830 | $977,535 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Angels & Demons | $613,720 | -29.4% | 159 | -2 | $3,859 | $1,684,816 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | The Unborn | $181,563 | - | 36 | - | $5,043 | $229,544 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | X-Men Origins: Wolverine | $100,847 | -42.1% | 112 | +2 | $900 | $1,614,392 | 4 | 20th Century Fox International | false | false |
| 5 | - | Jonas Brothers: The 3D Concert Experience | $91,064 | - | 13 | - | $7,004 | $114,034 | 1 | Walt Disney Pictures | true | false |
| 6 | 4 | The Reader | $83,635 | -12.5% | 32 | -3 | $2,613 | $399,639 | 3 | Pachamama Cine | false | false |
| 7 | 3 | 17 Again | $52,311 | -48.5% | 47 | - | $1,113 | $369,184 | 3 | Distribution Company | false | false |
| 8 | 5 | Star Trek | $33,802 | -58.2% | 37 | -13 | $913 | $356,302 | 3 | Paramount Pictures International | false | false |
| 9 | 10 | Earth | $27,904 | -15.3% | 26 | +2 | $1,073 | $402,631 | 5 | Walt Disney Pictures | false | false |
| 10 | 9 | Duplicity | $25,009 | -46.2% | 23 | -18 | $1,087 | $539,157 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | Fast & Furious | $24,370 | -53.3% | 43 | -5 | $566 | $1,877,097 | 8 | Universal Pictures International (UPI) | false | false |
| 12 | 12 | Lorna's Silence | $21,909 | -14.5% | 8 | - | $2,738 | $59,328 | 2 | Distribution Company | false | false |
| 13 | 6 | Race to Witch Mountain | $21,507 | -63.7% | 45 | -1 | $477 | $934,904 | 7 | Walt Disney Pictures | false | false |
| 14 | 13 | Esperando la carroza 2: Se acabó la fiesta | $11,603 | -44.8% | 21 | -4 | $552 | $1,299,603 | 8 | Primer Plano Film Group | false | false |
| 15 | 11 | The Accidental Husband | $10,523 | -60.4% | 18 | -13 | $584 | $206,809 | 4 | Walt Disney Pictures | false | false |
| 16 | 18 | Gardens in Autumn 2008 Re-release | $10,153 | +22.7% | 5 | +1 | $2,030 | $58,356 | 4 | IFA | false | false |
| 17 | 14 | He's Just Not That Into You | $9,431 | -51.8% | 13 | -9 | $725 | $1,063,540 | 12 | Distribution Company | false | false |
| 18 | 16 | The Class | $7,696 | -32.4% | 7 | -4 | $1,099 | $285,126 | 6 | Primer Plano Film Group | false | false |
| 19 | 7 | Monsters vs. Aliens | $7,151 | -87.7% | 23 | -19 | $310 | $1,594,778 | 8 | Paramount Pictures International | false | false |
| 20 | - | Days of May | $7,025 | - | 5 | - | $1,405 | $8,014 | 1 | Primer Plano Film Group | true | false |
| 21 | 19 | Blood Appears | $5,566 | -26.1% | 6 | - | $927 | $17,468 | 2 | N/A | false | false |
| 22 | - | A Thousand Years of Good Prayers | $5,138 | - | 5 | - | $1,027 | $6,511 | 1 | Primer Plano Film Group | true | false |
| 23 | 15 | Knowing | $4,366 | -70.5% | 14 | -18 | $311 | $1,080,663 | 8 | Alfa Films | false | false |
| 24 | 17 | Dragonball Evolution | $3,270 | -66.7% | 29 | -15 | $112 | $579,193 | 7 | 20th Century Fox International | false | false |
| 25 | 21 | Then She Found Me | $2,117 | -49.3% | 7 | -2 | $302 | $69,182 | 4 | Distribution Company | false | false |
| 26 | 27 | Cloud 9 | $1,649 | +19.7% | 3 | -1 | $549 | $55,678 | 7 | Primer Plano Film Group | false | false |
| 27 | 30 | The Edge of Heaven | $1,389 | +69.8% | 4 | -1 | $347 | $155,297 | 10 | Alfa Films | false | false |
| 28 | 31 | Luisa | $1,289 | +64.8% | 2 | - | $644 | $10,247 | 3 | Primer Plano Film Group | false | false |
| 29 | 23 | The Fish Child | $1,252 | -48.4% | 3 | -4 | $417 | $151,798 | 7 | Distribution Company | false | false |
| 30 | 24 | The Merry Widow | $1,218 | -47.9% | 4 | -2 | $304 | $133,479 | 6 | Alfa Films | false | false |
| 31 | 20 | Live! | $1,093 | -83.3% | 3 | -12 | $364 | $228,529 | 6 | Distribution Company | false | false |
| 32 | 26 | Belle toujours 2008 Re-release | $732 | -55% | 2 | -2 | $366 | $65,523 | 7 | Impacto Cine | false | false |
| 33 | 28 | Slumdog Millionaire | $477 | -62.9% | 3 | -7 | $159 | $1,553,838 | 15 | Distribution Company | false | false |
| 34 | 29 | Música en espera | $381 | -64.3% | 2 | -10 | $190 | $826,770 | 10 | Distribution Company | false | false |
| 35 | 32 | Gran Torino | $186 | -65.5% | 1 | -3 | $186 | $903,115 | 12 | Warner Bros. | false | false |
| 36 | 25 | Pa-ra-da | $165 | -89.9% | 1 | -3 | $165 | $7,442 | 3 | Primer Plano Film Group | false | false |
| 37 | 41 | Rumba | $129 | +14.2% | 1 | - | $129 | $65,923 | 8 | Distribution Company | false | false |
| 38 | 33 | Mundo alas | $125 | -75.8% | 2 | -1 | $62 | $34,325 | 9 | Distribution Company | false | false |
| 39 | 35 | Bedtime Stories | $108 | -73.2% | 2 | -2 | $54 | $2,096,916 | 16 | Walt Disney Pictures | false | false |
| 40 | 42 | Vicky Cristina Barcelona | $97 | +6.6% | 1 | - | $97 | $777,872 | 16 | Pachamama Cine | false | false |
| 41 | 43 | Coraline | $95 | +763.6% | 2 | - | $47 | $141,818 | 11 | Universal Pictures International (UPI) | false | false |
| 42 | 39 | Gomorrah | $43 | -66.7% | 1 | -1 | $43 | $255,700 | 11 | Alfa Films | false | false |
| 43 | 37 | Bolt | $30 | -87.2% | 1 | -2 | $30 | $2,119,907 | 19 | Walt Disney Pictures | false | false |
