| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $521,377 | - | 81 | - | $6,436 | $521,377 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Star Trek | $326,471 | -34.3% | 52 | +1 | $6,278 | $965,559 | 2 | Paramount Pictures International | false | false |
| 3 | 2 | X-Men Origins: Wolverine | $144,655 | -47.6% | 67 | -5 | $2,159 | $1,337,863 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | Ghosts of Girlfriends Past | $78,193 | -31.1% | 42 | - | $1,861 | $230,112 | 2 | Roadshow Films | false | false |
| 5 | 5 | The Topp Twins: Untouchable Girls | $73,214 | -13% | 58 | +4 | $1,262 | $783,086 | 6 | Rialto Distribution | false | false |
| 6 | 4 | Last Chance Harvey | $66,137 | -41.7% | 49 | +3 | $1,349 | $387,679 | 3 | Hoyts Distribution | false | false |
| 7 | 6 | Defiance | $49,974 | -40.2% | 36 | - | $1,388 | $304,295 | 3 | Roadshow Films | false | false |
| 8 | 7 | The Reader | $30,955 | -39.3% | 19 | - | $1,629 | $613,935 | 6 | Roadshow Films | false | false |
| 9 | 8 | Fast & Furious | $27,172 | -44.5% | 42 | -8 | $646 | $1,543,018 | 5 | Paramount Pictures International | false | false |
| 10 | - | I've Loved You So Long | $23,371 | - | 8 | - | $2,921 | $35,398 | 1 | Palace Films | true | false |
| 11 | 9 | 17 Again | $20,566 | -35.1% | 36 | -7 | $571 | $776,247 | 5 | Roadshow Films | false | false |
| 12 | 10 | Monsters vs. Aliens | $20,546 | -15% | 55 | -10 | $373 | $1,602,979 | 7 | Paramount Pictures International | false | false |
| 13 | 11 | The Grocer's Son | $16,096 | -22.4% | 12 | - | $1,341 | $118,936 | 4 | Rialto Distribution | false | false |
| 14 | - | In Search of Beethoven | $11,842 | - | 27 | - | $438 | $11,842 | 1 | - | true | false |
| 15 | 12 | Slumdog Millionaire | $11,123 | -42.6% | 35 | -9 | $317 | $2,900,720 | 15 | Hoyts Distribution | false | false |
| 16 | 15 | Race to Witch Mountain | $9,555 | -19.8% | 31 | -6 | $308 | $698,823 | 6 | Walt Disney Pictures | false | false |
| 17 | 13 | The Boat That Rocked | $7,604 | -57% | 18 | -10 | $422 | $582,727 | 6 | Paramount Pictures International | false | false |
| 18 | 19 | The Boy in the Striped Pajamas | $7,112 | -2.1% | 15 | -4 | $474 | $343,105 | 11 | Walt Disney Pictures | false | false |
| 19 | 16 | Jonas Brothers: The 3D Concert Experience | $6,981 | -34.2% | 9 | - | $775 | $18,657 | 2 | Walt Disney Pictures | false | false |
| 20 | 18 | The Class | $5,133 | -30.5% | 3 | - | $1,711 | $35,298 | 4 | Sony Pictures Releasing | false | false |
| 21 | - | Crank: High Voltage | $3,140 | - | 1 | - | $3,140 | $3,140 | 1 | Sony Pictures Releasing | true | false |
| 22 | 21 | The Pink Panther 2 | $2,049 | -37.1% | 12 | +1 | $170 | $378,057 | 7 | Sony Pictures Releasing | false | false |
| 23 | - | Rachel Getting Married | $1,417 | - | 2 | - | $708 | $11,334 | 1 | Sony Pictures Releasing | true | false |
| 24 | 14 | The International | $1,274 | -90.9% | 7 | -32 | $182 | $228,394 | 4 | Sony Pictures Releasing | false | false |
