| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $66,208 | - | 10 | - | $6,620 | $94,345 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | 17 Again | $15,133 | -33% | 7 | - | $2,161 | $81,747 | 2 | - | false | false |
| 3 | 5 | Monsters vs. Aliens | $7,332 | +1.6% | 9 | - | $814 | $172,312 | 7 | Universal Pictures International (UPI) | false | false |
| 4 | 2 | Coraline | $6,593 | -42.3% | 2 | - | $3,296 | $22,021 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Observe and Report | $6,368 | - | 5 | - | $1,273 | $6,773 | 1 | - | true | false |
| 6 | 3 | X-Men Origins: Wolverine | $5,518 | -51% | 8 | - | $689 | $47,143 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 4 | Star Trek | $3,597 | -53.9% | 3 | - | $1,199 | $14,984 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Fast & Furious | $2,078 | -51.4% | 6 | -2 | $346 | $355,963 | 7 | Universal Pictures International (UPI) | false | false |
| 9 | 9 | I Love You, Man | $1,588 | -49.7% | 5 | -1 | $317 | $30,087 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 6 | My Bloody Valentine | $1,439 | -79.7% | 6 | - | $239 | $106,147 | 4 | ACME | false | false |
| 11 | 10 | Newsmakers | $1,211 | -46.4% | 3 | - | $403 | $5,078 | 2 | N/A | false | false |
| 12 | 13 | Knowing | $925 | -37.9% | 1 | - | $925 | $76,205 | 6 | ACME | false | false |
| 13 | - | Push | $916 | - | 2 | - | $458 | $3,879 | - | ACME | - | false |
| 14 | 8 | Taken | $821 | -77.5% | 6 | - | $136 | $30,396 | 4 | ACME | false | false |
| 15 | 14 | Confessions of a Shopaholic | $667 | -51.1% | 4 | -1 | $166 | $76,521 | 6 | Universal Pictures International (UPI) | false | false |
| 16 | 11 | Crank: High Voltage | $456 | -78.7% | 5 | - | $91 | $92,134 | 5 | ACME | false | false |
| 17 | 20 | The Class | $315 | +65.8% | 2 | - | $157 | $22,491 | 5 | N/A | false | false |
| 18 | - | Marley & Me | $310 | - | 1 | - | $310 | $133,887 | 10 | Universal Pictures International (UPI) | false | false |
| 19 | 23 | Bolt | $267 | +853.6% | 2 | +1 | $133 | $315,717 | 12 | Universal Pictures International (UPI) | false | false |
| 20 | - | Slumdog Millionaire | $244 | - | 1 | - | $244 | $286,818 | 14 | ACME | false | false |
| 21 | 15 | Race to Witch Mountain | $201 | -75.8% | 1 | -4 | $201 | $32,130 | 5 | Universal Pictures International (UPI) | false | false |
| 22 | 19 | Gran Torino | $92 | -56.8% | 3 | - | $30 | $38,479 | 8 | - | false | false |
| 23 | - | The Crimson Wing: Mystery of the Flamingos | $49 | - | 1 | - | $49 | $21,776 | 10 | Universal Pictures International (UPI) | false | false |
| 24 | 18 | Involuntary | $44 | -82% | 1 | - | $44 | $5,392 | 7 | N/A | false | false |
| 25 | 16 | Hotel for Dogs | $39 | -92.4% | 1 | -3 | $39 | $47,848 | 9 | Universal Pictures International (UPI) | false | false |
| 26 | 21 | Duplicity | $14 | -85.9% | 1 | - | $14 | $48,886 | 9 | Universal Pictures International (UPI) | false | false |
