| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $3,893,256 | - | 434 | - | $8,970 | $3,939,599 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Star Trek | $2,034,078 | -43.1% | 317 | - | $6,416 | $6,627,544 | 2 | Paramount Pictures International | false | false |
| 3 | 2 | X-Men Origins: Wolverine | $1,198,438 | -46.7% | 326 | -88 | $3,676 | $11,503,386 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | Ghosts of Girlfriends Past | $930,818 | -32.7% | 219 | - | $4,250 | $2,746,069 | 2 | Roadshow Films | false | false |
| 5 | - | Observe and Report | $340,140 | - | 130 | - | $2,616 | $340,140 | 1 | Warner Bros. | true | false |
| 6 | 4 | Defiance | $297,168 | -41.1% | 174 | - | $1,707 | $2,073,279 | 3 | Roadshow Films | false | false |
| 7 | 5 | Fast & Furious | $206,924 | -52.4% | 181 | -122 | $1,143 | $12,552,341 | 6 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | The Boy in the Striped Pajamas | $187,752 | -33.6% | 120 | - | $1,564 | $2,098,481 | 4 | Walt Disney Pictures | false | false |
| 9 | 9 | Samson & Delilah | $155,787 | +1.8% | 32 | +20 | $4,868 | $382,065 | 2 | Paramount Pictures International | false | false |
| 10 | 7 | 17 Again | $114,472 | -45.7% | 137 | -43 | $835 | $9,322,169 | 6 | Roadshow Films | false | false |
| 11 | - | Jonas Brothers: The 3D Concert Experience | $105,369 | - | 47 | - | $2,241 | $105,369 | 1 | Walt Disney Pictures | true | false |
| 12 | 8 | Monsters vs. Aliens | $84,657 | -52.9% | 125 | -74 | $677 | $15,216,463 | 7 | Paramount Pictures International | false | false |
| 13 | - | Gomorrah | $73,229 | - | 15 | - | $4,881 | $78,890 | 1 | Madman Entertainment | true | false |
| 14 | 10 | The Boat That Rocked | $56,213 | -60.7% | 73 | -59 | $770 | $4,251,228 | 6 | Universal Pictures International (UPI) | false | false |
| 15 | 12 | Mary and Max | $44,542 | -24.7% | 40 | -10 | $1,113 | $909,352 | 6 | Icon Film Distribution | false | false |
| 16 | 14 | Elegy | $33,909 | -33.3% | 37 | -3 | $916 | $740,624 | 6 | Hopscotch Films | false | false |
| 17 | 15 | The Baader Meinhof Complex | $32,405 | -32.6% | 20 | - | $1,620 | $119,912 | 2 | Icon Film Distribution | false | false |
| 18 | 17 | Tulpan | $31,912 | -30.2% | 25 | +3 | $1,276 | $329,753 | 4 | Palace Films | false | false |
| 19 | 18 | Easy Virtue | $28,436 | -34.8% | 51 | -14 | $557 | $1,996,738 | 10 | Hopscotch Films | false | false |
| 20 | 20 | Synecdoche, New York | $24,393 | -22.6% | 5 | - | $4,878 | $67,856 | 2 | Roadshow Films | false | false |
| 21 | 11 | Fired Up! | $15,569 | -79.7% | 25 | -76 | $622 | $941,069 | 4 | Sony Pictures Releasing | false | false |
| 22 | 21 | Paris 36 | $13,807 | -46.9% | 12 | - | $1,150 | $145,063 | 3 | Sony Pictures Releasing | false | false |
| 23 | 23 | Paul Blart: Mall Cop | $5,502 | -2.9% | 15 | -6 | $366 | $3,733,141 | 9 | Sony Pictures Releasing | false | false |
| 24 | - | Quiet Chaos | $4,382 | - | 11 | - | $398 | $4,382 | 1 | Sharmill Films | true | false |
| 25 | 22 | The Pink Panther 2 | $2,309 | -74.1% | 9 | -16 | $256 | $2,085,678 | 7 | Sony Pictures Releasing | false | false |
