| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $869,349 | - | 161 | - | $5,399 | $869,349 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | X-Men Origins: Wolverine | $174,200 | -46.9% | 110 | +21 | $1,583 | $1,421,935 | 3 | 20th Century Fox International | false | false |
| 3 | 3 | 17 Again | $101,639 | -31.9% | 47 | - | $2,162 | $279,730 | 2 | Distribution Company | false | false |
| 4 | 4 | The Reader | $95,599 | -31% | 35 | +2 | $2,731 | $271,983 | 2 | Pachamama Cine | false | false |
| 5 | 2 | Star Trek | $80,868 | -49.9% | 50 | - | $1,617 | $285,511 | 2 | Paramount Pictures International | false | false |
| 6 | 6 | Race to Witch Mountain | $59,201 | -17.7% | 46 | - | $1,286 | $892,714 | 6 | Walt Disney Pictures | false | false |
| 7 | 8 | Monsters vs. Aliens | $58,008 | -4.8% | 42 | -18 | $1,381 | $1,573,073 | 7 | Paramount Pictures International | false | false |
| 8 | 5 | Fast & Furious | $52,184 | -28.9% | 48 | +1 | $1,087 | $1,827,709 | 7 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Duplicity | $46,524 | -34.7% | 41 | +2 | $1,134 | $497,687 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Earth | $32,957 | -31.4% | 24 | -4 | $1,373 | $354,115 | 4 | Walt Disney Pictures | false | false |
| 11 | 10 | The Accidental Husband | $26,577 | -43.6% | 31 | -4 | $857 | $186,730 | 3 | Walt Disney Pictures | false | false |
| 12 | - | Lorna's Silence | $25,635 | - | 8 | - | $3,204 | $25,635 | 1 | Distribution Company | true | false |
| 13 | 12 | Esperando la carroza 2: Se acabó la fiesta | $21,025 | -46% | 25 | -38 | $841 | $1,276,914 | 7 | Primer Plano Film Group | false | false |
| 14 | 13 | He's Just Not That Into You | $19,582 | -36.6% | 22 | -1 | $890 | $1,047,793 | 11 | Distribution Company | false | false |
| 15 | 11 | Knowing | $14,793 | -65.6% | 32 | -17 | $462 | $1,069,214 | 7 | Alfa Films | false | false |
| 16 | 14 | The Class | $11,383 | -55.8% | 11 | -8 | $1,034 | $271,901 | 5 | Primer Plano Film Group | false | false |
| 17 | 16 | Dragonball Evolution | $9,827 | -35.1% | 44 | -4 | $223 | $571,492 | 6 | 20th Century Fox International | false | false |
| 18 | 19 | Gardens in Autumn 2008 Re-release | $8,274 | -21.1% | 4 | - | $2,068 | $44,072 | 3 | IFA | false | false |
| 19 | - | Blood Appears | $7,529 | - | 6 | - | $1,254 | $7,529 | 1 | N/A | true | false |
| 20 | 15 | Live! | $6,551 | -73.6% | 15 | -8 | $436 | $224,650 | 5 | Distribution Company | false | false |
| 21 | 17 | Then She Found Me | $4,179 | -68.5% | 9 | -11 | $464 | $64,882 | 3 | Distribution Company | false | false |
| 22 | 18 | Big Stan | $2,502 | -79.2% | 5 | -13 | $500 | $102,086 | 4 | Pachamama Cine | false | false |
| 23 | 21 | The Fish Child | $2,427 | -65.8% | 7 | -3 | $346 | $149,203 | 6 | Distribution Company | false | false |
| 24 | 22 | The Merry Widow | $2,340 | -66.4% | 6 | -2 | $390 | $131,257 | 5 | Alfa Films | false | false |
| 25 | 26 | Pa-ra-da | $1,639 | -55.2% | 4 | -1 | $409 | $6,599 | 2 | Primer Plano Film Group | false | false |
| 26 | 31 | Belle toujours 2008 Re-release | $1,625 | +1.4% | 4 | +3 | $406 | $63,809 | 6 | Impacto Cine | false | false |
| 27 | 29 | Cloud 9 | $1,378 | -45.9% | 4 | - | $344 | $53,057 | 6 | Primer Plano Film Group | false | false |
| 28 | 20 | Slumdog Millionaire | $1,284 | -82% | 10 | -12 | $128 | $1,552,654 | 14 | Distribution Company | false | false |
| 29 | 24 | Música en espera | $1,066 | -81.1% | 12 | -17 | $88 | $825,349 | 9 | Distribution Company | false | false |
| 30 | 30 | The Edge of Heaven | $818 | -61.1% | 5 | +1 | $163 | $153,063 | 9 | Alfa Films | false | false |
| 31 | 23 | Luisa | $782 | -86.2% | 2 | -7 | $391 | $8,167 | 2 | Primer Plano Film Group | false | false |
| 32 | 32 | Gran Torino | $539 | -63% | 4 | -1 | $134 | $902,740 | 11 | Warner Bros. | false | false |
| 33 | 41 | Mundo alas | $517 | +81.4% | 3 | +1 | $172 | $34,073 | 8 | Distribution Company | false | false |
| 34 | 27 | Fireflies in the Garden 2008 Re-release | $406 | -88.7% | 1 | -6 | $406 | $75,443 | 8 | - | false | false |
| 35 | 35 | Bedtime Stories | $403 | -45.6% | 4 | -2 | $100 | $2,096,569 | 15 | Walt Disney Pictures | false | false |
| 36 | 25 | Hotel for Dogs | $331 | -91.7% | 4 | -7 | $82 | $633,029 | 13 | Paramount Pictures International | false | false |
| 37 | 39 | Bolt | $235 | -48.6% | 3 | - | $78 | $2,119,850 | 18 | Walt Disney Pictures | false | false |
| 38 | 37 | Manuel de Falla, músico de dos mundos | $226 | -60.7% | 2 | - | $113 | $6,045 | 3 | Primer Plano Film Group | false | false |
| 39 | 40 | Gomorrah | $129 | -61.3% | 2 | +1 | $64 | $255,570 | 10 | Alfa Films | false | false |
| 40 | 43 | Transporter 3 | $121 | -4% | 1 | - | $121 | $386,925 | 10 | - | false | false |
| 41 | 33 | Rumba | $113 | -89.6% | 1 | -1 | $113 | $65,720 | 7 | Distribution Company | false | false |
| 42 | 44 | Vicky Cristina Barcelona | $91 | -19.5% | 1 | - | $91 | $777,709 | 15 | Pachamama Cine | false | false |
| 43 | 38 | Coraline | $11 | -97.9% | 2 | -1 | $5 | $141,671 | 10 | Universal Pictures International (UPI) | false | false |
