| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | X-Men Origins: Wolverine | $2,718,465 | - | 407 | - | $6,679 | $3,658,682 | 1 | 20th Century Fox International | true | false |
| 2 | - | Hannah Montana: The Movie | $1,439,044 | - | 346 | - | $4,159 | $1,631,745 | 1 | Walt Disney Pictures | true | false |
| 3 | - | State of Play | $1,144,067 | - | 301 | - | $3,800 | $1,292,089 | 1 | United International Pictures | true | false |
| 4 | 1 | Fast & Furious | $783,355 | -62.9% | 341 | -81 | $2,297 | $10,300,050 | 3 | United International Pictures | false | false |
| 5 | 2 | Questione di cuore | $443,005 | -45.7% | 217 | -47 | $2,041 | $2,826,075 | 3 | 01 Distribution | false | false |
| 6 | 5 | Generazione mille euro | $382,672 | -45.9% | 233 | -34 | $1,642 | $1,372,902 | 2 | 01 Distribution | false | false |
| 7 | 3 | Monsters vs. Aliens | $349,823 | -56.5% | 171 | -31 | $2,045 | $9,500,655 | 5 | United International Pictures | false | false |
| 8 | - | Che: Part Two | $308,544 | - | 179 | - | $1,723 | $353,058 | 1 | BIM Distribuzione | true | false |
| 9 | 4 | Death Defying Acts | $290,909 | -59.9% | 180 | -7 | $1,616 | $1,241,833 | 2 | Eagle Pictures | false | false |
| 10 | 7 | Earth | $173,178 | -50.3% | 87 | +7 | $1,990 | $702,982 | 2 | Walt Disney Pictures | false | false |
| 11 | 6 | Marley & Me | $149,264 | -69.3% | 203 | +3 | $735 | $6,503,267 | 5 | 20th Century Fox International | false | false |
| 12 | 13 | Gran Torino | $147,256 | -42.1% | 59 | -29 | $2,495 | $11,448,216 | 8 | Warner Bros. | false | false |
| 13 | - | Diary of a Nymphomaniac | $131,189 | - | 82 | - | $1,599 | $154,507 | 1 | Sony Pictures Releasing | true | false |
| 14 | 11 | The Tale of Despereaux | $129,641 | -55.5% | 103 | +3 | $1,258 | $474,979 | 2 | United International Pictures | false | false |
| 15 | 15 | Sbirri | $113,041 | -51.8% | 64 | -40 | $1,766 | $2,274,670 | 4 | Medusa Distribuzione | false | false |
| 16 | 12 | The Friends at the Margherita Cafe | $96,364 | -66% | 56 | -95 | $1,720 | $3,750,724 | 5 | 01 Distribution | false | false |
| 17 | - | Elegy | $95,027 | - | 33 | - | $2,879 | $106,394 | 1 | 01 Distribution | true | false |
| 18 | 9 | Duplicity | $83,403 | -73.9% | 74 | -66 | $1,127 | $2,847,062 | 4 | United International Pictures | false | false |
| 19 | 10 | Che: Part One | $76,229 | -74.8% | 60 | -123 | $1,270 | $2,559,128 | 4 | BIM Distribuzione | false | false |
| 20 | 17 | Chef's Special 2009 Re-release | $69,491 | -56.3% | 53 | -44 | $1,311 | $286,879 | 2 | N/A | false | false |
| 21 | - | When a Man Comes Home 2009 Re-release | $63,384 | - | 32 | - | $1,980 | $70,331 | 1 | Teodora Film | true | false |
| 22 | 14 | RocknRolla | $41,584 | -83.1% | 65 | -73 | $639 | $386,404 | 2 | Walt Disney Pictures | false | false |
| 23 | 8 | What Just Happened | $40,638 | -87.9% | 41 | -171 | $991 | $1,350,455 | 3 | Medusa Distribuzione | false | false |
| 24 | - | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $25,874 | - | 7 | - | $3,696 | $72,993 | 46 | Walt Disney Pictures | false | false |
| 25 | 19 | Louise hires a contract killer | $25,349 | -48.4% | 15 | -16 | $1,689 | $590,742 | 5 | Fandango | false | false |
| 26 | 20 | Two Lovers | $25,115 | -48.5% | 12 | -12 | $2,092 | $1,069,119 | 6 | BIM Distribuzione | false | false |
| 27 | - | Tulpan | $17,553 | - | 15 | - | $1,170 | $80,943 | 2 | BIM Distribuzione | false | false |
| 28 | 16 | Franklyn | $13,171 | -91.8% | 24 | -101 | $548 | $675,657 | 3 | Sony Pictures Releasing | false | false |
| 29 | - | La matassa | $12,118 | - | 7 | - | $1,731 | $10,007,765 | 8 | Medusa Distribuzione | false | false |
| 30 | - | Slumdog Millionaire | $11,670 | - | 8 | - | $1,458 | $8,039,633 | 22 | Lucky Red | false | false |
| 31 | - | Tutta colpa di Giuda | $11,205 | - | 11 | - | $1,018 | $320,777 | 4 | Warner Bros. | false | false |
| 32 | - | The Reader | $8,489 | - | 6 | - | $1,414 | $3,280,318 | 11 | 01 Distribution | false | false |
| 33 | 18 | Dragonball Evolution | $7,898 | -93% | 15 | -140 | $526 | $2,661,061 | 4 | 20th Century Fox International | false | false |
| 34 | - | Ponyo | $7,010 | - | 13 | - | $539 | $1,013,560 | 7 | Lucky Red | false | false |
