| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | X-Men Origins: Wolverine | $9,933,585 | - | 488 | - | $20,355 | $9,933,585 | 1 | 20th Century Fox International | true | false |
| 2 | - | Hannah Montana: The Movie | $3,029,249 | - | 415 | - | $7,299 | $3,029,249 | 1 | Walt Disney Pictures | true | false |
| 3 | 1 | State of Play | $1,464,189 | -34.2% | 395 | -3 | $3,706 | $4,880,433 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | Ghosts of Girlfriends Past | $1,457,119 | - | 382 | - | $3,814 | $1,457,119 | 1 | Entertainment Film Distributors | true | false |
| 5 | 4 | 17 Again | $797,816 | -47.1% | 413 | -12 | $1,931 | $15,091,011 | 4 | Entertainment Film Distributors | false | false |
| 6 | 2 | Monsters vs. Aliens | $790,026 | -50.2% | 456 | -37 | $1,732 | $29,207,151 | 5 | Paramount Pictures International | false | false |
| 7 | 3 | Fast & Furious | $679,582 | -56.1% | 408 | -22 | $1,665 | $19,246,249 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | I Love You, Man | $534,840 | -48.6% | 303 | -36 | $1,765 | $4,820,015 | 3 | Paramount Pictures International | false | false |
| 9 | 6 | In the Loop | $320,142 | -37.6% | 126 | -25 | $2,540 | $2,216,038 | 3 | Optimum Releasing | false | false |
| 10 | 7 | The Uninvited | $258,034 | -48.9% | 202 | -17 | $1,277 | $1,103,049 | 2 | Paramount Pictures International | false | false |
| 11 | - | Is Anybody There? | $183,947 | - | 96 | - | $1,916 | $183,947 | 1 | Optimum Releasing | true | false |
| 12 | 8 | Observe and Report | $113,201 | -76.4% | 182 | -81 | $621 | $841,638 | 2 | Warner Bros. | false | false |
| 13 | 10 | The Boat That Rocked | $103,844 | -71.7% | 107 | -218 | $970 | $8,947,195 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 9 | Race to Witch Mountain | $100,721 | -72.6% | 309 | -92 | $325 | $3,512,259 | 4 | Walt Disney Pictures | false | false |
| 15 | 14 | Let the Right One In | $74,091 | -47.4% | 58 | -36 | $1,277 | $1,309,868 | 4 | Momentum Pictures | false | false |
| 16 | 11 | Crank: High Voltage | $63,268 | -80.2% | 105 | -201 | $602 | $1,754,743 | 3 | Lionsgate | false | false |
| 17 | 12 | Knowing | $52,121 | -74.4% | 65 | -140 | $801 | $10,036,936 | 6 | Entertainment One | false | false |
| 18 | 13 | Marley & Me | $40,486 | -78.1% | 99 | -198 | $408 | $22,683,300 | 8 | 20th Century Fox International | false | false |
| 19 | 22 | Encounters at the End of the World | $29,802 | -33.2% | 13 | - | $2,292 | $105,980 | 2 | Revolver Entertainment | false | false |
| 20 | 16 | Paul Blart: Mall Cop | $26,416 | -71.6% | 84 | -114 | $314 | $7,978,909 | 7 | Sony Pictures Releasing | false | false |
| 21 | 15 | The Haunting in Connecticut | $26,104 | -75.6% | 40 | -111 | $652 | $6,191,957 | 6 | Entertainment Film Distributors | false | false |
| 22 | 17 | Shifty | $23,732 | -73.8% | 37 | -14 | $641 | $168,509 | 2 | - | false | false |
| 23 | 20 | The Damned United | $23,679 | -52.8% | 43 | -52 | $550 | $3,156,465 | 6 | Sony Pictures Releasing | false | false |
| 24 | 19 | Gran Torino | $21,900 | -56.3% | 28 | -33 | $782 | $12,307,757 | 11 | Warner Bros. | false | false |
| 25 | 25 | Watchmen | $19,349 | -20.2% | 9 | -4 | $2,149 | $13,278,004 | 9 | Paramount Pictures International | false | false |
| 26 | 21 | Fifty Dead Men Walking | $18,605 | -59.6% | 29 | -16 | $641 | $524,199 | 4 | - | false | false |
| 27 | 24 | Slumdog Millionaire | $18,202 | -30.3% | 16 | -15 | $1,137 | $47,147,017 | 17 | Pathé | false | false |
| 28 | 28 | The Young Victoria | $13,606 | -26% | 15 | -8 | $907 | $7,249,953 | 9 | Momentum Pictures | false | false |
| 29 | 31 | Mini Punjab | $10,354 | -20.8% | 5 | -2 | $2,070 | $63,902 | 3 | - | false | false |
| 30 | - | Helen | $8,551 | - | 6 | - | $1,425 | $8,551 | 1 | New Wave Films | true | false |
| 31 | 23 | The Secret of Moonacre | $8,308 | -76.8% | 82 | -83 | $101 | $1,407,038 | 13 | Warner Bros. | false | false |
| 32 | 29 | Duplicity | $5,546 | -63.5% | 7 | -18 | $792 | $4,260,654 | 7 | Universal Pictures International (UPI) | false | false |
| 33 | 32 | Hotel for Dogs | $4,330 | -59.9% | 29 | -16 | $149 | $10,531,597 | 12 | Paramount Pictures International | false | false |
| 34 | 47 | From Russia with Love 2009 Re-release | $3,874 | -0.8% | 1 | - | $3,874 | $11,281 | 2 | Park Circus | false | false |
| 35 | 39 | Waveriders | $3,154 | -45% | 8 | -1 | $394 | $142,878 | 5 | Element Films | false | false |
| 36 | 43 | The Age of Stupid | $2,625 | -40% | 6 | +1 | $437 | $261,404 | 7 | Periscoop Film | false | false |
| 37 | 34 | Good | $2,176 | -77.6% | 5 | -7 | $435 | $72,656 | 3 | Lionsgate | false | false |
| 38 | 33 | Bolt | $1,944 | -81.5% | 13 | -18 | $149 | $26,755,584 | 12 | Walt Disney Pictures | false | false |
| 39 | 52 | A Summer in Genoa | $907 | -64.9% | 1 | -6 | $907 | $174,992 | 6 | - | false | false |
| 40 | - | Funuke: Show Some Love, You Losers! | $713 | - | 1 | - | $713 | $713 | 1 | Third Window Films | true | false |
