| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Fast & Furious | $435,849 | -60.2% | 425 | -25 | $1,025 | $11,888,097 | 4 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | Monsters vs. Aliens | $321,920 | -68.6% | 509 | +65 | $632 | $9,537,477 | 4 | Paramount Pictures International | false | false |
| 3 | 3 | The Haunting in Connecticut | $311,451 | -49.3% | 299 | -1 | $1,041 | $1,265,025 | 2 | Gussi Films | false | false |
| 4 | 6 | Amar a morir | $213,293 | -40.4% | 246 | -70 | $867 | $1,861,290 | 3 | Gussi Films | false | false |
| 5 | 4 | Knowing | $210,252 | -44.6% | 222 | -62 | $947 | $3,850,046 | 5 | Corazón Films | false | false |
| 6 | 7 | Race to Witch Mountain | $203,126 | -23% | 290 | +47 | $700 | $3,125,497 | 5 | Walt Disney Pictures | false | false |
| 7 | - | Igor | $137,559 | - | 250 | - | $550 | $138,108 | 1 | Videocine | true | false |
| 8 | 12 | Slumdog Millionaire | $125,580 | -25.5% | 126 | - | $996 | $5,751,578 | 10 | Gussi Films | false | false |
| 9 | 11 | Gran Torino | $119,548 | -34% | 134 | -5 | $892 | $1,596,651 | 5 | Warner Bros. | false | false |
| 10 | - | I Love You, Man | $105,821 | - | 201 | - | $526 | $105,821 | 1 | Paramount Pictures International | true | false |
| 11 | 5 | Dragonball Evolution | $88,717 | -75.3% | 288 | -109 | $308 | $2,202,614 | 3 | 20th Century Fox International | false | false |
| 12 | 13 | The Accidental Husband | $87,294 | -16.3% | 136 | +34 | $641 | $1,051,138 | 4 | Walt Disney Pictures | false | false |
| 13 | 8 | Duplicity | $68,768 | -73.3% | 100 | -132 | $687 | $1,311,211 | 3 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | El libro de piedra | $63,449 | -69.2% | 153 | -1 | $414 | $376,740 | 2 | N/A | false | false |
| 15 | 17 | The Reader | $57,802 | -16.2% | 77 | +28 | $750 | $705,973 | 4 | Gussi Films | false | false |
| 16 | 16 | The Unborn | $57,715 | -32.3% | 81 | -21 | $712 | $4,919,067 | 7 | Universal Pictures International (UPI) | false | false |
| 17 | 9 | Another Egg and Chicken Movie | $55,428 | -75.8% | 227 | -133 | $244 | $8,113,411 | 6 | Videocine | false | false |
| 18 | 19 | The International | $49,729 | -17.5% | 80 | -12 | $621 | $796,618 | 6 | Sony Pictures Releasing | false | false |
| 19 | 18 | Paul Blart: Mall Cop | $37,544 | -44% | 51 | -30 | $736 | $2,163,232 | 7 | Sony Pictures Releasing | false | false |
| 20 | 20 | Transporter 3 | $36,057 | -8% | 58 | - | $621 | $707,060 | 10 | Zima Entertainment | false | false |
| 21 | 21 | He's Just Not That Into You | $29,127 | +15.8% | 29 | +4 | $1,004 | $1,950,152 | 8 | Gussi Films | false | false |
| 22 | - | Surveillance | $21,929 | - | 108 | - | $203 | $21,929 | 1 | N/A | true | false |
| 23 | 25 | My Sassy Girl | $21,423 | +31.7% | 41 | +9 | $522 | $459,646 | 9 | Videocine | false | false |
| 24 | 32 | Milk | $18,684 | +363.9% | 35 | +27 | $533 | $561,611 | 8 | Universal Pictures International (UPI) | false | false |
| 25 | 28 | Borderland | $17,517 | +210.9% | 59 | +26 | $296 | $140,522 | 3 | Videocine | false | false |
| 26 | 30 | Elegy | $17,243 | +262.1% | 31 | +21 | $556 | $188,451 | 7 | Corazón Films | false | false |
| 27 | 15 | Insignificant Things | $12,719 | -85.6% | 98 | -2 | $129 | $154,063 | 2 | Warner Bros. | false | false |
| 28 | 26 | The Wrestler | $11,637 | -25.7% | 22 | +2 | $528 | $570,671 | 9 | Corazón Films | false | false |
| 29 | - | The Children of Huang Shi | $11,020 | - | 30 | - | $367 | $11,020 | 1 | Gussi Films | true | false |
| 30 | 14 | 12 Rounds | $10,759 | -88.3% | 70 | -10 | $153 | $153,899 | 2 | 20th Century Fox International | false | false |
| 31 | 36 | In Bruges | $9,802 | +413.5% | 22 | +13 | $445 | $90,762 | 6 | Corazón Films | false | false |
| 32 | - | Paraiso Travel | $8,871 | - | 52 | - | $170 | $8,871 | 1 | N/A | true | false |
| 33 | 23 | Changeling | $8,374 | -55.7% | 21 | -7 | $398 | $1,893,315 | 9 | Universal Pictures International (UPI) | false | false |
| 34 | 24 | The Secret Life of Bees | $7,762 | -52.6% | 21 | -14 | $369 | $136,773 | 7 | 20th Century Fox International | false | false |
| 35 | 22 | Cherry Blossoms | $3,345 | -85.3% | 13 | -1 | $257 | $37,723 | 2 | N/A | false | false |
| 36 | 31 | Underworld: Rise of the Lycans | $2,690 | -33.6% | 5 | -2 | $538 | $3,840,284 | 12 | Sony Pictures Releasing | false | false |
| 37 | 33 | The Pink Panther 2 | $2,188 | -38.5% | 4 | -1 | $547 | $2,177,035 | 9 | Sony Pictures Releasing | false | false |
| 38 | 29 | Dark Matter | $1,801 | -65.9% | 5 | -9 | $360 | $27,211 | 5 | David Distribucion | false | false |
| 39 | 37 | Jonas Brothers: The 3D Concert Experience | $1,495 | -12.9% | 12 | +1 | $124 | $1,035,798 | 8 | Walt Disney Pictures | false | false |
| 40 | 39 | Desierto adentro | $1,359 | +296.2% | 8 | +7 | $169 | $44,244 | 7 | Gussi Films | false | false |
| 41 | 34 | Fierce People | $861 | -74.7% | 4 | -13 | $215 | $73,889 | 8 | Videocine | false | false |
| 42 | 41 | Watchmen | $518 | +137.6% | 2 | +1 | $259 | $2,295,796 | 8 | Paramount Pictures International | false | false |
| 43 | 40 | Standard Operating Procedure | $404 | +66.9% | 3 | - | $134 | $7,802 | 4 | N/A | false | false |
| 44 | 27 | Rachel Getting Married | $396 | -94.1% | 3 | -4 | $132 | $90,594 | 6 | Sony Pictures Releasing | false | false |
