| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Fast & Furious | $1,094,532 | -43.7% | 450 | -204 | $2,432 | $10,909,834 | 3 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | Monsters vs. Aliens | $1,025,205 | -32.8% | 444 | -309 | $2,309 | $8,900,727 | 3 | Paramount Pictures International | false | false |
| 3 | - | The Haunting in Connecticut | $614,139 | - | 300 | - | $2,047 | $614,139 | 1 | Gussi Films | true | false |
| 4 | 7 | Knowing | $379,392 | -1.8% | 284 | +8 | $1,335 | $3,419,943 | 4 | Corazón Films | false | false |
| 5 | 3 | Dragonball Evolution | $359,183 | -54.2% | 397 | -5 | $904 | $1,980,353 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | Amar a morir | $358,068 | -19.7% | 316 | -6 | $1,133 | $1,369,977 | 2 | Gussi Films | false | false |
| 7 | 8 | Race to Witch Mountain | $263,793 | -23.3% | 243 | -5 | $1,085 | $2,837,307 | 4 | Walt Disney Pictures | false | false |
| 8 | 5 | Duplicity | $258,037 | -41% | 232 | -26 | $1,112 | $1,109,100 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Another Egg and Chicken Movie | $229,083 | -46.7% | 360 | -62 | $636 | $7,987,106 | 5 | Videocine | false | false |
| 10 | - | El libro de piedra | $205,983 | - | 154 | - | $1,337 | $205,983 | 1 | N/A | true | false |
| 11 | 9 | Gran Torino | $181,167 | +30.1% | 139 | +30 | $1,303 | $1,366,847 | 4 | Warner Bros. | false | false |
| 12 | 11 | Slumdog Millionaire | $168,569 | +43.5% | 126 | +35 | $1,337 | $5,516,541 | 9 | Gussi Films | false | false |
| 13 | 10 | The Accidental Husband | $104,329 | -20.4% | 102 | -80 | $1,022 | $906,426 | 3 | Walt Disney Pictures | false | false |
| 14 | - | 12 Rounds | $92,318 | - | 80 | - | $1,153 | $92,318 | 1 | 20th Century Fox International | true | false |
| 15 | - | Insignificant Things | $88,134 | - | 100 | - | $881 | $88,134 | 1 | Warner Bros. | true | false |
| 16 | 15 | The Unborn | $85,250 | +57.6% | 102 | +14 | $835 | $4,826,686 | 6 | Universal Pictures International (UPI) | false | false |
| 17 | 12 | The Reader | $68,967 | -39.5% | 49 | -35 | $1,407 | $610,976 | 3 | Gussi Films | false | false |
| 18 | 13 | Paul Blart: Mall Cop | $67,082 | -32.2% | 81 | -27 | $828 | $2,097,265 | 6 | Sony Pictures Releasing | false | false |
| 19 | 14 | The International | $60,295 | -22.9% | 92 | +3 | $655 | $709,454 | 5 | Sony Pictures Releasing | false | false |
| 20 | 20 | Transporter 3 | $39,176 | +73.7% | 58 | +27 | $675 | $647,618 | 9 | Zima Entertainment | false | false |
| 21 | 18 | He's Just Not That Into You | $25,163 | -26.4% | 25 | -12 | $1,006 | $1,905,002 | 7 | Gussi Films | false | false |
| 22 | - | Cherry Blossoms | $22,764 | - | 14 | - | $1,626 | $22,764 | 1 | N/A | true | false |
| 23 | 17 | Changeling | $18,922 | -62.2% | 28 | -31 | $675 | $1,873,209 | 8 | Universal Pictures International (UPI) | false | false |
| 24 | - | The Secret Life of Bees | $16,367 | - | 35 | - | $467 | $118,850 | 6 | 20th Century Fox International | false | false |
| 25 | 23 | My Sassy Girl | $16,267 | +56.6% | 32 | +18 | $508 | $428,592 | 8 | Videocine | false | false |
| 26 | 19 | The Wrestler | $15,655 | -47.3% | 20 | -28 | $782 | $549,272 | 8 | Corazón Films | false | false |
| 27 | 24 | Rachel Getting Married | $6,765 | -25.4% | 7 | - | $966 | $87,080 | 5 | Sony Pictures Releasing | false | false |
| 28 | 16 | Borderland | $5,634 | -88.8% | 33 | -46 | $170 | $117,854 | 2 | Videocine | false | false |
| 29 | 34 | Dark Matter | $5,275 | +301.8% | 14 | +12 | $376 | $22,456 | 4 | David Distribucion | false | false |
| 30 | 32 | Elegy | $4,762 | +168.1% | 10 | +3 | $476 | $167,679 | 6 | Corazón Films | false | false |
| 31 | 27 | Underworld: Rise of the Lycans | $4,049 | +34.6% | 7 | -1 | $578 | $3,835,381 | 11 | Sony Pictures Releasing | false | false |
| 32 | 21 | Milk | $4,028 | -76.3% | 8 | -20 | $503 | $540,285 | 7 | Universal Pictures International (UPI) | false | false |
| 33 | 26 | The Pink Panther 2 | $3,560 | -0.6% | 5 | -16 | $712 | $2,173,253 | 8 | Sony Pictures Releasing | false | false |
| 34 | 29 | Fierce People | $3,404 | +31.9% | 17 | +4 | $200 | $70,589 | 7 | Videocine | false | false |
| 35 | 28 | The Spirit | $2,281 | -19.7% | 10 | +1 | $228 | $466,180 | 13 | Sony Pictures Releasing | false | false |
| 36 | 25 | In Bruges | $1,909 | -55.6% | 9 | +2 | $212 | $78,736 | 5 | Corazón Films | false | false |
| 37 | 30 | Jonas Brothers: The 3D Concert Experience | $1,717 | -29.1% | 11 | - | $156 | $1,033,349 | 7 | Walt Disney Pictures | false | false |
| 38 | 39 | To Love | $349 | -43.1% | 1 | -1 | $349 | $607,678 | 8 | Gussi Films | false | false |
| 39 | 35 | Desierto adentro | $343 | -73.7% | 1 | -3 | $343 | $42,752 | 6 | Gussi Films | false | false |
| 40 | 37 | Standard Operating Procedure | $242 | -73.4% | 3 | +1 | $80 | $7,034 | 3 | N/A | false | false |
| 41 | 36 | Watchmen | $218 | -82.6% | 1 | -3 | $218 | $2,294,451 | 7 | Paramount Pictures International | false | false |
