| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Monsters vs. Aliens | $1,568,113 | -44.9% | 481 | -15 | $3,260 | $5,414,516 | 2 | United International Pictures | false | false |
| 2 | 2 | Marley & Me | $1,255,076 | -37.1% | 341 | -7 | $3,680 | $3,910,391 | 2 | 20th Century Fox International | false | false |
| 3 | - | Dragonball Evolution | $1,220,999 | - | 328 | - | $3,722 | $1,222,417 | 1 | 20th Century Fox International | true | false |
| 4 | - | Duplicity | $934,190 | - | 200 | - | $4,670 | $936,060 | 1 | United International Pictures | true | false |
| 5 | 3 | The Friends at the Margherita Cafe | $741,619 | -29.5% | 251 | -14 | $2,954 | $2,145,256 | 2 | 01 Distribution | false | false |
| 6 | - | Che: Part One | $725,853 | - | 201 | - | $3,611 | $725,853 | 1 | BIM Distribuzione | true | false |
| 7 | - | Sbirri | $633,730 | - | 224 | - | $2,829 | $633,730 | 1 | Medusa Distribuzione | true | false |
| 8 | 4 | Gran Torino | $602,974 | -40.3% | 209 | -75 | $2,885 | $9,937,361 | 5 | Warner Bros. | false | false |
| 9 | 5 | Make It Happen | $299,457 | -62.1% | 195 | -68 | $1,535 | $1,351,377 | 2 | Medusa Distribuzione | false | false |
| 10 | 9 | La matassa | $168,779 | -55.2% | 86 | -83 | $1,962 | $9,717,166 | 5 | Medusa Distribuzione | false | false |
| 11 | 8 | Push | $121,756 | -69.4% | 84 | -96 | $1,449 | $1,902,080 | 3 | Eagle Pictures | false | false |
| 12 | 6 | The New Monsters Today | $117,373 | -76.4% | 103 | -238 | $1,139 | $2,486,257 | 3 | Warner Bros. | false | false |
| 13 | 7 | Different from Whom | $117,373 | -70.6% | 78 | -134 | $1,504 | $2,486,257 | 4 | United International Pictures | false | false |
| 14 | - | Tutta colpa di Giuda | $101,543 | - | 74 | - | $1,372 | $102,910 | 1 | Warner Bros. | true | false |
| 15 | 13 | Louise hires a contract killer | $97,914 | -40% | 48 | +7 | $2,039 | $318,757 | 2 | Fandango | false | false |
| 16 | 11 | Two Lovers | $79,715 | -58.6% | 43 | -47 | $1,853 | $821,153 | 3 | BIM Distribuzione | false | false |
| 17 | 10 | He's Just Not That Into You | $67,543 | -76% | 39 | -111 | $1,731 | $3,508,807 | 4 | 01 Distribution | false | false |
| 18 | 12 | Bedtime Stories | $57,631 | -66.2% | 80 | -3 | $720 | $899,750 | 3 | Walt Disney Pictures | false | false |
| 19 | 15 | Fort Apache Napoli | $49,101 | -60.1% | 34 | -34 | $1,444 | $785,422 | 3 | 01 Distribution | false | false |
| 20 | 16 | Ponyo | $28,620 | -63.6% | 64 | -61 | $447 | $930,204 | 4 | Lucky Red | false | false |
| 21 | 17 | The International | $26,877 | -65.5% | 31 | -31 | $867 | $1,375,443 | 4 | Sony Pictures Releasing | false | false |
| 22 | 37 | The Pink Panther 2 | $863 | -64.2% | 15 | +8 | $57 | $1,284,973 | 6 | Sony Pictures Releasing | false | false |
