| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Monsters vs. Aliens | $2,847,365 | - | 496 | - | $5,740 | $2,847,365 | 1 | United International Pictures | true | false |
| 2 | - | Marley & Me | $1,993,868 | - | 348 | - | $5,729 | $1,994,774 | 1 | 20th Century Fox International | true | false |
| 3 | - | The Friends at the Margherita Cafe | $1,052,417 | - | 265 | - | $3,971 | $1,052,417 | 1 | 01 Distribution | true | false |
| 4 | 1 | Gran Torino | $1,009,663 | -39.6% | 284 | -39 | $3,555 | $9,182,277 | 4 | Warner Bros. | false | false |
| 5 | - | Make It Happen | $789,132 | - | 263 | - | $3,000 | $789,132 | 1 | Medusa Distribuzione | true | false |
| 6 | 2 | The New Monsters Today | $498,063 | -64.8% | 341 | -65 | $1,460 | $2,283,731 | 2 | Warner Bros. | false | false |
| 7 | 4 | Different from Whom | $398,636 | -63.5% | 212 | -146 | $1,880 | $3,841,760 | 3 | United International Pictures | false | false |
| 8 | 5 | Push | $397,428 | -58.5% | 180 | -17 | $2,207 | $1,661,783 | 2 | Eagle Pictures | false | false |
| 9 | 3 | La matassa | $376,842 | -66.8% | 169 | -149 | $2,229 | $9,638,637 | 4 | Medusa Distribuzione | false | false |
| 10 | 6 | He's Just Not That Into You | $280,875 | -68.4% | 150 | -148 | $1,872 | $3,387,226 | 3 | 01 Distribution | false | false |
| 11 | 10 | Two Lovers | $192,736 | -45.8% | 90 | -18 | $2,141 | $694,653 | 2 | BIM Distribuzione | false | false |
| 12 | 8 | Bedtime Stories | $170,470 | -66.1% | 83 | -4 | $2,053 | $791,498 | 2 | Walt Disney Pictures | false | false |
| 13 | - | Louise hires a contract killer | $163,176 | - | 41 | - | $3,979 | $163,176 | 1 | Fandango | true | false |
| 14 | 7 | The Case of Unfaithful Klara | $148,916 | -76% | 155 | -107 | $960 | $991,709 | 2 | Medusa Distribuzione | false | false |
| 15 | 12 | Fort Apache Napoli | $122,986 | -51.6% | 68 | -44 | $1,808 | $695,575 | 2 | 01 Distribution | false | false |
| 16 | 11 | Ponyo | $78,682 | -74.9% | 125 | -44 | $629 | $890,582 | 3 | Lucky Red | false | false |
| 17 | 9 | The International | $77,882 | -79.7% | 62 | -98 | $1,256 | $1,394,928 | 3 | Sony Pictures Releasing | false | false |
| 18 | 13 | Slumdog Millionaire | $45,545 | -69% | 33 | -37 | $1,380 | $8,043,825 | 18 | Lucky Red | false | false |
| 19 | 20 | Teza | $37,785 | -32.1% | 19 | -2 | $1,988 | $122,720 | 2 | Ripley's Film | false | false |
| 20 | 15 | The Reader | $27,756 | -61.4% | 15 | -14 | $1,850 | $3,956,702 | 7 | 01 Distribution | false | false |
| 21 | 17 | Cenci in Cina | $27,525 | -60.7% | 7 | +1 | $3,932 | $129,951 | 2 | N/A | false | false |
| 22 | 18 | The Wrestler | $26,517 | -56% | 15 | -24 | $1,767 | $2,824,964 | 5 | Lucky Red | false | false |
| 23 | 25 | Frozen River | $19,930 | -32% | 11 | -2 | $1,811 | $184,654 | 4 | Archibald | false | false |
| 24 | 24 | The Wave | $19,075 | -40.3% | 14 | -4 | $1,362 | $574,820 | 6 | BIM Distribuzione | false | false |
| 25 | 21 | Due partite | $16,400 | -68.7% | 12 | -25 | $1,366 | $2,027,829 | 5 | 01 Distribution | false | false |
| 26 | 39 | Katyn | $11,603 | +65% | 5 | -2 | $2,320 | $99,729 | 8 | N/A | false | false |
| 27 | 19 | Trappola d'autore | $10,775 | -80.9% | 2 | -7 | $5,387 | $118,875 | 2 | N/A | false | false |
| 28 | 29 | Easy Virtue | $8,488 | -29.8% | 3 | -1 | $2,829 | $3,307,829 | 13 | Eagle Pictures | false | false |
| 29 | 22 | The Curious Case of Benjamin Button | $6,057 | -87.5% | 5 | -20 | $1,211 | $14,653,425 | 8 | Warner Bros. | false | false |
| 30 | 30 | Giulia Doesn't Date at Night | $4,754 | -59% | 3 | -6 | $1,584 | $1,118,316 | 6 | 01 Distribution | false | false |
| 31 | 37 | Ex | $4,344 | -48.6% | 3 | -3 | $1,448 | $14,706,933 | 9 | 01 Distribution | false | false |
| 32 | 38 | Revolutionary Road | $3,418 | -58.7% | 3 | -1 | $1,139 | $4,832,138 | 10 | Universal Pictures International (UPI) | false | false |
| 33 | 46 | The Sicilian Girl | $3,403 | +6.8% | 7 | +2 | $486 | $199,438 | 6 | Istituto Luce | false | false |
| 34 | 27 | Inkheart | $3,168 | -80.8% | 9 | -9 | $352 | $3,289,477 | 7 | Eagle Pictures | false | false |
| 35 | - | Il solitario | $2,870 | - | 1 | - | $2,870 | $8,799 | 1 | N/A | true | false |
| 36 | 16 | Watchmen | $2,712 | -96.2% | 4 | -38 | $678 | $3,721,232 | 5 | Universal Pictures International (UPI) | false | false |
| 37 | 26 | The Pink Panther 2 | $2,413 | -91.3% | 7 | -23 | $344 | $1,363,390 | 5 | Sony Pictures Releasing | false | false |
| 38 | 40 | Lemon Tree | $2,273 | -52.2% | 2 | -2 | $1,136 | $1,471,720 | 17 | Teodora Film | false | false |
| 39 | 32 | L'ultimo Crodino | $2,026 | -79.2% | 4 | -4 | $506 | $106,456 | 3 | Mikado Film | false | false |
| 40 | 48 | Mar nero | $1,550 | -17.3% | 1 | -1 | $1,550 | $128,060 | 10 | N/A | false | false |
| 41 | - | Dall'altra parte del mare | $1,543 | - | 1 | - | $1,543 | $2,945 | 2 | N/A | false | false |
| 42 | - | Pa-ra-da | $1,520 | - | 1 | - | $1,520 | $305,344 | 29 | 01 Distribution | false | false |
| 43 | - | Legami di sangue | $1,449 | - | 1 | - | $1,449 | $2,858 | 2 | N/A | false | false |
| 44 | 34 | Eden Is West | $1,383 | -85.3% | 2 | -9 | $691 | $550,811 | 5 | Medusa Distribuzione | false | false |
| 45 | 41 | Empties | $1,317 | -72.3% | 2 | -3 | $658 | $428,775 | 12 | Fandango | false | false |
| 46 | - | One Day in a Life | $1,317 | - | 1 | - | $1,317 | $428,775 | 22 | Ripley's Film | false | false |
| 47 | - | Juno | $1,099 | - | 1 | - | $1,099 | $3,352,339 | 53 | 20th Century Fox International | false | false |
| 48 | 14 | Confessions of a Shopaholic | $1,014 | -98.9% | 2 | -56 | $507 | $6,192,300 | 6 | Walt Disney Pictures | false | false |
| 49 | - | Frost/Nixon | $939 | - | 1 | - | $939 | $879,567 | 9 | Universal Pictures International (UPI) | false | false |
| 50 | - | The Duchess | $776 | - | 2 | - | $388 | $2,901,441 | 15 | BIM Distribuzione | false | false |
