| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | La matassa | $2,370,034 | -31.7% | 498 | -16 | $4,759 | $7,270,364 | 2 | Medusa Distribuzione | false | false |
| 2 | 2 | Gran Torino | $1,923,509 | -11.9% | 332 | +14 | $5,793 | $5,202,954 | 2 | Warner Bros. | false | false |
| 3 | - | Different from Whom | $1,406,463 | - | 364 | - | $3,863 | $1,406,463 | 1 | United International Pictures | true | false |
| 4 | - | He's Just Not That Into You | $1,358,026 | - | 323 | - | $4,204 | $1,363,131 | 1 | 01 Distribution | true | false |
| 5 | - | The International | $587,970 | - | 170 | - | $3,458 | $587,970 | 1 | Sony Pictures Releasing | true | false |
| 6 | - | Ponyo | $321,459 | - | 184 | - | $1,747 | $321,432 | 1 | Lucky Red | true | false |
| 7 | 4 | Confessions of a Shopaholic | $301,837 | -55.8% | 157 | -107 | $1,922 | $6,018,167 | 4 | Walt Disney Pictures | false | false |
| 8 | 3 | Watchmen | $292,015 | -60% | 163 | -151 | $1,791 | $3,514,358 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Slumdog Millionaire | $234,119 | -39.6% | 107 | -41 | $2,188 | $7,755,331 | 16 | Lucky Red | false | false |
| 10 | 5 | The Wrestler | $220,725 | -58.9% | 135 | -153 | $1,635 | $2,634,202 | 3 | Lucky Red | false | false |
| 11 | 9 | The Curious Case of Benjamin Button | $160,669 | -53.6% | 77 | -67 | $2,086 | $14,635,214 | 6 | Warner Bros. | false | false |
| 12 | 6 | Due partite | $153,181 | -65.2% | 111 | -96 | $1,380 | $1,876,697 | 3 | 01 Distribution | false | false |
| 13 | 11 | The Reader | $127,974 | -40.6% | 64 | -41 | $1,999 | $3,062,813 | 5 | 01 Distribution | false | false |
| 14 | 8 | Mesrine: Killer Instinct | $118,952 | -66.9% | 106 | -72 | $1,122 | $659,373 | 2 | Eagle Pictures | false | false |
| 15 | - | Fort Apache Napoli | $114,464 | - | 54 | - | $2,119 | $114,464 | - | 01 Distribution | - | false |
| 16 | 10 | The Pink Panther 2 | $111,063 | -63.6% | 99 | -91 | $1,121 | $1,320,650 | 3 | Sony Pictures Releasing | false | false |
| 17 | - | L'ultimo Crodino | $70,851 | - | 101 | - | $701 | $70,851 | 1 | Mikado Film | true | false |
| 18 | 12 | The Unborn | $66,994 | -66.1% | 42 | -57 | $1,595 | $2,493,660 | 4 | Universal Pictures International (UPI) | false | false |
| 19 | 19 | The Wave | $51,064 | +1.5% | 31 | +4 | $1,647 | $475,812 | 4 | BIM Distribuzione | false | false |
| 20 | 17 | Giulia Doesn't Date at Night | $49,327 | -39.8% | 31 | -22 | $1,591 | $1,081,982 | 4 | 01 Distribution | false | false |
| 21 | 21 | Frozen River | $44,019 | +32.6% | 20 | +5 | $2,200 | $93,831 | 2 | Archibald | false | false |
| 22 | 16 | Inkheart | $40,600 | -60.6% | 39 | -52 | $1,041 | $3,045,739 | 5 | Eagle Pictures | false | false |
| 23 | 15 | Live! | $40,236 | -66.9% | 32 | -39 | $1,257 | $517,841 | 3 | Moviemax | false | false |
| 24 | 14 | Ex | $38,569 | -69.6% | 21 | -31 | $1,836 | $14,689,932 | 7 | 01 Distribution | false | false |
| 25 | 20 | Journey to the Center of the Earth | $37,076 | -10.5% | 16 | -4 | $2,317 | $10,037,592 | 10 | 01 Distribution | false | false |
| 26 | 13 | Iago | $23,273 | -82.4% | 28 | -71 | $831 | $2,674,100 | 4 | Medusa Distribuzione | false | false |
| 27 | 23 | Milk | $20,071 | -35.9% | 13 | -5 | $1,543 | $3,041,799 | 9 | BIM Distribuzione | false | false |
| 28 | 28 | In the Name of the King: A Dungeon Siege Tale | $15,432 | +39.3% | 13 | +4 | $1,187 | $34,923 | 4 | One Movie | false | false |
| 29 | 24 | Underworld: Rise of the Lycans | $13,626 | -36.9% | 20 | -2 | $681 | $1,511,866 | 5 | Sony Pictures Releasing | false | false |
| 30 | 29 | Márió, a varázsló | $11,135 | +0.5% | 3 | - | $3,711 | $206,820 | 17 | L'Altrofilm | false | false |
| 31 | - | Aria | $9,378 | - | 18 | - | $521 | $9,378 | 1 | N/A | true | false |
| 32 | 36 | Katyn | $9,309 | +89.7% | 11 | +7 | $846 | $63,954 | 6 | N/A | false | false |
| 33 | 32 | Lemon Tree | $7,359 | +4.1% | 6 | - | $1,226 | $1,346,436 | 15 | Teodora Film | false | false |
| 34 | 39 | Easy Virtue | $6,666 | +45% | 7 | +4 | $952 | $3,295,041 | 11 | Eagle Pictures | false | false |
| 35 | 43 | The Boy in the Striped Pajamas | $6,635 | +84.5% | 7 | -2 | $947 | $3,334,656 | 14 | Walt Disney Pictures | false | false |
| 36 | 27 | Doubt | $6,415 | -58.3% | 8 | -10 | $801 | $2,302,842 | 8 | Walt Disney Pictures | false | false |
| 37 | 18 | Eden Is West | $6,297 | -90.7% | 11 | -86 | $572 | $498,348 | 3 | Medusa Distribuzione | false | false |
| 38 | 26 | Revolutionary Road | $6,287 | -60.8% | 8 | -2 | $785 | $4,844,340 | 8 | Universal Pictures International (UPI) | false | false |
| 39 | 25 | Impy's Wonderland | $6,234 | -66.3% | 25 | -36 | $249 | $254,230 | 4 | Mediafilm | false | false |
| 40 | 22 | L'ultimo Pulcinella | $5,798 | -81.5% | 5 | -16 | $1,159 | $56,978 | 2 | Bolero Film | false | false |
| 41 | 30 | I've Loved You So Long | $5,585 | -41% | 4 | -1 | $1,396 | $552,731 | 7 | Mikado Film | false | false |
| 42 | 38 | The Sicilian Girl | $5,494 | +19.2% | 9 | +1 | $610 | $181,301 | 4 | Istituto Luce | false | false |
| 43 | 40 | Mar nero | $3,845 | -1.8% | 3 | -1 | $1,281 | $118,699 | 8 | N/A | false | false |
| 44 | 33 | Beverly Hills Chihuahua | $3,460 | -41.4% | 7 | -4 | $494 | $5,244,509 | 10 | Walt Disney Pictures | false | false |
| 45 | - | Impotenti esistenziali | $2,844 | - | 2 | - | $1,422 | $6,024 | 1 | N/A | true | false |
| 46 | 48 | The Breath of the Soul | $2,740 | +43.5% | 3 | -1 | $913 | $5,676 | 2 | N/A | false | false |
| 47 | 44 | The Visitor | $2,362 | -19.4% | 6 | +3 | $393 | $1,990,512 | 16 | Bolero Film | false | false |
| 48 | 46 | Questo piccolo grande amore | $2,281 | -2.4% | 3 | - | $760 | $4,878,552 | 6 | Medusa Distribuzione | false | false |
| 49 | 31 | Il Sogno nel casello | $2,165 | -76.4% | 3 | -4 | $721 | $14,604 | 2 | - | false | false |
| 50 | 45 | Waltz with Bashir | $2,129 | -21.9% | 3 | -3 | $709 | $1,041,913 | 11 | Lucky Red | false | false |
| 51 | 51 | Hotel for Dogs | $857 | -16.2% | 2 | -2 | $428 | $90,310 | 5 | Universal Pictures International (UPI) | false | false |
| 52 | 34 | Valkyrie | $690 | -87.5% | 2 | -2 | $345 | $6,094,571 | 8 | 01 Distribution | false | false |
