| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Paul Blart: Mall Cop | $431,258 | - | 29 | - | $14,870 | $431,258 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Slumdog Millionaire | $342,706 | +14% | 47 | +3 | $7,291 | $4,322,079 | 12 | Pathé | false | false |
| 3 | 2 | Gran Torino | $255,949 | -7.8% | 53 | +3 | $4,829 | $1,938,451 | 5 | Warner Bros. | false | false |
| 4 | 5 | The Reader | $178,101 | +8.6% | 4 | -26 | $44,525 | $1,075,367 | 6 | Ascot Elite Entertainment Group | false | false |
| 5 | - | Beverly Hills Chihuahua | $153,203 | - | 53 | - | $2,890 | $235,148 | 11 | Walt Disney Pictures | false | false |
| 6 | 6 | Will You Marry Us? | $145,581 | -7% | 31 | - | $4,696 | $337,565 | 2 | Walt Disney Pictures | false | false |
| 7 | - | Duplicity | $143,454 | - | 15 | - | $9,563 | $154,974 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 3 | Marley & Me | $133,065 | -27.3% | 53 | -18 | $2,510 | $1,279,535 | 4 | 20th Century Fox International | false | false |
| 9 | 4 | Coco | $116,719 | -29.3% | 14 | +4 | $8,337 | $313,526 | 2 | JMH Distribution | false | false |
| 10 | 7 | Confessions of a Shopaholic | $84,201 | -28% | 27 | -17 | $3,118 | $464,316 | 5 | Walt Disney Pictures | false | false |
| 11 | - | Che: Part One | $69,954 | - | 12 | - | $5,829 | $205,809 | 12 | Ascot Elite Entertainment Group | false | false |
| 12 | 14 | Mid-August Lunch | $59,267 | +13% | 12 | -1 | $4,938 | $257,580 | 17 | Xenix Filmdistribution | false | false |
| 13 | 12 | Milk | $53,830 | -8.3% | 22 | -7 | $2,446 | $790,255 | 10 | Ascot Elite Entertainment Group | false | false |
| 14 | 17 | The Tale of Despereaux | $48,184 | +18.5% | 28 | -10 | $1,720 | $191,882 | 7 | Universal Pictures International (UPI) | false | false |
| 15 | 21 | Lilly the Witch: The Dragon and the Magic Book | $44,425 | +34.3% | 34 | -4 | $1,306 | $508,100 | 6 | Walt Disney Pictures | false | false |
| 16 | - | Red Cliff | $44,299 | - | 8 | - | $5,537 | $46,918 | 1 | Ascot Elite Entertainment Group | true | false |
| 17 | 16 | Hotel for Dogs | $42,142 | -4.4% | 2 | -45 | $21,071 | $931,573 | 8 | Universal Pictures International (UPI) | false | false |
| 18 | 10 | The Pink Panther 2 | $37,082 | -39.6% | 25 | -13 | $1,483 | $325,383 | 6 | Walt Disney Pictures | false | false |
| 19 | 15 | He's Just Not That Into You | $36,057 | -23.4% | 10 | -6 | $3,605 | $916,209 | 7 | Warner Bros. | false | false |
| 20 | - | Home | $34,437 | - | 11 | - | $3,130 | $931,197 | 24 | Filmcoopi Zürich | false | false |
| 21 | 9 | Watchmen | $34,347 | -46.8% | 15 | -10 | $2,289 | $594,913 | 4 | N/A | false | false |
| 22 | 13 | Last Chance Harvey | $32,756 | -44.1% | 13 | - | $2,519 | $105,439 | 2 | Ascot Elite Entertainment Group | false | false |
| 23 | 8 | The Unborn | $31,725 | -53.2% | 16 | -8 | $1,982 | $236,410 | 3 | Universal Pictures International (UPI) | false | false |
| 24 | 11 | Yes Man | $30,435 | -49.6% | 18 | -5 | $1,690 | $1,342,175 | 12 | Warner Bros. | false | false |
| 25 | 19 | Twilight | $28,513 | -24.6% | 15 | -3 | $1,900 | $2,986,625 | 19 | Ascot Elite Entertainment Group | false | false |
| 26 | 20 | The International | $23,295 | -32.5% | 12 | -2 | $1,941 | $697,055 | 7 | Walt Disney Pictures | false | false |
| 27 | 25 | Fly Me to the Moon 3D | $4,180 | +37.9% | 1 | - | $4,180 | $130,523 | 22 | N/A | false | false |
