| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Confessions of a Shopaholic | $1,126,802 | -37.7% | 309 | - | $3,646 | $3,593,747 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Paul Blart: Mall Cop | $1,088,447 | - | 196 | - | $5,553 | $1,092,322 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Duplicity | $1,039,004 | - | 224 | - | $4,638 | $1,039,004 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Watchmen | $573,611 | -47.5% | 316 | -39 | $1,815 | $5,289,314 | 3 | Paramount Pictures International | false | false |
| 5 | 3 | Slumdog Millionaire | $309,870 | -33.8% | 195 | -17 | $1,589 | $12,693,594 | 14 | Icon Film Distribution | false | false |
| 6 | 7 | Gran Torino | $255,174 | -32.4% | 193 | -6 | $1,322 | $10,139,716 | 9 | Roadshow Films | false | false |
| 7 | - | 12 Rounds | $255,008 | - | 134 | - | $1,903 | $255,008 | 1 | 20th Century Fox International | true | false |
| 8 | 4 | Notorious | $226,954 | -50.7% | 126 | - | $1,801 | $859,013 | 2 | 20th Century Fox International | false | false |
| 9 | 6 | He's Just Not That Into You | $198,890 | -48.8% | 177 | -49 | $1,123 | $9,661,311 | 6 | Roadshow Films | false | false |
| 10 | 8 | Easy Virtue | $194,999 | -11.7% | 49 | - | $3,979 | $595,439 | 2 | Hopscotch Films | false | false |
| 11 | 9 | The Reader | $152,062 | -29.4% | 53 | - | $2,869 | $2,013,044 | 5 | Roadshow Films | false | false |
| 12 | 5 | Friday the 13th | $146,733 | -64% | 142 | - | $1,033 | $683,658 | 2 | Paramount Pictures International | false | false |
| 13 | 11 | Love the Beast | $96,968 | -39.1% | 65 | +6 | $1,491 | $341,985 | 2 | Madman Entertainment | false | false |
| 14 | 10 | Last Chance Harvey | $92,430 | -48.5% | 109 | -35 | $847 | $1,513,417 | 4 | Icon Film Distribution | false | false |
| 15 | - | Two Fists, One Heart | $66,574 | - | 50 | - | $1,331 | $87,174 | 1 | Walt Disney Pictures | true | false |
| 16 | 12 | The Unborn | $56,394 | -62.7% | 63 | -62 | $895 | $1,450,583 | 4 | Universal Pictures International (UPI) | false | false |
| 17 | 13 | New in Town | $37,273 | -75.2% | 108 | -61 | $345 | $762,347 | 3 | Icon Film Distribution | false | false |
| 18 | 15 | Twilight | $35,850 | -47.1% | 43 | -19 | $833 | $14,800,307 | 16 | - | false | false |
| 19 | 16 | Changeling | $35,004 | -37.5% | 67 | -21 | $522 | $2,577,102 | 7 | Universal Pictures International (UPI) | false | false |
| 20 | - | Blindness | $32,219 | - | 41 | - | $785 | $32,219 | 1 | Roadshow Films | true | false |
| 21 | 18 | Hotel for Dogs | $30,100 | -43.3% | 70 | -32 | $430 | $4,064,233 | 10 | Paramount Pictures International | false | false |
| 22 | 19 | The Combination | $29,288 | -39.3% | 25 | -4 | $1,171 | $423,915 | 4 | - | false | false |
| 23 | 17 | Milk | $28,590 | -47.5% | 32 | -10 | $893 | $1,255,565 | 8 | Universal Pictures International (UPI) | false | false |
| 24 | 52 | Under the Sea 3D | $26,627 | +3,608.5% | 2 | +1 | $13,313 | $28,631 | 4 | IMAX | false | false |
| 25 | 21 | Dean Spanley 2008 Re-release | $21,086 | -48% | 29 | -5 | $727 | $171,117 | 3 | Paramount Pictures International | false | false |
| 26 | 14 | The International | $19,690 | -76.2% | 36 | -69 | $546 | $1,955,162 | 5 | Sony Pictures Releasing | false | false |
| 27 | 22 | The Secret Life of Bees | $16,362 | -59.4% | 31 | -13 | $527 | $232,914 | 3 | 20th Century Fox International | false | false |
| 28 | - | Let the Right One In | $15,836 | - | 2 | - | $7,918 | $24,248 | 3 | Rialto Distribution | false | false |
| 29 | - | Bottle Shock | $12,666 | - | 25 | - | $506 | $12,666 | - | Roadshow Films | - | false |
| 30 | 31 | Of Time and the City | $12,198 | +45.9% | 5 | +1 | $2,439 | $25,977 | 2 | Sharmill Films | false | false |
| 31 | 20 | Ghost Town | $12,091 | -72.3% | 41 | -38 | $294 | $2,499,993 | 6 | Paramount Pictures International | false | false |
| 32 | 23 | Australia | $10,181 | -66.8% | 26 | -14 | $391 | $25,447,209 | 17 | 20th Century Fox International | false | false |
| 33 | 29 | I've Loved You So Long | $9,699 | -14% | 16 | -3 | $606 | $1,477,936 | 13 | Palace Films | false | false |
| 34 | 25 | My Bloody Valentine | $9,001 | -55.7% | 10 | -6 | $900 | $1,231,995 | 6 | Hoyts Distribution | false | false |
| 35 | 27 | Wild Ocean | $8,444 | -28.3% | 1 | -1 | $8,444 | $1,192,725 | 40 | IMAX | false | false |
| 36 | - | Kung Fu Chefs | $6,933 | - | 5 | - | $1,386 | $6,933 | 1 | MG Distribution | true | false |
| 37 | 42 | Marley & Me | $6,049 | +30.2% | 12 | - | $504 | $6,888,883 | 12 | 20th Century Fox International | false | false |
| 38 | 26 | Revolutionary Road | $5,328 | -58.7% | 11 | -8 | $484 | $2,114,175 | 9 | Paramount Pictures International | false | false |
| 39 | 36 | Transporter 3 | $4,427 | -27.7% | 17 | -5 | $260 | $2,247,776 | 7 | Icon Film Distribution | false | false |
| 40 | 43 | Fly Me to the Moon 3D | $3,930 | -12.8% | 2 | - | $1,965 | $492,256 | 27 | IMAX | false | false |
| 41 | 37 | Rachel Getting Married | $3,551 | -36.1% | 11 | +1 | $322 | $430,370 | 6 | Sony Pictures Releasing | false | false |
| 42 | - | A Complete History of My Sexual Failures | $3,257 | - | 3 | - | $1,085 | $3,257 | 1 | Madman Entertainment | true | false |
| 43 | 30 | The Curious Case of Benjamin Button | $3,181 | -62.5% | 16 | -5 | $198 | $11,327,798 | 13 | Warner Bros. | false | false |
| 44 | 34 | Bride Wars | $3,176 | -52.7% | 10 | -15 | $317 | $7,880,947 | 10 | 20th Century Fox International | false | false |
| 45 | 48 | Grand Canyon Adventure: River at Risk | $2,823 | +21.5% | 1 | - | $2,823 | $381,580 | 40 | IMAX | false | false |
| 46 | 38 | The Class | $2,708 | -48.1% | 6 | - | $451 | $261,670 | 9 | Sony Pictures Releasing | false | false |
| 47 | 35 | Valkyrie | $2,668 | -56.7% | 5 | -11 | $533 | $4,287,078 | 9 | 20th Century Fox International | false | false |
| 48 | 40 | Frozen River | $2,519 | -48.4% | 3 | - | $839 | $39,389 | 5 | Sony Pictures Releasing | false | false |
| 49 | 46 | Role Models | $2,321 | -3.7% | 11 | +1 | $211 | $4,494,103 | 10 | Universal Pictures International (UPI) | false | false |
| 50 | 44 | The Tale of Despereaux | $2,194 | -48.9% | 12 | -4 | $182 | $1,599,837 | 11 | Universal Pictures International (UPI) | false | false |
| 51 | 24 | Zack and Miri Make a Porno | $2,164 | -91.9% | 6 | -36 | $360 | $1,270,158 | 5 | Roadshow Films | false | false |
| 52 | 32 | W. | $1,898 | -75% | 6 | -10 | $316 | $166,706 | 4 | Hoyts Distribution | false | false |
| 53 | - | Salvation | $1,553 | - | 3 | - | $517 | $1,553 | 1 | Hopscotch Films | true | false |
| 54 | 49 | The Human Body Undated Australia Release | $1,371 | -29.9% | 2 | - | $685 | $1,000,043 | 30 | IMAX | false | false |
| 55 | 45 | Dinosaurs: Giants of Patagonia | $827 | -80.2% | 1 | -1 | $827 | $2,081,999 | 94 | IMAX | false | false |
| 56 | - | Antarctica | $630 | - | 2 | - | $315 | $3,949,820 | - | IMAX | - | false |
| 57 | 50 | African Adventure: Safari in the Okavango | $566 | -66.4% | 1 | - | $566 | $777,972 | 105 | IMAX | false | false |
| 58 | 39 | Beautiful | $527 | -89.3% | 7 | -13 | $75 | $32,024 | 3 | Jump Street Films | false | false |
| 59 | 33 | Frost/Nixon | $497 | -92.8% | 2 | -6 | $248 | $1,337,135 | 13 | Universal Pictures International (UPI) | false | false |
| 60 | 41 | Deep Sea | $469 | -90.1% | 2 | - | $234 | $3,540,178 | 160 | IMAX | false | false |
| 61 | 55 | Shackleton's Antarctic Adventure | $459 | +18.9% | 1 | - | $459 | $4,025,983 | 386 | N/A | false | false |
| 62 | - | Mummies... | $408 | - | 1 | - | $408 | $115,745 | 85 | IMAX | false | false |
