| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | La matassa | $3,469,484 | - | 514 | - | $6,749 | $3,469,484 | 1 | Medusa Distribuzione | true | false |
| 2 | - | Gran Torino | $2,182,317 | - | 318 | - | $6,862 | $2,182,317 | 1 | Warner Bros. | true | false |
| 3 | 1 | Watchmen | $730,266 | -50.7% | 314 | -30 | $2,325 | $2,807,932 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 2 | Confessions of a Shopaholic | $682,931 | -46.8% | 264 | -78 | $2,586 | $5,257,185 | 3 | Walt Disney Pictures | false | false |
| 5 | 3 | The Wrestler | $537,171 | -51.6% | 288 | -27 | $1,865 | $2,186,155 | 2 | Lucky Red | false | false |
| 6 | 5 | Due partite | $439,654 | -39.2% | 207 | -3 | $2,123 | $1,477,138 | 2 | 01 Distribution | false | false |
| 7 | 7 | Slumdog Millionaire | $387,692 | -34.7% | 148 | -12 | $2,619 | $7,025,806 | 15 | Lucky Red | false | false |
| 8 | - | Mesrine: Killer Instinct | $359,907 | - | 178 | - | $2,021 | $359,907 | 1 | Eagle Pictures | true | false |
| 9 | 4 | The Curious Case of Benjamin Button | $346,212 | -58.6% | 144 | -138 | $2,404 | $13,671,255 | 5 | Warner Bros. | false | false |
| 10 | 6 | The Pink Panther 2 | $304,756 | -50.5% | 190 | -8 | $1,603 | $1,093,464 | 2 | Sony Pictures Releasing | false | false |
| 11 | 10 | The Reader | $215,277 | -43.8% | 105 | -29 | $2,050 | $2,720,619 | 4 | 01 Distribution | false | false |
| 12 | 9 | The Unborn | $197,708 | -60.3% | 99 | -74 | $1,997 | $2,254,513 | 3 | Universal Pictures International (UPI) | false | false |
| 13 | 8 | Iago | $132,346 | -75.6% | 99 | -177 | $1,336 | $2,508,899 | 3 | Medusa Distribuzione | false | false |
| 14 | 11 | Ex | $127,012 | -63.2% | 52 | -81 | $2,442 | $13,621,185 | 6 | 01 Distribution | false | false |
| 15 | 14 | Live! | $121,639 | -46.6% | 71 | -3 | $1,713 | $453,640 | 2 | Moviemax | false | false |
| 16 | 13 | Inkheart | $102,938 | -63.9% | 91 | -68 | $1,131 | $3,070,775 | 4 | Eagle Pictures | false | false |
| 17 | 15 | Giulia Doesn't Date at Night | $81,893 | -55.6% | 53 | -51 | $1,545 | $951,022 | 3 | 01 Distribution | false | false |
| 18 | 12 | Eden Is West | $67,737 | -78.1% | 97 | -82 | $698 | $483,902 | 2 | Medusa Distribuzione | false | false |
| 19 | 16 | The Wave | $50,317 | -34.2% | 27 | -12 | $1,863 | $373,985 | 3 | BIM Distribuzione | false | false |
| 20 | 18 | Journey to the Center of the Earth | $41,424 | -37.6% | 20 | -5 | $2,071 | $10,267,808 | 9 | 01 Distribution | false | false |
| 21 | - | Frozen River | $33,196 | - | 15 | - | $2,213 | $33,196 | 1 | Archibald | true | false |
| 22 | - | L'ultimo Pulcinella | $31,378 | - | 21 | - | $1,494 | $35,916 | 1 | Bolero Film | true | false |
| 23 | 19 | Milk | $31,308 | -45.4% | 18 | -7 | $1,739 | $3,004,872 | 8 | BIM Distribuzione | false | false |
| 24 | 17 | Underworld: Rise of the Lycans | $21,579 | -71.2% | 22 | -42 | $980 | $1,490,885 | 4 | Sony Pictures Releasing | false | false |
| 25 | 21 | Impy's Wonderland | $18,507 | -55.6% | 61 | -30 | $303 | $244,569 | 3 | Mediafilm | false | false |
| 26 | 20 | Revolutionary Road | $16,021 | -62% | 10 | -9 | $1,602 | $4,305,238 | 7 | Universal Pictures International (UPI) | false | false |
| 27 | 22 | Doubt | $15,395 | -45.1% | 18 | -1 | $855 | $2,285,828 | 7 | Walt Disney Pictures | false | false |
| 28 | - | In the Name of the King: A Dungeon Siege Tale | $11,081 | - | 9 | - | $1,231 | $16,449 | 3 | One Movie | false | false |
| 29 | 25 | Márió, a varázsló | $11,079 | -32.4% | 3 | -1 | $3,693 | $186,655 | 16 | L'Altrofilm | false | false |
| 30 | 27 | I've Loved You So Long | $9,464 | -28.4% | 5 | -1 | $1,892 | $502,067 | 6 | Mikado Film | false | false |
| 31 | - | Il Sogno nel casello | $9,178 | - | 7 | - | $1,311 | $9,178 | 1 | A.B. Film | true | false |
| 32 | 36 | Lemon Tree | $7,070 | +36% | 6 | +1 | $1,178 | $1,329,273 | 14 | Teodora Film | false | false |
| 33 | 28 | Beverly Hills Chihuahua | $5,900 | -44.8% | 11 | -9 | $536 | $4,855,504 | 9 | Walt Disney Pictures | false | false |
| 34 | 31 | Valkyrie | $5,524 | -34.1% | 4 | -4 | $1,381 | $5,701,134 | 7 | 01 Distribution | false | false |
| 35 | 45 | Italians | $5,053 | +111.5% | 3 | - | $1,684 | $17,026,331 | 8 | Filmauro | false | false |
| 36 | 34 | Katyn | $4,908 | -12.9% | 4 | -3 | $1,227 | $52,268 | 5 | N/A | false | false |
| 37 | 32 | Empties | $4,900 | -41.1% | 3 | -2 | $1,633 | $394,246 | 9 | Fandango | false | false |
| 38 | 24 | The Sicilian Girl | $4,608 | -79.7% | 8 | -11 | $576 | $157,964 | 3 | Istituto Luce | false | false |
| 39 | 29 | Easy Virtue | $4,596 | -53.1% | 3 | -1 | $1,532 | $3,124,313 | 10 | Eagle Pictures | false | false |
| 40 | 39 | Mar nero | $3,915 | +33% | 4 | +2 | $978 | $104,508 | 7 | N/A | false | false |
| 41 | 41 | Space Chimps | $3,755 | +30.3% | 12 | +4 | $312 | $719,060 | 6 | Medusa Distribuzione | false | false |
| 42 | 23 | Bride Wars | $3,656 | -86.7% | 6 | -25 | $609 | $1,695,914 | 4 | 20th Century Fox International | false | false |
| 43 | 37 | The Boy in the Striped Pajamas | $3,597 | -20.5% | 9 | +1 | $399 | $3,375,931 | 13 | Walt Disney Pictures | false | false |
| 44 | 35 | The Visitor | $2,929 | -46.5% | 3 | -2 | $976 | $1,838,102 | 15 | Bolero Film | false | false |
| 45 | - | Waltz with Bashir | $2,727 | - | 6 | - | $454 | $980,231 | 10 | Lucky Red | false | false |
| 46 | 38 | Questo piccolo grande amore | $2,336 | -41.1% | 3 | -6 | $778 | $4,875,442 | 5 | Medusa Distribuzione | false | false |
| 47 | - | We Can Do That | $2,036 | - | 3 | - | $678 | $2,379,552 | 20 | Warner Bros. | false | false |
| 48 | - | The Breath of the Soul | $1,909 | - | 4 | - | $477 | $1,909 | 1 | N/A | true | false |
| 49 | 43 | Friday the 13th | $1,400 | -49.6% | 1 | -5 | $1,400 | $1,613,528 | 5 | Universal Pictures International (UPI) | false | false |
| 50 | - | My Enemy's Enemy | $1,335 | - | 1 | - | $1,335 | $3,141 | 92 | Mikado Film | false | false |
| 51 | 49 | Hotel for Dogs | $1,023 | -27.1% | 4 | -4 | $255 | $89,322 | 4 | Universal Pictures International (UPI) | false | false |
| 52 | 33 | Frost/Nixon | $999 | -87.9% | 1 | -5 | $999 | $818,728 | 6 | Universal Pictures International (UPI) | false | false |
