| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 3 | Slumdog Millionaire | $300,659 | +5.3% | 44 | +8 | $6,833 | $3,798,725 | 11 | Pathé | false | false |
| 2 | 1 | Gran Torino | $277,514 | -13% | 50 | -2 | $5,550 | $1,574,178 | 4 | Warner Bros. | false | false |
| 3 | 2 | Marley & Me | $182,984 | -39.1% | 71 | -12 | $2,577 | $1,083,908 | 3 | 20th Century Fox International | false | false |
| 4 | - | Coco | $165,181 | - | 10 | - | $16,518 | $165,181 | 1 | JMH Distribution | true | false |
| 5 | 4 | The Reader | $163,928 | -22.2% | 30 | - | $5,464 | $797,840 | 5 | Ascot Elite Entertainment Group | false | false |
| 6 | - | Will You Marry Us? | $156,471 | - | 31 | - | $5,047 | $156,471 | 1 | Walt Disney Pictures | true | false |
| 7 | 5 | Confessions of a Shopaholic | $116,939 | -29.4% | 44 | - | $2,657 | $349,731 | 4 | Walt Disney Pictures | false | false |
| 8 | 7 | The Unborn | $67,853 | -41.5% | 24 | -1 | $2,827 | $191,020 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Watchmen | $64,610 | -55.2% | 25 | -28 | $2,584 | $529,332 | 3 | N/A | false | false |
| 10 | 8 | The Pink Panther 2 | $61,352 | -41.9% | 38 | +34 | $1,614 | $275,134 | 5 | Walt Disney Pictures | false | false |
| 11 | 10 | Yes Man | $60,392 | -23% | 23 | -1 | $2,625 | $1,273,276 | 11 | Warner Bros. | false | false |
| 12 | 9 | Milk | $58,707 | -29.8% | 29 | -3 | $2,024 | $705,801 | 9 | Ascot Elite Entertainment Group | false | false |
| 13 | - | Last Chance Harvey | $58,579 | - | 13 | - | $4,506 | $58,579 | 1 | Ascot Elite Entertainment Group | true | false |
| 14 | 18 | Mid-August Lunch | $52,444 | +23.1% | 13 | +7 | $4,034 | $175,326 | 16 | Xenix Filmdistribution | false | false |
| 15 | 15 | He's Just Not That Into You | $47,077 | -8.5% | 16 | -6 | $2,942 | $850,723 | 6 | Warner Bros. | false | false |
| 16 | 12 | Hotel for Dogs | $44,073 | -24.2% | 47 | -2 | $937 | $860,855 | 7 | Universal Pictures International (UPI) | false | false |
| 17 | 23 | The Tale of Despereaux | $40,676 | +892.3% | 38 | +26 | $1,070 | $128,463 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 11 | The Curious Case of Benjamin Button | $38,793 | -36.9% | 30 | -1 | $1,293 | $2,941,784 | 8 | Warner Bros. | false | false |
| 19 | 13 | Twilight | $37,800 | -35% | 18 | -14 | $2,100 | $2,886,373 | 18 | Ascot Elite Entertainment Group | false | false |
| 20 | 14 | The International | $34,534 | -34.3% | 14 | -2 | $2,466 | $666,415 | 6 | Walt Disney Pictures | false | false |
| 21 | 16 | Lilly the Witch: The Dragon and the Magic Book | $33,069 | -34.6% | 38 | -4 | $870 | $445,506 | 5 | Walt Disney Pictures | false | false |
| 22 | 19 | Revolutionary Road | $21,559 | -39.8% | 18 | -6 | $1,197 | $2,233,389 | 10 | Universal Pictures International (UPI) | false | false |
| 23 | - | Bolt | $10,385 | - | 14 | - | $741 | $1,782,764 | 17 | Walt Disney Pictures | false | false |
| 24 | 21 | Frost/Nixon | $3,641 | -37.6% | 4 | +1 | $910 | $177,851 | 6 | Universal Pictures International (UPI) | false | false |
| 25 | 25 | Fly Me to the Moon 3D | $3,031 | -5.4% | 1 | - | $3,031 | $124,329 | 21 | N/A | false | false |
| 26 | 24 | Role Models | $1,452 | -61.1% | 3 | -10 | $484 | $127,047 | 4 | Universal Pictures International (UPI) | false | false |
| 27 | 26 | Changeling | $1,233 | -50.6% | 2 | -6 | $616 | $1,458,301 | 19 | Universal Pictures International (UPI) | false | false |
| 28 | 22 | Friday the 13th | $1,025 | -81.4% | 3 | -5 | $341 | $313,766 | 6 | Universal Pictures International (UPI) | false | false |
| 29 | 27 | Madagascar: Escape 2 Africa | $54 | -97.5% | 1 | -3 | $54 | $11,010,683 | 16 | Universal Pictures International (UPI) | false | false |
