| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Watchmen | $1,482,474 | - | 344 | - | $4,309 | $1,482,474 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Confessions of a Shopaholic | $1,282,608 | -37.6% | 342 | -27 | $3,750 | $4,082,861 | 2 | Walt Disney Pictures | false | false |
| 3 | - | The Wrestler | $1,110,067 | - | 315 | - | $3,524 | $1,115,882 | 1 | Lucky Red | true | false |
| 4 | 2 | The Curious Case of Benjamin Button | $836,408 | -55.4% | 282 | -169 | $2,965 | $12,763,445 | 4 | Warner Bros. | false | false |
| 5 | - | Due partite | $723,633 | - | 210 | - | $3,445 | $723,633 | 1 | 01 Distribution | true | false |
| 6 | - | The Pink Panther 2 | $615,393 | - | 198 | - | $3,108 | $615,810 | 1 | Sony Pictures Releasing | true | false |
| 7 | 5 | Slumdog Millionaire | $594,150 | -31.1% | 160 | +1 | $3,713 | $6,292,823 | 14 | Lucky Red | false | false |
| 8 | 3 | Iago | $541,622 | -55.7% | 276 | -102 | $1,962 | $2,171,233 | 2 | Medusa Distribuzione | false | false |
| 9 | 4 | The Unborn | $498,250 | -49.3% | 173 | -6 | $2,880 | $1,856,778 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | The Reader | $382,890 | -42.9% | 134 | -27 | $2,857 | $2,324,936 | 3 | 01 Distribution | false | false |
| 11 | 6 | Ex | $345,516 | -57.2% | 133 | -103 | $2,597 | $13,088,609 | 5 | 01 Distribution | false | false |
| 12 | - | Eden Is West | $309,369 | - | 179 | - | $1,728 | $309,369 | 1 | Medusa Distribuzione | true | false |
| 13 | 7 | Inkheart | $285,105 | -64.4% | 159 | -90 | $1,793 | $2,840,564 | 3 | Eagle Pictures | false | false |
| 14 | - | Live! | $227,852 | - | 74 | - | $3,079 | $227,852 | 1 | Moviemax | true | false |
| 15 | 9 | Giulia Doesn't Date at Night | $184,551 | -57.6% | 104 | -75 | $1,774 | $786,451 | 2 | 01 Distribution | false | false |
| 16 | 14 | The Wave | $76,458 | -37.5% | 39 | -18 | $1,960 | $272,901 | 2 | BIM Distribuzione | false | false |
| 17 | 10 | Underworld: Rise of the Lycans | $75,028 | -80% | 64 | -55 | $1,172 | $1,437,633 | 3 | Sony Pictures Releasing | false | false |
| 18 | 16 | Journey to the Center of the Earth | $66,395 | -40.8% | 25 | -11 | $2,655 | $9,977,622 | 8 | 01 Distribution | false | false |
| 19 | 15 | Milk | $57,290 | -50.4% | 25 | -26 | $2,291 | $2,956,423 | 7 | BIM Distribuzione | false | false |
| 20 | 17 | Revolutionary Road | $42,151 | -53.1% | 19 | -27 | $2,218 | $4,459,952 | 6 | Universal Pictures International (UPI) | false | false |
| 21 | 13 | Impy's Wonderland | $41,638 | -72.2% | 91 | -52 | $457 | $219,190 | 2 | Mediafilm | false | false |
| 22 | 19 | Doubt | $28,041 | -52.4% | 19 | -14 | $1,475 | $2,272,157 | 6 | Walt Disney Pictures | false | false |
| 23 | 11 | Bride Wars | $27,403 | -92% | 31 | -192 | $883 | $1,645,824 | 3 | 20th Century Fox International | false | false |
| 24 | 18 | The Sicilian Girl | $22,738 | -71.8% | 19 | -34 | $1,196 | $135,950 | 2 | Istituto Luce | false | false |
| 25 | 29 | Márió, a varázsló | $16,401 | +23.9% | 4 | +1 | $4,100 | $168,913 | 15 | L'Altrofilm | false | false |
| 26 | 32 | Australia | $15,508 | +42.8% | 9 | +2 | $1,723 | $6,443,029 | 8 | 20th Century Fox International | false | false |
| 27 | 23 | I've Loved You So Long | $13,217 | -48.4% | 6 | -9 | $2,202 | $485,473 | 5 | Mikado Film | false | false |
| 28 | 27 | Beverly Hills Chihuahua | $10,687 | -43.4% | 20 | -6 | $534 | $4,869,502 | 8 | Walt Disney Pictures | false | false |
| 29 | 26 | Easy Virtue | $9,805 | -52.1% | 4 | -8 | $2,451 | $3,043,029 | 9 | Eagle Pictures | false | false |
| 30 | - | American Virgin | $9,425 | - | 1 | - | $9,425 | $15,696 | 457 | Eagle Pictures | false | false |
| 31 | 20 | Valkyrie | $8,381 | -75.7% | 8 | -23 | $1,047 | $5,718,252 | 6 | 01 Distribution | false | false |
| 32 | 31 | Empties | $8,317 | -27.4% | 5 | -1 | $1,663 | $374,689 | 8 | Fandango | false | false |
| 33 | 24 | Frost/Nixon | $8,245 | -64.1% | 6 | -4 | $1,374 | $811,381 | 5 | Universal Pictures International (UPI) | false | false |
| 34 | 40 | Katyn | $5,632 | +24% | 7 | +2 | $804 | $44,184 | 4 | N/A | false | false |
| 35 | 36 | The Visitor | $5,478 | -16% | 5 | +1 | $1,095 | $1,833,158 | 14 | Bolero Film | false | false |
| 36 | 38 | Lemon Tree | $5,198 | +0.3% | 5 | +2 | $1,039 | $1,320,100 | 13 | Teodora Film | false | false |
| 37 | 35 | The Boy in the Striped Pajamas | $4,526 | -51.5% | 8 | -6 | $565 | $3,369,830 | 12 | Walt Disney Pictures | false | false |
| 38 | 12 | Questo piccolo grande amore | $3,963 | -97.5% | 9 | -129 | $440 | $4,872,400 | 4 | Medusa Distribuzione | false | false |
| 39 | 42 | Mar nero | $2,943 | -28.1% | 2 | -2 | $1,471 | $97,240 | 6 | N/A | false | false |
| 40 | 37 | Waiting for the sun | $2,943 | -49.7% | 1 | -8 | $2,943 | $62,079 | 3 | Mikado Film | false | false |
| 41 | 34 | Space Chimps | $2,881 | -70.5% | 8 | -12 | $360 | $699,046 | 5 | Medusa Distribuzione | false | false |
| 42 | 33 | Religulous | $2,781 | -72.9% | 2 | -4 | $1,390 | $102,320 | 4 | Eagle Pictures | false | false |
| 43 | 21 | Friday the 13th | $2,779 | -91.2% | 6 | -29 | $463 | $1,575,502 | 4 | Universal Pictures International (UPI) | false | false |
| 44 | 44 | Giovanna's Father | $2,722 | -21.2% | 1 | - | $2,722 | $4,865,991 | 26 | Medusa Distribuzione | false | false |
| 45 | 22 | Italians | $2,389 | -92.2% | 3 | -19 | $796 | $17,018,911 | 7 | Filmauro | false | false |
| 46 | 39 | Appaloosa | $1,942 | -57.6% | 1 | -2 | $1,942 | $379,563 | 8 | 01 Distribution | false | false |
| 47 | 48 | Let the Right One In | $1,842 | -24.9% | 3 | +1 | $614 | $654,551 | 9 | Bolero Film | false | false |
| 48 | - | The Duchess | $1,772 | - | 2 | - | $886 | $2,895,499 | 11 | BIM Distribuzione | false | false |
| 49 | 25 | Hotel for Dogs | $1,403 | -93.1% | 8 | -31 | $175 | $88,248 | 3 | Universal Pictures International (UPI) | false | false |
| 50 | - | The Watcher | $1,214 | - | 1 | - | $1,214 | $3,037,400 | 443 | Medusa Distribuzione | false | false |
