| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Watchmen | $341,873 | - | 40 | - | $8,546 | $341,873 | 1 | United International Pictures | true | false |
| 2 | - | Marley & Me | $214,211 | - | 19 | - | $11,274 | $214,211 | 1 | N/A | true | false |
| 3 | - | What Just Happened | $84,534 | - | 14 | - | $6,038 | $84,534 | 1 | Gulf Film | true | false |
| 4 | 4 | Slumdog Millionaire | $74,614 | -20.4% | 11 | - | $6,783 | $1,155,929 | 7 | Gulf Film | false | false |
| 5 | 1 | The International | $70,626 | -69.8% | 11 | -8 | $6,420 | $368,334 | 2 | N/A | false | false |
| 6 | 6 | The Pink Panther 2 | $64,100 | -22.3% | 5 | -2 | $12,820 | $778,676 | 4 | N/A | false | false |
| 7 | 3 | The Curious Case of Benjamin Button | $54,764 | -57.2% | 7 | -8 | $7,823 | $585,199 | 3 | N/A | false | false |
| 8 | 2 | Day of the Dead | $45,924 | -65.4% | 17 | -3 | $2,701 | $211,787 | 2 | N/A | false | false |
| 9 | - | Crossing Over | $45,884 | - | 9 | - | $5,098 | $57,563 | 1 | N/A | true | false |
| 10 | 5 | Confessions of a Shopaholic | $35,578 | -58.4% | 5 | -10 | $7,115 | $340,482 | 3 | N/A | false | false |
| 11 | 8 | Garfield's Fun Fest | $25,379 | -12.3% | 8 | -9 | $3,172 | $114,845 | 3 | N/A | false | false |
| 12 | 14 | The Tale of Despereaux | $10,521 | +26.9% | 4 | +1 | $2,630 | $304,498 | 6 | N/A | false | false |
| 13 | 7 | Penelope | $9,393 | -77.4% | 6 | -8 | $1,565 | $60,333 | 2 | N/A | false | false |
| 14 | 13 | Yes Man | $8,521 | -9.9% | 1 | - | $8,521 | $733,349 | 7 | N/A | false | false |
| 15 | 9 | The Children of Huang Shi | $6,458 | -77% | 7 | -5 | $922 | $46,301 | 2 | N/A | false | false |
| 16 | 11 | Hasan Tayyarah | $5,979 | -71.1% | 6 | -4 | $996 | $33,551 | 2 | N/A | false | false |
| 17 | 17 | Madagascar: Escape 2 Africa | $2,870 | -7.3% | 1 | - | $2,870 | $1,902,645 | 15 | N/A | false | false |
| 18 | 16 | The Unborn | $2,788 | -25.3% | 2 | +1 | $1,394 | $509,011 | 5 | N/A | false | false |
| 19 | 22 | Twilight | $2,132 | +28.5% | 2 | +1 | $1,066 | $1,251,059 | 14 | N/A | false | false |
| 20 | 21 | My Mom's New Boyfriend | $2,099 | <0.1% | 2 | +1 | $1,049 | $158,189 | 6 | N/A | false | false |
| 21 | 18 | Role Models | $1,571 | -45.9% | 2 | +1 | $785 | $132,076 | 4 | N/A | false | false |
| 22 | 10 | The Tattooist | $839 | -96.6% | 2 | -14 | $419 | $189,218 | 3 | N/A | false | false |
