| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | He's Just Not That Into You | $1,003,208 | -37.2% | 252 | -1 | $3,980 | $7,036,392 | 3 | Roadshow Films | false | false |
| 2 | 4 | Slumdog Millionaire | $901,410 | +52.8% | 196 | +8 | $4,599 | $9,716,825 | 11 | Icon Film Distribution | false | false |
| 3 | 3 | Gran Torino | $610,326 | -10.7% | 205 | -2 | $2,977 | $7,814,769 | 6 | Roadshow Films | false | false |
| 4 | - | The Unborn | $546,488 | - | 125 | - | $4,371 | $546,488 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 2 | The International | $439,474 | -37.6% | 229 | - | $1,919 | $1,419,016 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | Last Chance Harvey | $386,566 | - | 140 | - | $2,761 | $412,542 | 1 | Icon Film Distribution | true | false |
| 7 | 7 | The Reader | $330,949 | -5.1% | 53 | - | $6,244 | $933,570 | 2 | Roadshow Films | false | false |
| 8 | 5 | Ghost Town | $301,666 | -38.3% | 198 | -2 | $1,523 | $2,098,690 | 3 | Paramount Pictures International | false | false |
| 9 | 6 | Zack and Miri Make a Porno | $259,397 | -45.7% | 130 | - | $1,995 | $950,830 | 2 | Roadshow Films | false | false |
| 10 | 8 | Changeling | $172,620 | -33% | 127 | -5 | $1,359 | $2,071,339 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Transporter 3 | $127,151 | -47.3% | 147 | -40 | $864 | $1,990,531 | 4 | Icon Film Distribution | false | false |
| 12 | - | The Combination | $120,063 | - | 32 | - | $3,751 | $120,063 | 1 | - | true | false |
| 13 | 13 | Twilight | $114,179 | -8.3% | 88 | -8 | $1,297 | $13,496,254 | 13 | - | false | false |
| 14 | 12 | Hotel for Dogs | $103,459 | -17.2% | 156 | +2 | $663 | $3,778,978 | 7 | Paramount Pictures International | false | false |
| 15 | 14 | Australia | $101,819 | -18.1% | 113 | -31 | $901 | $23,588,856 | 14 | 20th Century Fox International | false | false |
| 16 | 10 | My Bloody Valentine | $92,765 | -53.7% | 74 | -60 | $1,253 | $1,008,189 | 3 | Hoyts Distribution | false | false |
| 17 | 19 | Milk | $79,312 | +27.5% | 45 | +3 | $1,762 | $965,492 | 5 | Universal Pictures International (UPI) | false | false |
| 18 | 11 | Bride Wars | $76,096 | -44.1% | 104 | -35 | $731 | $7,234,050 | 7 | 20th Century Fox International | false | false |
| 19 | 15 | Underworld: Rise of the Lycans | $64,144 | -33.2% | 77 | -15 | $833 | $3,044,364 | 6 | Sony Pictures Releasing | false | false |
| 20 | - | W. | $59,939 | - | 52 | - | $1,152 | $85,540 | 1 | Hoyts Distribution | true | false |
| 21 | 21 | Marley & Me | $50,780 | +1.5% | 49 | -24 | $1,036 | $6,368,695 | 9 | 20th Century Fox International | false | false |
| 22 | 20 | The Curious Case of Benjamin Button | $48,213 | -15.4% | 77 | -11 | $626 | $10,479,423 | 10 | Warner Bros. | false | false |
| 23 | 16 | Valkyrie | $47,447 | -47.9% | 75 | -45 | $632 | $3,941,327 | 6 | 20th Century Fox International | false | false |
| 24 | 18 | Rachel Getting Married | $44,235 | -40.1% | 43 | - | $1,028 | $371,808 | 3 | Sony Pictures Releasing | false | false |
| 25 | 17 | Role Models | $43,296 | -50% | 68 | -21 | $636 | $4,277,884 | 7 | Universal Pictures International (UPI) | false | false |
| 26 | 22 | The Wrestler | $39,065 | -20.1% | 67 | +2 | $583 | $1,081,646 | 7 | Hopscotch Films | false | false |
| 27 | 27 | Vicky Cristina Barcelona | $25,779 | +29.1% | 44 | -4 | $585 | $2,086,931 | 10 | Hopscotch Films | false | false |
| 28 | 23 | Revolutionary Road | $25,581 | -34.1% | 47 | -15 | $544 | $1,946,669 | 6 | Paramount Pictures International | false | false |
| 29 | 24 | I've Loved You So Long | $25,472 | -32.4% | 35 | -7 | $727 | $1,234,130 | 10 | Palace Films | false | false |
| 30 | - | Delhi-6 | $22,362 | - | 10 | - | $2,236 | $22,362 | 1 | MG Distribution | true | false |
| 31 | 28 | Wild Ocean | $16,575 | -10.8% | 2 | - | $8,287 | $1,063,803 | 37 | IMAX | false | false |
| 32 | 29 | Madagascar: Escape 2 Africa | $9,922 | -20.2% | 18 | -7 | $551 | $15,078,122 | 12 | Paramount Pictures International | false | false |
| 33 | 30 | The Tale of Despereaux | $9,478 | -19.3% | 23 | -4 | $412 | $1,549,273 | 8 | Universal Pictures International (UPI) | false | false |
| 34 | - | Nick and Norah's Infinite Playlist | $8,998 | - | 3 | - | $2,999 | $8,998 | 1 | Sony Pictures Releasing | true | false |
| 35 | 31 | Frost/Nixon | $7,382 | -37% | 25 | -3 | $295 | $1,317,686 | 10 | Universal Pictures International (UPI) | false | false |
| 36 | 35 | Frozen River | $7,110 | +7.9% | 3 | - | $2,370 | $16,573 | 2 | Sony Pictures Releasing | false | false |
| 37 | 26 | Yes Man | $6,801 | -68.4% | 21 | -32 | $323 | $8,792,793 | 9 | Roadshow Films | false | false |
| 38 | 36 | The Dark Knight | $6,473 | +25.8% | 5 | - | $1,294 | $39,880,001 | 33 | Warner Bros. | false | false |
| 39 | 32 | The Class | $6,379 | -41.4% | 8 | -3 | $797 | $228,583 | 6 | Sony Pictures Releasing | false | false |
| 40 | 25 | Billu | $5,049 | -78.2% | 12 | -3 | $420 | $118,438 | 3 | Eros Worldwide | false | false |
| 41 | 40 | Dinosaurs: Giants of Patagonia | $3,667 | +15.5% | 2 | - | $1,833 | $2,069,100 | 91 | IMAX | false | false |
| 42 | 38 | Fly Me to the Moon 3D | $3,642 | -7.8% | 2 | - | $1,821 | $444,525 | 24 | IMAX | false | false |
| 43 | 39 | Grand Canyon Adventure: River at Risk | $3,542 | -8.1% | 1 | - | $3,542 | $346,017 | 37 | IMAX | false | false |
| 44 | 41 | Haunted Castle | $2,510 | -14.5% | 2 | - | $1,255 | $3,799,801 | 389 | IMAX | false | false |
| 45 | 43 | African Adventure: Safari in the Okavango | $2,468 | +37.6% | 1 | - | $2,468 | $719,946 | 102 | IMAX | false | false |
| 46 | 42 | U2 3D | $2,443 | +35.3% | 1 | - | $2,443 | $990,192 | 47 | Roadshow Films | false | false |
| 47 | 46 | Shackleton's Antarctic Adventure | $2,297 | +71.3% | 1 | - | $2,297 | $4,022,410 | 383 | N/A | false | false |
| 48 | - | Antarctica | $2,240 | - | 1 | - | $2,240 | $3,946,783 | - | IMAX | - | false |
| 49 | 45 | The Day the Earth Stood Still | $1,512 | +7.2% | 6 | - | $252 | $5,289,077 | 10 | 20th Century Fox International | false | false |
| 50 | 48 | Bustin' Down the Door | $1,399 | +34.9% | 4 | +3 | $349 | $69,837 | 7 | Madman Entertainment | false | false |
| 51 | 44 | Santa vs. the Snowman 3D | $1,115 | -30% | 1 | - | $1,115 | $1,659,400 | 328 | IMAX | false | false |
| 52 | 49 | The Spirit | $943 | -7.9% | 5 | +1 | $188 | $386,501 | 5 | Hoyts Distribution | false | false |
| 53 | - | Flash of Genius | $942 | - | 10 | - | $94 | $942 | 1 | Roadshow Films | true | false |
| 54 | 53 | Bugs! | $829 | +27.7% | 2 | +1 | $414 | $1,707,399 | 308 | N/A | false | false |
| 55 | - | Mysteries of Egypt | $683 | - | 1 | - | $683 | $4,104,100 | - | IMAX | - | false |
| 56 | 56 | The Human Body Undated Australia Release | $549 | +289.4% | 1 | - | $549 | $991,000 | 27 | IMAX | false | false |
| 57 | 47 | In Bruges | $488 | -56% | 2 | - | $244 | $2,518,493 | 27 | Icon Film Distribution | false | false |
| 58 | - | Under the Sea 3D | $303 | - | 1 | - | $303 | $303 | 1 | IMAX | true | false |
