| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The International | $234,154 | - | 19 | - | $12,323 | $234,154 | 1 | N/A | true | false |
| 2 | - | Day of the Dead | $132,589 | - | 20 | - | $6,629 | $132,589 | 1 | N/A | true | false |
| 3 | 1 | The Curious Case of Benjamin Button | $127,851 | -54.5% | 15 | -9 | $8,523 | $496,940 | 2 | N/A | false | false |
| 4 | 6 | Slumdog Millionaire | $93,685 | +86.7% | 11 | -3 | $8,516 | $1,053,969 | 6 | Gulf Film | false | false |
| 5 | 3 | Confessions of a Shopaholic | $85,576 | -39.4% | 15 | -1 | $5,705 | $278,970 | 2 | N/A | false | false |
| 6 | 2 | The Pink Panther 2 | $82,512 | -42.7% | 7 | -10 | $11,787 | $697,365 | 3 | N/A | false | false |
| 7 | - | Penelope | $41,551 | - | 14 | - | $2,967 | $41,551 | 1 | N/A | true | false |
| 8 | 7 | Garfield's Fun Fest | $28,944 | -36.2% | 17 | +1 | $1,702 | $86,602 | 2 | N/A | false | false |
| 9 | - | The Children of Huang Shi | $28,080 | - | 12 | - | $2,340 | $28,080 | 1 | N/A | true | false |
| 10 | 4 | The Tattooist | $24,344 | -80.6% | 16 | - | $1,521 | $180,442 | 2 | N/A | false | false |
| 11 | - | Hasan Tayyarah | $20,660 | - | 10 | - | $2,066 | $20,660 | 1 | N/A | true | false |
| 12 | - | Frost/Nixon | $18,616 | - | 11 | - | $1,692 | $18,616 | 1 | N/A | true | false |
| 13 | 10 | Yes Man | $9,457 | -38.7% | 1 | -1 | $9,457 | $721,826 | 6 | N/A | false | false |
| 14 | 13 | The Tale of Despereaux | $8,294 | -41.7% | 3 | -3 | $2,764 | $293,144 | 5 | N/A | false | false |
| 15 | 5 | Quarantine | $6,526 | -90.2% | 3 | -16 | $2,175 | $93,992 | 2 | N/A | false | false |
| 16 | 8 | The Unborn | $3,733 | -83.5% | 1 | -8 | $3,733 | $505,162 | 4 | N/A | false | false |
| 17 | 15 | Madagascar: Escape 2 Africa | $3,097 | -26.1% | 1 | - | $3,097 | $1,898,661 | 14 | N/A | false | false |
| 18 | 9 | Role Models | $2,905 | -84.4% | 1 | -6 | $2,905 | $129,733 | 3 | N/A | false | false |
| 19 | 18 | How to Lose Friends & Alienate People | $2,320 | +75.9% | 1 | - | $2,320 | $81,784 | 4 | N/A | false | false |
| 20 | 14 | Appaloosa | $2,209 | -63.8% | 1 | -4 | $2,209 | $86,721 | 3 | N/A | false | false |
| 21 | 17 | My Mom's New Boyfriend | $2,100 | +51.5% | 1 | - | $2,100 | $155,468 | 5 | N/A | false | false |
| 22 | 16 | Twilight | $1,659 | +13.9% | 1 | - | $1,659 | $1,248,449 | 13 | N/A | false | false |
| 23 | 11 | Solstice | $308 | -98% | 1 | -10 | $308 | $144,236 | 3 | N/A | false | false |
