| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | He's Just Not That Into You | $177,134 | - | 50 | - | $3,542 | $177,134 | 1 | NuMetro Distribution | true | false |
| 2 | - | Seven Pounds | $81,974 | - | 50 | - | $1,639 | $81,974 | 1 | Ster-Kinekor Pictures | true | false |
| 3 | 1 | Bedtime Stories | $76,728 | -14.9% | 51 | -4 | $1,504 | $321,886 | 3 | Ster-Kinekor Pictures | false | false |
| 4 | 2 | Bride Wars | $69,959 | -13.1% | 60 | - | $1,165 | $567,790 | 4 | NuMetro Distribution | false | false |
| 5 | 5 | Transporter 3 | $49,085 | -8.6% | 65 | -4 | $755 | $635,325 | 5 | United International Pictures | false | false |
| 6 | 4 | Role Models | $46,443 | -13.6% | 44 | - | $1,055 | $119,858 | 2 | United International Pictures | false | false |
| 7 | 3 | Valkyrie | $41,365 | -35.3% | 50 | +1 | $827 | $263,184 | 3 | NuMetro Distribution | false | false |
| 8 | 6 | The Secret Life of Bees | $29,569 | -19.6% | 24 | -1 | $1,232 | $80,174 | 2 | NuMetro Distribution | false | false |
| 9 | 7 | Yes Man | $26,292 | -13.3% | 41 | -13 | $641 | $858,623 | 7 | NuMetro Distribution | false | false |
| 10 | - | Billu | $22,146 | - | 5 | - | $4,429 | $22,146 | 1 | NuMetro Distribution | true | false |
| 11 | 11 | Mr. Bones 2: Back from the Past | $19,250 | -1.8% | 28 | -12 | $687 | $3,601,403 | 12 | United International Pictures | false | false |
| 12 | 13 | My Bloody Valentine | $18,612 | +4.6% | 9 | - | $2,068 | $47,860 | 2 | NuMetro Distribution | false | false |
| 13 | 9 | Twilight | $17,044 | -18.9% | 30 | -8 | $568 | $801,542 | 9 | NuMetro Distribution | false | false |
| 14 | 14 | Doubt | $15,461 | -12.6% | 11 | +1 | $1,405 | $41,415 | 2 | Ster-Kinekor Pictures | false | false |
| 15 | 8 | The Duchess | $14,964 | -30% | 12 | - | $1,247 | $84,762 | 3 | Ster-Kinekor Pictures | false | false |
| 16 | 10 | Revolutionary Road | $14,259 | -31.5% | 18 | - | $792 | $153,171 | 4 | United International Pictures | false | false |
| 17 | 15 | Burn After Reading | $9,885 | -39.9% | 15 | -7 | $659 | $283,793 | 6 | Ster-Kinekor Pictures | false | false |
| 18 | 22 | Bolt | $8,886 | +49.2% | 20 | +1 | $444 | $927,802 | 8 | Ster-Kinekor Pictures | false | false |
| 19 | 19 | Saw V | $6,758 | -6.9% | 17 | -2 | $397 | $124,351 | 5 | Ster-Kinekor Pictures | false | false |
| 20 | 17 | Happy-Go-Lucky | $6,463 | -29.9% | 10 | - | $646 | $19,655 | 2 | United International Pictures | false | false |
| 21 | 25 | Killshot | $6,363 | +106.3% | 14 | +1 | $454 | $85,042 | 4 | Ster-Kinekor Pictures | false | false |
| 22 | 12 | Four Christmases | $6,115 | -66.8% | 30 | -7 | $203 | $489,210 | 6 | NuMetro Distribution | false | false |
| 23 | 20 | Vicky Cristina Barcelona | $4,962 | -29.4% | 7 | -3 | $708 | $170,295 | 7 | United International Pictures | false | false |
| 24 | 21 | Madagascar: Escape 2 Africa | $4,677 | -32% | 10 | -5 | $467 | $2,089,640 | 11 | United International Pictures | false | false |
| 25 | 18 | Frost/Nixon | $4,136 | -50.2% | 8 | -2 | $517 | $30,214 | 3 | United International Pictures | false | false |
| 26 | - | The World Unseen | $3,168 | - | 6 | - | $528 | $4,903 | 1 | Ster-Kinekor Pictures | true | false |
| 27 | - | Appaloosa | $1,219 | - | 5 | - | $243 | $1,219 | 1 | NuMetro Distribution | true | false |
