| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Friday the 13th | $54,814 | - | 7 | - | $7,830 | $62,094 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | The Curious Case of Benjamin Button | $42,026 | -20.1% | 6 | - | $7,004 | $113,845 | 2 | Garsu Pasaulio Irasai | false | false |
| 3 | 2 | Beverly Hills Chihuahua | $27,659 | -33.1% | 7 | - | $3,951 | $103,099 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 4 | Yes Man | $20,544 | +7.2% | 7 | - | $2,934 | $442,935 | 6 | Garsu Pasaulio Irasai | false | false |
| 5 | 3 | The Return of the Musketeers, or The Treasures of Cardinal Mazarin | $20,405 | -31.7% | 6 | - | $3,400 | $62,548 | 2 | ACME | false | false |
| 6 | - | He's Just Not That Into You | $19,139 | - | - | - | - | $19,139 | - | - | - | false |
| 7 | - | Slumdog Millionaire | $15,490 | - | 2 | - | $7,745 | $22,355 | 1 | ACME | true | false |
| 8 | 5 | Fly Me to the Moon 3D | $9,565 | -36.8% | 1 | - | $9,565 | $105,296 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Revolutionary Road | $7,004 | -34% | 4 | - | $1,751 | $46,364 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Changeling | $5,255 | -33.4% | 4 | - | $1,313 | $65,792 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 6 | Underworld: Rise of the Lycans | $4,574 | -67.7% | 6 | -1 | $762 | $73,893 | 3 | ACME | false | false |
| 12 | 10 | The Tale of Despereaux | $4,414 | +3.6% | 5 | -1 | $882 | $251,922 | 8 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | U2 3D | $3,183 | -29.9% | 1 | - | $3,183 | $50,580 | 4 | Universal Pictures International (UPI) | false | false |
| 14 | 16 | The Boy in the Striped Pajamas | $1,303 | +14.4% | 3 | - | $434 | $71,333 | 7 | Universal Pictures International (UPI) | false | false |
| 15 | 19 | Twilight | $1,126 | +163.1% | 1 | - | $1,126 | $101,859 | 11 | ACME | false | false |
| 16 | 12 | Bride Wars | $1,072 | -65.7% | 1 | -5 | $1,072 | $140,553 | 5 | Universal Pictures International (UPI) | false | false |
| 17 | - | Frost/Nixon | $906 | - | 1 | - | $906 | $1,118 | 1 | Universal Pictures International (UPI) | true | false |
| 18 | - | The Art of Negative Thinking | $893 | - | 1 | - | $893 | $4,792 | 3 | N/A | false | false |
| 19 | 14 | Madagascar: Escape 2 Africa | $772 | -53% | 2 | -1 | $386 | $686,565 | 12 | Universal Pictures International (UPI) | false | false |
| 20 | 11 | Samyy luchshiy film 2 | $749 | -80.1% | 2 | -1 | $374 | $94,439 | 4 | ACME | false | false |
